Peer-Reviewed Publications

  • Mehta KK, Paskaleva EE, Wu X, Grover N, Mundra RV, Chen K, Zhang Y, Yang Z, Feng H, Dordick JS, Kane RS. Newly identified bacteriolytic enzymes that target a wide range of clinical isolates of Clostridium difficile. Biotechnol and bioeng. 2016; 113(12):2568-2576. PubMed PMID: 27260850 PMCID: PMC5367918
  • Yang Z, Shi L, Yu H, Zhang Y, Chen K, Saint Fleur A, Bai G, Feng H. Intravenous adenovirus expressing a multi-specific, single-domain antibody neutralizing TcdA and TcdB protects mice from Clostridium difficile infection. Pathog Dis. 2016; 74(7). PubMed PMID: 27502696 
  • Chen S, Wang H, Gu H, Sun C, Li S, Feng H, Wang J. Identification of an Essential Region for Translocation of Clostridium difficile Toxin B. Toxins. 2016; 8(8). PubMed PMID: 27537911, PMCID: PMC4999857 
  • Zhang Y, Feng H. Pathogenic effects of glucosyltransferase from Clostridium difficile toxins. Pathog Dis. 2016; 74(4):ftw024. PubMed PMID: 27044305 
  • Hamza T, Zhang Z, Melnyk RA, Feng H. Defective mutations within the translocation domain of Clostridium difficile toxin B impair disease pathogenesis. Pathog Dis. 2016; 74(1):ftv098. PubMed PMID: 26507679, PMCID: PMC4882082 
  • Maldarelli GA, Matz H, Gao S, Chen K, Hamza T, Yfantis HG, Feng H, Donnenberg MS. Pilin Vaccination Stimulates Weak Antibody Responses and Provides No Protection in a C57BL/6 Murine Model of Acute Clostridium difficile Infection. J Vaccines Vaccin. 2016; 7(3). NIHMSID: NIHMS796148 PubMed PMID: 27375958, PMCID: PMC4927082 
  • Yang Z, Zhang Y, Huang T, Feng H. Glucosyltransferase activity of Clostridium difficile Toxin B is essential for disease pathogenesis. Gut microbes. 2015; 6(4):221-4. PubMed PMID: 26091306, PMCID: PMC4615278 
  • Yu H, Chen K, Wu J, Yang Z, Shi L, Barlow LL, Aronoff DM, Garey KW, Savidge TC, von Rosenvinge EC, Kelly CP, Feng H. Identification of toxemia in patients with Clostridium difficile infection. PloS one. 2015; 10(4):e0124235. PubMed PMID: 25885671, PMCID: PMC4401762 
  • Zhang Y, Hamza T, Gao S, Feng H. Masking autoprocessing of Clostridium difficile toxin A by the C-terminus combined repetitive oligo peptides. Biochem Biophys Res Commun. 2015; 459(2):259-63. NIHMSID: NIHMS670964 PubMed PMID: 25725153, PMCID: PMC4426850 
  • Huang T, Perez-Cordon G, Shi L, Li G, Sun X, Wang X, Wang J, Feng H. Clostridium difficile toxin B intoxicated mouse colonic epithelial CT26 cells stimulate the activation of dendritic cells. Pathog Dis. 2015; 73(3). NIHMSID: NIHMS689777 PubMed PMID: 25743476, PMCID: PMC4435672 
  • Yuan P, Zhang H, Cai C, Zhu S, Zhou Y, Yang X, He R, Li C, Guo S, Li S, Huang T, Perez-Cordon G, Feng H, Wei W. Chondroitin sulfate proteoglycan 4 functions as the cellular receptor for Clostridium difficile toxin B. Cell Res. 2015; 25(2):157-68. PubMed PMID: 25547119, PMCID: PMC4650570 
  • Yang Z, Ramsey J, Hamza T, Zhang Y, Li S, Yfantis HG, Lee D, Hernandez LD, Seghezzi W, Furneisen JM, Davis NM, Therien AG, Feng H. Mechanisms of protection against Clostridium difficile infection by the monoclonal antitoxin antibodies actoxumab and bezlotoxumab. Infect Immun. 2015; 83(2):822-31. PubMed PMID: 25486992, PMCID: PMC4294251 
  • Zhu Z, Shi L, Feng H, Zhou HS. Single domain antibody coated gold nanoparticles as enhancer for Clostridium difficile toxin detection by electrochemical impedance immunosensors. Bioelectrochemistry (Amsterdam, Netherlands). 2015; 101:153-8. NIHMSID: NIHMS747270 PubMed PMID: 25460611, PMCID: PMC4706752 
  • Li S, Shi L, Yang Z, Zhang Y, Perez-Cordon G, Huang T, Ramsey J, Oezguen N, Savidge TC, Feng H. Critical roles of Clostridium difficile toxin B enzymatic activities in pathogenesis. Infect Immun. 2015; 83(2):502-13. PubMed PMID: 25404023, PMCID: PMC4294253  
  • Huang T, Li S, Li G, Tian Y, Wang H, Shi L, Perez-Cordon G, Mao L, Wang X, Wang J, Feng H. Utility of Clostridium difficile toxin B for inducing anti-tumor immunity. PloS one. 2014; 9(10):e110826. PubMed PMID: 25340750, PMCID: PMC4207755  
  • Yang Z, Schmidt D, Liu W, Li S, Shi L, Sheng J, Chen K, Yu H, Tremblay JM, Chen X, Piepenbrink KH, Sundberg EJ, Kelly CP, Bai G, Shoemaker CB, Feng H. A novel multivalent, single-domain antibody targeting TcdA and TcdB prevents fulminant Clostridium difficile infection in mice. J Infect Dis. 2014; 210(6):964-72. PubMed PMID: 24683195, PMCID: PMC4192054 
  • Perez-Cordon G, Yang G, Zhou B, Nie W, Li S, Shi L, Tzipori S, Feng H. Interaction of Cryptosporidium parvum with mouse dendritic cells leads to their activation and parasite transportation to mesenteric lymph nodes. Pathog Dis. 2014; 70(1):17-27. NIHMSID: NIHMS515605 PubMed PMID: 23913680, PMCID: PMC4426866 
  • Li S, Shi L, Yang Z, Feng H. Cytotoxicity of Clostridium difficile toxin B does not require cysteine protease-mediated autocleavage and release of the glucosyltransferase domain into the host cell cytosol. Pathog Dis. 2013; 67(1):11-8. NIHMSID: NIHMS428011 PubMed PMID: 23620115, PMCID: PMC3742912 
  • Zhang Y, Shi L, Li S, Yang Z, Standley C, Yang Z, ZhuGe R, Savidge T, Wang X, Feng H. A segment of 97 amino acids within the translocation domain of Clostridium difficile toxin B is essential for toxicity. PloS one. 2013; 8(3):e58634. PubMed PMID: 23484044, PMCID: PMC3590123 
  • Butler MM, Shinabarger DL, Citron DM, Kelly CP, Dvoskin S, Wright GE, Feng H, Tzipori S, Bowlin TL. MBX-500, a hybrid antibiotic with in vitro and in vivo efficacy against toxigenic Clostridium difficile. Antimicrob Agents Chemother. 2012; 56(9):4786-92. PubMed PMID: 22733075, PMCID: PMC3421853 
  • Wang H, Sun X, Zhang Y, Li S, Chen K, Shi L, Nie W, Kumar R, Tzipori S, Wang J, Savidge T, Feng H. A chimeric toxin vaccine protects against primary and recurrent Clostridium difficile infection. Infect Immun. 2012; 80(8):2678-88. PubMed PMID: 22615245, PMCID: PMC3434558 
  • Steele J, Chen K, Sun X, Zhang Y, Wang H, Tzipori S, Feng H. Systemic dissemination of Clostridium difficile toxins A and B is associated with severe, fatal disease in animal models. J Infect Dis. 2012; 205(3):384-91. PubMed PMID: 22147798, PMCID: PMC3256947 
  • Oezguen N, Power TD, Urvil P, Feng H, Pothoulakis C, Stamler JS, Braun W, Savidge TC. Clostridial toxins: sensing a target in a hostile gut environment. Gut microbes. 2012; 3(1):35-41. PubMed PMID: 22356854, PMCID: PMC3337123 
  • Krautz-Peterson G, Zhang Y, Chen K, Oyler GA, Feng H, Shoemaker CB. Retargeting Clostridium difficile Toxin B to Neuronal Cells as a Potential Vehicle for Cytosolic Delivery of Therapeutic Biomolecules to Treat Botulism. J Toxicol. 2012; 2012:760142. PubMed PMID: 21941543, PMCID: PMC3177232 
  • Savidge TC, Urvil P, Oezguen N, Ali K, Choudhury A, Acharya V, Pinchuk I, Torres AG, English RD, Wiktorowicz JE, Loeffelholz M, Kumar R, Shi L, Nie W, Braun W, Herman B, Hausladen A, Feng H, Stamler JS, Pothoulakis C. Host S-nitrosylation  inhibits clostridial small molecule-activated glucosylating toxins. Nat Med. 2011; 17(9):1136-41. NIHMSID: NIHMS352641 PubMed PMID:21857653, PMCID: PMC3277400 
  • Sun X, Wang H, Zhang Y, Chen K, Davis B, Feng H. Mouse relapse model of Clostridium difficile infection. Infect Immun. 2011; 79(7):2856-64. PubMed PMID: 21576341, PMCID: PMC3191975 
  • Cheng Y, Du P, Chen C, Yan S, Jia H, Wang J, Yan Q, Feng H, Lu J. Toxin A-negative, toxin B-positive Clostridium difficile infection diagnosed by polymerase chain reaction. Infect Control Hosp Epidemiol. 2011; 32(5):520-2. PubMed PMID: 21515990 
  • Zhang Q, Feng X, Nie W, Golenbock DT, Mayanja-Kizza H, Tzipori S, Feng H. MyD88-dependent pathway is essential for the innate immunity to Enterocytozoon bieneusi. Parasite Immunol. 2011; 33(4):217-25. NIHMSID: NIHMS253610 PubMed PMID: 21204848, PMCID: PMC3075804 
  • Gerhard R, Queisser S, Tatge H, Meyer G, Dittrich-Breiholz O, Kracht M, Feng H, Just I. Down-regulation of interleukin-16 in human mast cells HMC-1 by Clostridium difficile toxins A and B. Naunyn Schmiedebergs Arch Pharmacol. 2011; 383(3):285-95. PubMed PMID: 21267712 
  • Perez-Cordon G, Nie W, Schmidt D, Tzipori S, Feng H. Involvement of host calpain in the invasion of Cryptosporidium parvum. Microbes Infect. 2011; 13(1):103-7. NIHMSID: NIHMS253683 PubMed PMID: 21087681, PMCID: PMC3014416 
  • Ng J, Hirota SA, Gross O, Li Y, Ulke-Lemee A, Potentier MS, Schenck LP, Vilaysane A, Seamone ME, Feng H, Armstrong GD, Tschopp J, Macdonald JA, Muruve DA, Beck PL. Clostridium difficile toxin-induced inflammation and intestinal injury are mediated by the inflammasome. Gastroenterology. 2010; 139(2):542-52, 552.e1-3. PubMed PMID: 20398664 
  • Sun X, Savidge T, Feng H. The enterotoxicity of Clostridium difficile toxins. Toxins. 2010; 2(7):1848-80. PubMed PMID: 22069662, PMCID: PMC3153265 
  • Steele J, Feng H, Parry N, Tzipori S. Piglet models of acute or chronic Clostridium difficile illness. J Infect Dis. 2010; 201(3):428-34. NIHMSID: NIHMS163175 PubMed PMID: 20039803, PMCID: PMC2804769 
  • He X, Wang J, Steele J, Sun X, Nie W, Tzipori S, Feng H. An ultrasensitive rapid immunocytotoxicity assay for detecting Clostridium difficile toxins. J Microbiol Methods. 2009; 78(1):97-100. NIHMSID: NIHMS126645 PubMed PMID: 19393695, PMCID: PMC2740367 
  • Sun X, He X, Tzipori S, Gerhard R, Feng H. Essential role of the glucosyltransferase activity in Clostridium difficile toxin-induced secretion of TNF-alpha by macrophages. Microb Pathog. 2009; 46(6):298-305. NIHMSID: NIHMS104821 PubMed PMID: 19324080, PMCID: PMC2692465 
  • He X, Sun X, Wang J, Wang X, Zhang Q, Tzipori S, Feng H. Antibody-enhanced, Fc gamma receptor-mediated endocytosis of Clostridium difficile toxin A. Infect Immun. 2009; 77(6):2294-303. PubMed PMID: 19307220, PMCID: PMC2687358 
  • Yang G, Zhou B, Wang J, He X, Sun X, Nie W, Tzipori S, Feng H. Expression of recombinant Clostridium difficile toxin A and B in Bacillus megaterium. BMC Microbiol. 2008; 8:192. PubMed PMID: 18990232, PMCID: PMC2586027 
  • Krautz-Peterson G, Chapman-Bonofiglio S, Boisvert K, Feng H, Herman IM, Tzipori S, Sheoran AS. Intracellular neutralization of shiga toxin 2 by an a subunit-specific human monoclonal antibody. Infect Immun.  2008; 76(5):1931-9. PubMed PMID: 18285498, PMCID: PMC2346683 
  • Feng H, Nie W, Bonilla R, Widmer G, Sheoran A, Tzipori S. Quantitative tracking of Cryptosporidium infection in cell culture with CFSE. J Parasitol. 2006; 92(6):1350-4. PubMed PMID: 17304819 
  • Feng H, Nie W, Sheoran A, Zhang Q, Tzipori S. Bile acids enhance invasiveness of Cryptosporidium spp. into cultured cells. Infect Immun. 2006; 74(6):3342-6. PubMed PMID: 16714562, PMCID: PMC1479245 
  • Feng H, Zhang D, Palliser D, Zhu P, Cai S, Schlesinger A, Maliszewski L, Lieberman J. Listeria-infected myeloid dendritic cells produce IFN-beta, priming T cell activation. J Immunol. (Baltimore, Md. : 1950). 2005; 175(1):421-32. PubMed PMID: 15972676 
  • Zhu P, Sang Y, Xu H, Zhao J, Xu R, Sun Y, Xu T, Wang X, Chen L, Feng H, Li C, Zhao S. ADAM22 plays an important role in cell adhesion and spreading with the assistance of 14-3-3. Biochem Biophys Res Commun. 2005; 331(4):938-46. PubMed PMID: 15882968 
  • Cai S, Dole VS, Bergmeier W, Scafidi J, Feng H, Wagner DD, Davis AE 3rd. A direct role for C1 inhibitor in regulation of leukocyte adhesion. J Immunol. (Baltimore, Md. : 1950). 2005; 174(10):6462-6. PubMed PMID: 15879149 
  • Shi L, Keefe D, Durand E, Feng H, Zhang D, Lieberman J. Granzyme B binds to target cells mostly by charge and must be added at the same time as perforin to trigger apoptosis. J Immunol. (Baltimore, Md. : 1950). 2005; 174(9):5456-61. PubMed PMID: 15843543 
  • Zeng Y, Graner MW, Feng H, Li G, Katsanis E. Imatinib mesylate effectively combines with chaperone-rich cell lysate-loaded dendritic cells to treat bcr-abl+ murine leukemia. Int J Cancer. 2004; 110(2):251-9. PubMed PMID: 15069690 
  • Feng H, Zeng Y, Graner MW, Whitesell L, Katsanis E. Evidence for a Novel, Caspase-8-Independent, Fas Death Domain-Mediated Apoptotic Pathway. J Biomed Biotechnol. 2004; 2004(1):41-51. PubMed PMID: 15123887, PMCID: PMC545657 
  • Zeng Y, Feng H, Graner MW, Katsanis E. Tumor-derived, chaperone-rich cell lysate activates dendritic cells and elicits potent antitumor immunity. Blood. 2003; 101(11):4485-91. PubMed PMID: 12576309 
  • Graner MW, Zeng Y, Feng H, Katsanis E. Tumor-derived chaperone-rich cell lysates are effective therapeutic vaccines against a variety of cancers. Cancer Immunol Immunother. : CII. 2003; 52(4):226-34. PubMed PMID: 12669247 
  • Feng H, Zeng Y, Graner MW, Likhacheva A, Katsanis E. Exogenous stress proteins enhance the immunogenicity of apoptotic tumor cells and stimulate antitumor immunity. Blood. 2003; 101(1):245-52. PubMed PMID: 12393411 
  • Feng H, Zeng Y, Graner MW, Katsanis E. Stressed apoptotic tumor cells stimulate dendritic cells and induce specific cytotoxic T cells. Blood. 2002; 100(12):4108-15. PubMed PMID: 12393401 
  • Feng H, Zeng Y, Whitesell L, Katsanis E. Stressed apoptotic tumor cells express heat shock proteins and elicit tumor-specific immunity. Blood. 2001; 97(11):3505-12. PubMed PMID: 11369644 
  • He L, Feng H, Raymond A, Kreeger M, Zeng Y, Graner M, Whitesell L, Katsanis E. Dendritic-cell-peptide immunization provides immunoprotection against bcr-abl-positive leukemia in mice. Cancer Immunol Immunother.: CII. 2001; 50(1):31-40. PubMed PMID: 11315508