Publications

2015

41. Colby JM, Krantz BA. (2015) "Peptide Probes Reveal a Hydrophobic Steric Ratchet in the Anthrax Toxin Protective Antigen Translocase." J Mol Biol. 427: 3598. [Abstract] [Journal]

40. Brown MJ, Thoren KL, Krantz BA. (2015) "Role of the α Clamp in the Protein Translocation Mechanism of Anthrax Toxin." J Mol Biol. 427: 3340. [Abstract] [Journal]

2013

39. Abrami L, Brandi L, Moayeri M, Brown MJ, Krantz BA, Leppla SH, van der Goot FG. (2013) "Hijacking multivesicular bodies enables long-term and exosome-mediated long-distance action of anthrax toxin." Cell Rep. 5: 986. [Abstract] [Journal]

2012

 38. Wynia Smith SL, Brown MJ, Chirichella G, Krantz BA. (2012) "Electrostatic Ratchet In The Protective Antigen Channel Promotes Anthrax Toxin Translocation." J. Biol. Chem. 287: 43753.[Abstract] [Journal]

 37. Kintzer AF, Tang II, Schawel AK, Brown MJ, Krantz BA. (2012) "Anthrax toxin protective antigen integrates poly-γ-d-glutamate and pH signals to sense the optimal environment for channel formation." Proc. Natl Acad. Sci. 109: 18378. [Abstract] [Journal]  [PDB-4EE2-Coords] [PDB-4EE2-Entry]

 36. von Moltke J, Trinidad NJ, Moayeri M, Kintzer AF, Wang SB, van Rooijen N, Brown CR, Krantz BA, Leppla SH, Gronert K, Vance RE. (2012) "Rapid induction of inflammatory lipid mediators by the inflammasome in vivo." Nature. 490: 107. [Abstract] [Journal]

 35. Feld GK, Brown MJ, Krantz BA. (2012) "Ratcheting up protein translocation with anthrax toxin." Protein Sci.   21: 606. [Abstract] [Journal]

 34. Feld GK, Kintzer AF, Tang II, Thoren KL, Krantz BA. (2012) "Domain flexibility modulates the heterogeneous assembly mechanism of anthrax protective antigen." J. Mol. Biol. 415: 159.[Abstract] [Journal]

 33. Sterling HJ, Kintzer AF, Feld GK, Cassou CA, Krantz BA, Williams ER. (2012) "Supercharging Protein Complexes from Aqueous Solution Disrupts their Native Conformations." J. Am. Soc. Mass Spectrom. 23: 191. [Abstract] [Journal]

 2011

 32. Sterling HJ, Cassou CA, Trnka MJ, Burlingame AL, Krantz BA, Williams ER. (2011) "The role of conformational flexibility on protein supercharging in native electrospray ionization." Phys. Chem. Chem. Phys. 13: 18288. [Abstract]  [Journal]

 31. Brown MJ, Thoren KL, Krantz BA. (2011) "Charge requirements for proton gradient-driven translocation of anthrax toxin." J Biol Chem. 286(26): 23189. [Abstract] [Journal]

 30. Thoren KL & Krantz BA. (2011) "The unfolding story of anthrax toxin translocation." Mol. Micro. 80: 588. [Abstract] [Journal]

 2010

 29. Feld GK, Thoren KL, Kintzer AF, Sterling HJ, Tang II, Greenberg SG, Williams ER, Krantz BA. (2010) "Structural basis for the unfolding of anthrax lethal factor by protective antigen oligomers." Nature Struct. Mol. Biol. 17: 1383. [Abstract] [Journal] [PDB-3KWV-Coords] [PDB-3KWV-Entry]

  • Spotlight: "The Tale of Anthrax Unfolds" by Eva J. Gordon ACS Chem. Biol. 5: 1093. [DOI]

 28. Kintzer AF, Sterling HJ, Tang II, Williams ER, Krantz BA. (2010) "Anthrax toxin receptor drives protective antigen oligomerization and stabilizes the heptameric and octameric oligomer by a similar mechanism." PLoS ONE 5: e13888. [Abstract] [Journal]

 27. Sterling HJ, Daly MP, Feld GK, Thoren KL, Kintzer AF, Krantz BA, Williams ER. (2010) "Effects of supercharging reagents on noncovalent complex structure in electrospray ionization from aqueous solutions." J. Am. Soc. Mass Spectrom. 21: 1762. [Abstract] [Journal]

 26. Kintzer AF, Sterling HJ, Tang II, Abdul-Gader A, Miles AJ, Wallace BA, Williams ER, Krantz BA. (2009) "Role of the protective antigen octamer in the molecular mechanism of anthrax lethal toxin stabilization in plasma." J. Mol. Biol. 399: 741. [Abstract] [Journal]

 2009

 25. Thoren KL, Worden EJ, Yassif JM, Krantz BA. (2009) "Lethal factor unfolding is the most force-dependent step of anthrax toxin translocation." Proc. Natl Acad. Sci. 106: 21555.[Abstract] [Journal]

 24. Kintzer AF, Thoren KL, Sterling HJ, Dong KC, Feld GK, Tang II, Zhang TT, Williams ER, Berger JM, Krantz BA. (2009) "The protective antigen component of anthrax toxin forms functional octameric complexes." J. Mol. Biol. 392: 614. [Abstract] [Journal] [PDB-3HVD-Coords] [PDB-3HVD-Entry]

 23. Krantz B. (2009) "Bryan Krantz: From folding to unfolding proteins. Interview by Liz Savage." J. Cell Biol. 184: 618. [Abstract] [Journal]

 2007

 22. Pandit AD, Krantz BA, Dothager RS, Sosnick TR. (2007) "Characterizing protein folding transition States using Ψ-analysis." Methods Mol. Biol. 350: 83. [Abstract] [Book chapter]

 2006

 21. Sosnick TR, Krantz BA, Dothager RS, Baxa M. (2006) "Characterizing the protein folding transition state using Ψ analysis." Chem. Rev. 106: 1862. [Abstract] [Journal]

 20. Christensen KA, Krantz BA, Collier RJ. (2006) "Assembly and disassembly kinetics of anthrax toxin complexes." Biochemistry. 45: 2380. [Abstract] [Journal]

 19. Krantz BA, Finkelstein A, Collier RJ. (2006) "Protein translocation through the anthrax toxin transmembrane pore is driven by a proton gradient." J. Mol. Biol. 355: 968. [Abstract] [Journal]

 2005

 18. Wolfe JT, Krantz BA, Rainey GJA, Young JAT, Collier RJ. (2005) "Whole-cell voltage clamp measurements of anthrax protective antigen pores." J. Biol. Chem. 280: 39417.[Abstract] [Journal]

 17. Krantz BA, Melnyk RA, Zhang S, Juris SJ, Lacy DB, Wu Z, Finkelstein A, Collier RJ. (2005) "A phenylalanine clamp catalyzes protein translocation through the anthrax toxin pore."Science309: 777. [Abstract] [Journal] [Supporting materials]

 2004

 16. Christensen KA, Krantz BA, Melnyk RA, Collier RJ. (2004) "Interaction of the 20 kDa and 63 kDa fragments of anthrax protective antigen: kinetics and thermodynamics." Biochemistry 44: 1047. [Abstract] [Journal]

 15. Sosnick TR, Dothager RS, Krantz BA. (2004) "Differences in the folding transition state of ubiquitin indicated by Φ- and Ψ-analyses." Proc. Natl Acad. Sci. 101: 17377. [Abstract] [Journal]

  • Commentary by Alan Fersht in Proc. Natl Acad. Sci. 101: 17327. [Pubmed] [Journal]

 14. Krantz BA, Trivedi AD, Cunningham K, Christensen KA, Collier RJ. (2004) "Anthrax toxin's lethal and edema factors unfold under acidic pH conditions." J. Mol. Biol. 344: 739.[Abstract] [Journal]

 13. Pimental RA, Christensen KA, Krantz BA, Collier RJ. (2004) "Anthrax toxin complexes: heptameric protective antigen can bind lethal factor and edema factor simultaneously." Biochem. Biophys. Res. Commun. 322: 258. [Abstract] [Journal] 

 12. Wigelsworth DJ, Krantz BA, Christensen KA, Lacy DB, Juris SJ, Collier RJ. (2004) "Binding stoichiometry and kinetics of the interaction of a human anthrax toxin receptor, CMG2, with protective antigen." J. Biol. Chem. 279: 23349. [Abstract] [Journal]

 11. Jacob J, Krantz B, Dothager RS, Thiyagarajan P, Sosnick TR. (2004) "Early collapse is not an obligate step in protein folding." J. Mol. Biol. 338: 369. [Abstract] [Journal] 

 10. Krantz BA, Dothager R, Sosnick TR. (2004) "Discerning the structure and energy of multiple transition states in protein folding using Ψ-analysis." J. Mol. Biol. 337: 463. [Abstract] [Journal] 

  • Erratum (2005): J. Mol. Biol. 347: 1103. [Journal] 

 2002

 Krantz, BA. (2002) Protein folding: new methods unveil rate-limiting structures. Ph.D. diss. University of Chicago. [PDF]

 9. Krantz BA, Mayne L, Rumbley J, Englander SW, Sosnick TR. (2002) "Fast and slow intermediate accumulation and the initial barrier mechanism in protein folding." J. Mol. Biol. 324: 359.[Abstract] [Journal]

 8. Krantz BA, Srivastava AK, Nauli S, Baker D, Sauer RT, Sosnick TR. (2002) "Understanding protein hydrogen bond network formation with kinetic D/H amide isotope effects." Nature Struct. Biol. 9: 458. [Abstract] [Journal] [PDF]

 7. Shi Z, Krantz BA, Kallenbach N, Sosnick TR. (2002) "Contribution of hydrogen bonding to protein stability estimated from isotope effects." Biochemistry. 41: 2120. [Abstract][Journal] [PDF]

 2001

 6. Krantz BA, Sosnick TR. (2001) "Engineered metal binding sites map the heterogeneous folding landscape of a coiled coil." Nature Struct. Biol. 8: 1042. [Abstract] [Journal] [PDF]

 5. Yin L, Krantz B, Russell NS, Deshpande S, Wilkinson KD. (2000) "Nonhydrolyzable diubiquitin analogues are inhibitors of ubiquitin conjugation and deconjugation." Biochemistry. 39: 10001. [Abstract] [Journal]

 2000

 4. Krantz BA, Sosnick TR. (2000) "Distinguishing between two-state and three-state models for ubiquitin folding." Biochemistry. 39: 11696. [Abstract] [Journal] [PDF]

 3. Krantz BA, Moran LB, Kentsis A, Sosnick TR. (2000) "D/H amide kinetic isotope effects reveal when hydrogen bonds form during protein folding." Nature Struct. Biol. 7: 62. [Abstract][Journal] [PDF]

 1998

 2. Larsen CN, Krantz BA, Wilkinson KD. (1998) "Substrate specificity of deubiquitinating enzymes: ubiquitin C-terminal hydrolases." Biochemistry. 37: 3358. [Abstract] [Journal]

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 1997

 1. Amerik AYu, Swaminathan S, Krantz BA, Wilkinson KD, Hochstrasser M. (1997) "In vivo disassembly of free polyubiquitin chains by yeast Ubp14 modulates rates of protein degradation by the proteasome." EMBO J. 16: 4826. [Abstract] [Journal]