Our laboratory is interested in understanding the fundamental biological principles that lead to Staphylococcus aureus infections, an important human bacterial pathogen that is responsible for causing high morbidity and mortality worldwide. During the course of the past 4-5 years, our research has identified several interesting and novel pathways that are involved in beta-lactam resistance in S. aureus. Beta-lactam drugs remain as one of the gold standards of treatment for bacterial infections due to their superior efficacy and safety over other drugs. Widespread resistance in bacteria however limits its use. Studying novel pathways will decipher their role/s in the beta-lactam resistance process. Moreover, our work will elucidate various unknown aspects of basic biology, such as bacterial cell signaling, gene regulation and protein-protein interactions, which are crucial for bacterial resistance.
We are always looking for motivated and collegial candidates for the lab. If you are interested in our research questions please contact firstname.lastname@example.org with your CV and a statement explaining why you would like to work in our group.
Current Research Foci:
- Decipher the biological basis for pathogenic of S. aureus using a wide variety of molecular biology, genomic, biochemical, and immunological approaches.
- Study beta-lactam drug resistant phenotypes and genotypes through proteomics and genomics.
- Explore non-canonical (novel) targets responsible for beta-lactam resistance in S. aureus to re-sensitize resistant bacteria to beta-lactam drugs.
- Explore novel approaches, such as developing nano-bodies, to treat staphylococcal infections.