Dr. Hanping Feng Lab
Clostridium difficile infection (CDI) is becoming a major public health problem. The research in Dr. Feng’s lab is primarily focusing on the investigation of pathogenesis of CDI and host defense mechanisms, as well as the development of immune-based interventions against the infection. The laboratory utilizes techniques in the areas of microbiology and immunology, as well as molecular and cellular biology, to study the interaction of C. difficile toxins with intestinal epithelial and immune cells. The laboratory is also developing novel chimeric vaccines and unique toxin-binding agents, such as VHHs and aptamers, in order to prevent and treat the disease. Several animal models of CDI have been established in the laboratory.