Research Summary

Research Summary imageCurrent areas of special interest include:

  • Studies of virulence gene regulation in bacterial pathogens such as  Listeria monocytogenes, Corynebacterium dyphteriae and Enterococcus faecalis,
  • Research on secreted bacterial virulence factors of Chlamydia spp.,
  • Biofilm research including host-pathogen studies of Staphylococcus aureus, Acinetobacter baumannii, Klebsiella pneumoniae, Clostridium difficile, and Mycobacterium tuberculosis biofilms for vaccine development and improved diagnostics, and
  • Research on lipopolysaccharide structure and modification in Pseudomonas aeruginosa and others potential agents of biowarfare and emerging diseases.

Other developing interests are:

  • Early childhood caries, opportunistic infections affecting immuno-deficient patients
  • cancrum oris (noma)
  • Endodontic/systemic infections

Approaches include genomic and post-genomic collaborative projects with scientists of the Institute for Genome Science, molecular and cell biology studies, biomathematical and animal modeling approaches and the state-of-the-art imaging methodologies.