Selected Publications and Patents

  1. Zhang Y, Saint Fleur A, Feng H., The development of live biotherapeutics against Clostridioides difficile infection towards reconstituting gut microbiota. Gut Microbes. 2022; 14(1):2052698.  
  2. Chen K, Zhu Y, Zhang Y, Hamza T, Yu H, Saint Fleur A, Galen J, Yang Z, Feng H.A probiotic yeast-based immunotherapy against Clostridium difficile infection. Science translational medicine. 2020; 12(567), eaax4905. 
  3. Zhang Y, Li S, Yang Z, Shi L, Yu H, Salerno-Goncalves R, Saint Fleur A, Feng H. Cysteine Protease-Mediated Autocleavage of Clostridium difficile Toxins Regulates Their Proinflammatory Activity. Cell Mol Gastroenterol Hepatol. 2018; 5(4):611-625. 
  4. Zhang Y, Yang Z, Gao S, Hamza T, Yfantis H, Lipsky M, Feng H. The role of purified Clostridium difficile glucosylating toxins in disease pathogenesis utilizing a murine cecum injection model. Anaerobe 2017; S1075-9964(17):30201-9. 
  5. Yang Z, Zhang Y, Huang T, Feng H. Glucosyltransferase activity of Clostridium difficile Toxin B is essential for disease pathogenesis. Gut Microbes. 2015; 6(4):221-4. 
  6. Zhang Y, Hamza T, Gao S, Feng H. Masking autoprocessing of Clostridium difficile toxin A by the C-terminus combined repetitive oligo peptides. Biochem Biophys Res Commun. 2015; 459(2):259-263.  
  7. Zhang Y, Shi L, Li S, Yang Z, Standley C, Yang Z, ZhuGe R, Savidge T, Wang X, Feng H. A segment of 97 amino acids within the translocation domain of Clostridium difficile toxin B is essential for toxicity. PLoS One. 2013; 8(3):e58634.  
  • Hanping Feng, Yongjun Guan, Yongrong Zhang, Zhiyong Yang, Lianfa Shi. 2016.  Tetra-specific, octameric binding agents and antibodies against Clostridium difficile toxin A and toxin B for treatment of C. difficile infection. US Patent 20180244760, filed on Februray 5, 2016, and issued on August 30, 2018. 
  • Hua Yu, Hanping Feng, Zhiyong Yang, Yongrong Zhang, Yifan Zhang. 2020. Humanized tetra-specific octavalent antibody against Clostridium difficile toxin A and B. WO2020247500A1, filed on 2020-06-03, published on 2020-12-10 
  • Hua Yu, Hanping Feng, Zhilei Chen, Rudo Simeon, Yongrong Zhang, Ana Chamoun-emanuelli, Zeyu Peng. 2020. Protein inhibitors of Clostridium difficile toxin B. WO2020231930A1, filed on 2020-05-11, published on 2020-11-19