Selected Peer-Reviewed Publications

Selected Peer-Reviewed Publications

  • Lack of evidence for vasoactive and inflammatory mediators in the promotion of macular edema associated with epiretinal membranes. Applewhite BP, Babapoor-Farrokhran S, Poon D, Hassan SJ, Wellmann E, Ying HS, Semenza GL, Montaner S, Sodhi A. Sci Rep. 2017 6;7(1):10608.

  • Hypoxia-inducible factor-dependent expression of angiopoietin-Like 4 by conjunctival epithelial cells promotes the angiogenic phenotype of pterygia. Meng Q, Qin Y, Deshpande M, Kashiwabuchi F, Rodrigues M, Lu Q, Ren H, Elisseeff JH, Semenza GL, Montaner S, Sodhi A. Invest Ophthalmol Vis Sci. 2017 58(11):4514-4523
  • Expression of the angiogenic mediator, angiopoietin-like 4, in the eyes of patients with proliferative sickle retinopathy. Jee K, Rodrigues M, Kashiwabuchi F, Applewhite BP, Han I, Lutty G, Goldberg MF, Semenza GL, Montaner S, Sodhi A. PLoS One. 2017 12(8):e0183320.
  • Expression of angiogenic mediators in a patient with a retinal artery occlusion. Babapoor-Farrokhran S, Poon D, Solomon S, Montaner S, Sodhi A. Can J Ophthalmol. 2017 52(4):e122-e125.
  • Expression Pattern of HIF-1alpha and VEGF supports circumferential application of scatter laser for proliferative sickle retinopathy. Rodrigues M, Kashiwabuchi F, Deshpande M, Jee K, Goldberg MF, Lutty G, Semenza GL, Montaner S, Sodhi A. Invest Ophthalmol Vis Sci. 2016 57(15):6739-6746.

  • Hypoxia-inducible factor 1 upregulation of both VEGF and ANGPTL4 is required to promote the angiogenic phenotype in uveal melanoma. Hu K, Babapoor-Farrokhran S, Rodrigues M, Deshpande M, Puchner B, Kashiwabuchi F, Hassan SJ, Asnaghi L, Handa JT, Merbs S, Eberhart CG, Semenza GL, Montaner S, Sodhi A. Oncotarget. 2016 7(7):7816-28.
  • Angiopoietin-like 4 is a potent angiogenic factor and a novel therapeutic target for patients with proliferative diabetic retinopathy. Babapoor-Farrokhran S, Jee K, Puchner B, Hassan SJ, Xin X, Rodrigues M, Kashiwabuchi F, Ma T, Hu K, Deshpande M, Daoud Y, Solomon S, Wenick A, Lutty GA, Semenza GL, Montaner S, Sodhi A. Proc Natl Acad Sci U S A. 2015 112(23):E3030-9.  
  • KSHV induces aerobic glycolysis and angiogenesis through HIF-1-dependent upregulation of pyruvate kinase 2 in Kaposi's sarcoma. Ma T, Patel H, Babapoor-Farrokhran S, Franklin R, Semenza GL, Sodhi A, Montaner S. Angiogenesis. 2015 18(4):477-88. 
  • Hypoxic retinal Muller cells promote vascular permeability by HIF-1-dependent up-regulation of angiopoietin-like 4. Xin X, Rodrigues M, Umapathi M, Kashiwabuchi F, Ma T, Babapoor-Farrokhran S, Wang S, Hu J, Bhutto I, Welsbie DS, Duh EJ, Handa JT, Eberhart CG, Lutty G, Semenza GL, Montaner S, Sodhi A. Proc Natl Acad Sci U S A. 2013 110(36):E3425-34.
  • Activation of the Akt/mTOR pathway in dentigerous cysts, odontogenic keratocysts, and ameloblastomas. Chaisuparat R, Yodsanga S, Montaner S, Jham BC. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 116(3):336-42.
  • Regression of choroidal neovascularization in response to systemic chemotherapy for cancer. Hsu AW, Sodhi A, Eberhart C, Montaner S, Goldberg MF. Can J Ophthalmol. 2013 48(4):e80-2.
  • Scleral penetration of an unusually aggressive case of a retinal hemangioblastoma. Rodrigues M, Iliff NT, Eberhart CG, Montaner S, Sodhi A. Can J Ophthalmol. 2013 48(4):e67-71.
  • VEGF Secreted by Hypoxic Müller Cells Induces MMP-2 Expression and Activity in Endothelial Cells to Promote Retinal Neovascularization in Proliferative Diabetic Retinopathy. Rodrigues M, Xin X, Jee K, Babapoor-Farrokhran S, Kashiwabuchi F, Ma T, Bhutto I, Hassan SJ, Daoud Y, Baranano D, Solomon S, Lutty G, Semenza GL, Montaner S, Sodhi A. Diabetes. 2013 62(11):3863-73.
  • Amplification of the Angiogenic Signal through the Activation of the TSC/mTOR/HIF Axis by the KSHV vGPCR in Kaposi’s Sarcoma. Jham BC, Ma T, Hu J, Chaisuparat R, Friedman ER, Pandolfi PP, Schneider A, Sodhi A and Montaner S. PLoS ONE. 2011 6(4): e19103.
  • Angiopoietin-like 4: A Novel Molecular Hallmark in Oral Kaposi’s Sarcoma. Hu J, Jham BC, Ma T, Friedman ER, Ferreira L, Wright JM, Accurso B, Allen CM, Basile JR and Montaner S. Oral Oncology. 2011 47(5):371-5.
  • Viral G protein-coupled receptor up-regulates Angiopoietin-like 4 promoting angiogenesis and vascular permeability in Kaposi’s sarcoma. Ma T, Jham BC, Hu J, Friedman ER, Basile JR, Molinolo A, Sodhi A and Montaner S. Proceedings of the National Academy of Sciences of USA. 2010 107(32):14363-8.
  • Dual inhibition of PI3Kα and mTOR as an alternative treatment for Kaposi’s sarcoma. Chaisuparat R, Hu J,Jham BC, Knight ZA, Shokat KM and Montaner S. Cancer Research, 2008 68:8361-8.
  • A NF-κB gene expression signature contributes to Kaposi’s Sarcoma Virus vGPCR-induced direct and paracrine neoplasia. Martin D, Galisteo R, Ji Y, Montaner S and Gutkind, JS. Oncogene, 2008 27:1844-52.
  • Sulindac induces apoptosis and inhibits tumor growth in vivo in head and neck squamous cell carcinoma. Scheper MA, Nikitakis NG, Chaisuparat R, Montaner S and Sauk JJ. Neoplasia, 2007 9,192-9.
  • The TSC2/mTOR pathway drives endothelial cell transformation induced by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor. Sodhi, A., Chaisuparat, R., Hu, J., Ramsdell, A.K., Manning, B.D., Sausville, E.A., Sawai, E.T., Molinolo, A., Gutkind, J.S. and Montaner, S. Cancer Cell, 2006 10, 133-43.
  • The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor as a therapeutic target for the treatment of Kaposi's sarcoma. Montaner S, Sodhi A, Ramsdell AK, Martin D, Hu J, Sawai ET, Gutkind JS. Cancer Research, 2006 66, 168-74. *Corresponding author.
  • The small GTPase Rac1 Links the Kaposi’s Sarcoma Associated Herpesvirus vGPCR to Cytokine Secretion and Paracrine Neoplasia. Montaner, S., Sodhi, A., Servitja, J.M., Ramsdell, A.K., Barac, A., Sawai, E.T. and Gutkind, J.S. Blood, 2004 104, 2903-2911.
  • MAPK and Akt Act Cooperatively but Independently on Hypoxia Inducible Factor-1α in rasV12 upregulation of VEGF. Sodhi, A., Montaner, S., Miyazaki, H. and Gutkind, J.S. Biochemical and Biophysical Research Communications, 2001 287, 292-300.
  • The Kaposi’s Sarcoma-associated Herpesvirus G Protein-coupled Receptor Promotes Endothelial Cell Survival through the Activation of Akt/Protein kinase B. Montaner, S., Sodhi, A., Pece, S., Mesri, E.A. and Gutkind, J.S. Cancer Research, 2001 61, 2641-2648.
  • The Kaposi’s Sarcoma Associated Herpesvirus G Protein-Coupled Receptor upregulates VEGF Expression and Secretion through MAPK and p38 Pathways acting on HIF-1α. Sodhi, A., Montaner, S., Patel, V., Zohar, M., Bais, C., Mesri, E.A. and Gutkind, J.S. Cancer Research, 2000 60, 4873-4880.
  • Activation of the Serum Response Factor by RhoA is mediated by the nuclear factor kB and C/EBP transcription factors. Montaner, S., Perona, R., Saniger, L. and Lacal, J.C. Journal of the Biological Chemistry, 1999 274, 8506-8515.
  • Multiple Signalling Pathways Lead to the Activation of the Nuclear Factor kB by the Rho Family of GTPases. Montaner, S., Perona, R., Saniger, L. and Lacal, J.C. Journal of the Biological Chemistry, 1998  273, 12779-12785.
  • The Small GTP-Binding Protein Rho Links G Protein-Coupled Receptors and Gα12 to the Serum Response Element and to Cellular Transformation. Fromm, C., Coso, O.A., Montaner, S., Xu, N. and Gutkind, J.S. Proceedings of the National Academy of Sciences of USA, 1997 94, 10098-10103.
  • Signaling from G Protein-Coupled Receptors to the c-Jun Promoter Involves the MEF2 Transcription Factor: Evidence for a Novel JNK- Independent Pathway. Coso, O.A., Montaner, S., Fromm, C., Lacal, J.C., Prymes, R., Teramoto, H. and Gutkind, J.S. Journal of the Biological Chemistry, 1997 272, 20691-20697.
  • Activation of the Nuclear Factor kB by Rho, Cdc42 and Rac 1 Proteins”. Perona, R.,* Montaner, S.,* Saniger, L., Sanchez-Perez, I., Bravo, R. and Lacal, J.C. Genes & Development, 1997 11,  463-475. * Equal contribution.
  • Overexpression of PKCg in NIH3T3 Cells Does Not Induce Cell Transformation nor Tumorigenicity and Does Not Alter NFkB Activity. Montaner, S., Ramos, A., Perona, R., Esteve, P., Carnero, A. and Lacal, J.C. Oncogene, 1995 10, 2213-2220.
  • Generation of Phosphorylcholine as an Essential Event in the Activation of Raf-1 and MAP-Kinases in Growth Factors-Induced Mitogenic Stimulation. Jimenez, B., Del Peso, L., Montaner, S., Esteve, P. and Lacal, J.C. Journal of Cellular Biochemistry, 1995 57, 141-149. 
Selected Invited Reviews
  • Angiopoietin-like 4 as a potential therapeutic target for head and neck squamous cell carcinoma. Montaner, S. Journal of Dentistry and Oral Biology. In press. 2017
  • Angiopoietin-like 4 as an emerging therapeutic target for diabetic eye disease. Sodhi A, Montaner S. JAMA Ophthalmology. 2015. 133(12):1375-6.
  • Molecular mechanisms deployed by virally encoded G protein-coupled receptors in human diseases. Montaner S*, Kufareva I, Abagyan R, Gutkind JS. Annual Review of Pharmacology and Toxicology, 2013 53:331-54.  *Corresponding author.
  • The Kaposi’s Sarcoma-Associated Herpesvirus G Protein Coupled Receptor: Lessons on Dysregulated Angiogenesis from a Viral Oncogene. Jham, BC and Montaner, S. Journal of Cellular Biochemistry, 2010 110(1):1-9.
  • Akt/TSC/mTOR activation by the KSHV G protein-coupled receptor: Emerging insights into the molecular oncogenesis and treatment of Kaposi's sarcoma. Montaner, S. Cell Cycle. 2007 6, 438-43.
  • Viral Hijacking of G-Protein-Coupled-Receptor Signalling Networks. Sodhi, A., Montaner, S.* and Gutkind, J.S.* Nature Reviews, Molecular and Cellular Biology. 2004 5, 998-1012.  *Corresponding author.
  • Does dysregulated expression of a deregulated viral GPCR trigger Kaposi's sarcomagenesis?. Sodhi, A., Montaner, S. and Gutkind, J.S. FASEB Journal, 2004 18, 422-427.