Orthodontic Research

Jose A. Bosio, BDS, MS - jbosio@umaryland.edu
  • Openbite and tongue posture/thrust problems
  • Tooth size discrepancy - Esthetics
  • Palatal expansion - BOKA grading system
  • Postgraduate educational system
  • Temporomandibular Disorders

 Eung-Kwon Pae, DDS, MSc, PhD - epae@umaryland.edu

  • Obstructive sleep apnea
  • Perinatal intermittent hypoxia induced diabetes
  • Insulin production using stem cells from deciduous dental pulp
  • Openbite and tongue/hyoid muscle fiber types
  • Orthodontics - functional appliances

Monica Schneider, DDS - MSchneider@umaryland.edu

  • Sex differences in peripheral opioid receptor mechanisms
  • Accelerated tooth movement

Dina Stappert, DDS - dstappert@umaryland.edu

  • Biology of tooth movement
  • Evaluation of efficacy of orthodontic diagnostics for idiopathic condylar resorption

Vocal Tract Visualization Laboratory

Maureen L Stone, PhDmstone@umaryland.edu

  • Map tongue muscle activity to tongue surface motion.
  • Tongue-jaw-palate interaction in speech and swallowing production.
  • Imaging techniques used to analyze tongue motion (ultrasound, tagged cine-MRI)
  • Swallowing
  • Speech Production

Recent Publications

University of Maryland - Division of Orthodontics Scientific Contribution
From July 1st- 2016-December 2017
    Barron Bosio Pae Posnick Schneider Stappert Stone Williams Subtotal Total
Books         2           2
Book Chapters         6           6
Peer Review Papers Published 1 6 6 10     6   38 29
Accepted   2     2       4
Submitted   4         1   5
Grants Awarded             1   5 1
Submitted   1 2           3
In preparation           1     1
Patent  awarded                 1 0
application   1             1
Abstract/Posters accepted   7     1 2     11 10
Submitted   1             1
Presentations Local   1 1   2       16 4
National 2 1 3       3   9
International   3             3
Meetings / Conferences Attended Local   9             19 9
National   4 1   1 1   2 9
International   1             1
Total   3 41 13   6 4 11 2   80

 

  1. Grants, Contracts, and Awards

1.1.      Lee S, Lee C, Melo MAS, Bosio JA: NIH-RO1- GRANT12516631. A High Precision Oral Capacitive Sensor for Real Time Measurement of Multimode Orthodontic Forces. Baltimore, MD. Submitted on 11/06/2017.

1.2.      New Leadership Conference. Ft. Lauderdale, FL – U$ 1100.00, Awarded by: American Association of Orthodontists, St. Louis, MO Date: 02/08-10/2017. Bosio JA

1.3.      American Board of Orthodontics digital cast evaluation validation using iTero intraoral scanner and Invisalign treatment. 04/16. $24,979.90. Bosio JA Not granted.

1.4.      American Association of Orthodontists Foundation Biomedical Research Award Total: $25,000. 2013 Project ongoing by M Schneider: “Accelerated Space Closure in Adult Patients”

1.5.      NIH R01CA133015  “Predictors of Speech Quality after Tongue Cancer Surgery  Score: 115 Percentile: 1.9%. 5/1/2009 – 4/30/2015.    Total Award: $3,365,000.  P.I. Maureen Stone.  Study and model the effect of surgical and subject based factors on compensatory tongue motion and speech quality after tongue cancer surgery.

1.6.         European Union Grant agreement no: 600676  1/1/2013-12/31/2015 "Intangible Treasures - Capturing the Intangible Cultural Heritage and Learning the Rare Know-How of Living Human Treasures." (i-Treasures)

1.7.      NIH R01DC014747 “Tongue Muscle Function After Cancer Surgery Using 4D MRI, DTI, and MR tagging” 8/7/2015-7/31/2020. Total Award: $1,659,314 (DC). P.I. Jerry Prince. Examine stress tensors in DTI and tagging to relate fiber direction to fiber shortening of tongoue muscles. (Subcontract to UM $679,622(DC)– P.I.: Maureen Stone)

 

  1. Publications

2018

Freitas BV, Frazão MCA, Dias L, dos Santos PCF, Freitas HV, Bosio JA: Non-surgical correction of a severe anterior open bite achieved by mandibular molar intrusion using mini-implants and MEAW technique. In Print AJODO-D-16-00631. 02/2018.

Rodrigues VP, Freitas L, Bosio JA, Oliveira JZ, Freitas BV, dos Santos, PCF: Tooth loss and craniofacial factors associated with changes in mandibular condyle morphology. Cranio. Accepted CRN539R1. Jan 2018.

Battle Y, Schneider M, Magder L, Pae EK. Disparity in opinions on lip protrusiveness in contemporary African American faces. Korean J Orthod. 2018 Jan;48(1):23-29. doi: 10.4041/kjod.2018.48.1.23. Epub 2017 Nov 19.

Luis E Almeida, Adam Sorenson, Kyle Hresko, Seth Butcher, Rosalia, Leonardi, Carla Loreto, Jose Bosio, Lobat Tayebi & Andrea Doetzer (2018): Immunohistochemical analysis of IL-1 Receptor 1 in the discs of patients with temporomandibular joint dysfunction, CRANIO®, DOI: 10.1080/08869634.2017.1417765.

Kim G, Shin KH, Pae E* (2016) Zinc up-regulates insulin secretion from β cell-like cells derived from dental pulp stem cells. Inter J of Mol Sci. for Special Issue "Zinc Signaling in Physiology and Pathogenesis. Int J Mol Sci. 3;17(12). pii: E2092. PMID:27983594

Chen L, Zahra HZ, Zhang J, Scharf SM, Pae E* (2018) Intermittent hypoxia in utero damages postnatal growth and cardiovascular function in rats. J Appl Physiol, In Print. https://doi.org/10.1152/japplphysiol.01066.2016

Battle Y, Schneider M, Magder L, Pae E* (2018) Disparity in Opinions on Lip Protrusiveness among Modern African American Faces. Korean J Orthod. 2018 Jan; 48(1):23-29. doi: 10.4041/kjod.2018.48.1.23. Epub 2017 Nov 19. PMID: 29291185

Kim G, Zhao X, Chung M, Joseph J, Pae E* (2018) Intracellular chloride levels regulate insulin secretion following immediate postnatal intermittent hypoxia. Front Cell Neurosci., Under Revision.

Book Chapter. Pae E (2018) Perinatal OSA results in fragile bone. Monograph, Sleep Apnea: What Every Clinician (and Patient) Should Know. Volume 53 of the Craniofacial Growth Series. Department of Orthodontics and Pediatric Dentistry, School of Dentistry; and Center for Human Growth and Development, University of Michigan, Ann Arbor, MI

2017

Orlando, Tanaka OM, Bosio JA: Class II Division 2, subdivision malocclusion in adult patient treated with unilateral Forsus fatigue resistance device. J Orthod. Submitted in Dec, 2017.

Gingival Clefts Revisited – A Prospective Study on Clinical Characteristics Associated with Cleft Formation. Stappert D, Geiman R, Heidari Z, Reynolds M. AJODO (Accepted for publication November 2018)

Jarosz KF, Bosio JA, Bloomstein R, Jiang SS, Vakharia NS, Cangialosi TJ: Perceptions of Chin Asymmetries amongst Dental Professionals and Laypersons, Accepted AJODO in Nov, 2017

Bogle S, Bosio JA, Jiang SS, Cangialosi TJ: United States and Canadian Orthodontic Faculty Satisfaction Survey. Accepted to JDE in Dec/2017.

Sorenson A, Hresko K, Butcher S, Pierce S, Tramontina V, Leonardi R, Loreto C, Bosio JA, Almeida LE (2017): Expression of Interleukin-1 and temporomandibular disorder: Contemporary review of the literature, CRANIO®, DOI: 10.1080/08869634.2017.1342890.

Bósio JA, Del Santo M, Jacob HB. Odontologia digital contemporânea – scanners intraorais digitais. Orthod. Sci. Pract. 2017; 10(39):355-362. DOI: 10.24077/2017;1039-355362.

Jacob HB, Del Santo M, Bosio JA. Extrações ortodônticas de pré-molares e seus efeitos nas vias aéreas respiratórias superiores – revisão da literatura. (Orthodontic premolar extractions and their effects on oropharyngeal airway – literature review) Orthod. Sci. Pract. 2017; 10(37):106-111.

Bosio JA, Rozhitsky F, Jiang SS, Conte M, Mukherjee P, Cangialosi TJ: Comparison of scanning times for different dental cast materials using an intraoral scanner, J World Fed Orthod; 6 (2017) 11e14.

Harandi, N., Stavness, I, Woo, J. Stone, M., Abugharbieh, R., Fels, S,  (2017) Variability in Muscle Activation of Simple Speech Motions: A Biomechanical Modeling Approach. The Journal of the Acoustical Society of America, 141(4), pp.2579-2590. DOI: 10.1121/1.4978420

Harandi, N., Stavness, I, Woo, J. Stone, M., Abugharbieh, R., Fels, S,  (2017) Subject specific biomechanical modelling of the oropharynx: towards speech production. Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization, 5(6), 416–426, https://doi.org/10.1080/21681163.2015.1033756

Posnick JC, Adachie A, Singh N, Choi E, "Silent" Sleep Apnea in Dentofacial Deformities and Prevalence of Daytime Sleepiness after Orthognathic/Intranasal Surgery, Journal of Oral and Maxillofacial Surgery (2017), doi: 10.1016/j.joms.2017.09.003.

Posnick JC, Choi, Chavda A: Method of Osteotomy Fixation and need for Removal Following Bimaxillary Orthognathic, Osseous Genioplasty, and Intranasal Surgery: A Retrospective Cohort Study. Int J Oral Maxillofac Surg; 46: 1276-1283, 2017.

Posnick JC, Choi E, Chavda A: Surgical Site Infections Following Bimaxillary Orthognathic, Osseous Genioplasty, and Intranasal Surgery: A Retrospective Cohort Study.  J Oral Maxillofac Surg 75:584-595, 2017.

Posnick JC, Perez J, Chavda A: Hemi-Mandibular Elongation: Is the Corrected Occlusion Maintained Long-Term? Does the Mandible Continue to Grow?  J Oral Maxillofac Surg 75:371-398, 2017.

2016

Del Santo M; Jacob H; Bósio JA: The challenge of the orthodontic treatment of the hyperdivergent facial phenotype patient. Rev Assoc Paul Cir Dent 2016;70(1):76-81.

Wright J, Bosio JA, Chou, J-C, Jiang SS: Maxillary lateral incisors agenesis and its relationship to overall tooth size. J Prosth Dent, 2016;115:209-214.

Kim G, Elnabawi O, Shin D, Pae EK. Transient Intermittent Hypoxia Exposure Disrupts Neonatal Bone Strength. Front Pediatr. 2016 Mar 7;4:15. doi: 10.3389/fped.2016.00015. eCollection 2016.

Nguyen D, Kim G, Pae E* (2016) Modulation of Skeletal Muscle Fiber-types in Response to Hypoxia via Pyruvate Dehydrogenase Kinase-1. Front Physiol. 15;7: 604. doi: 10.3389/fphys.2016.00604.

Kim G, Shin KH, Pae E* (2016) Zinc up-regulates insulin secretion from β cell-like cells derived from dental pulp stem cells. Inter J of Mol Sci. for Special Issue "Zinc Signaling in Physiology and Pathogenesis. Int J Mol Sci. 3;17(12). pii: E2092. PMID:27983594

Ha, J, Sung, IY, Son, JH, Stone, M., Ord, R, Cho, YC, (2016) Analysis of speech and tongue motion in normal and post glossectomy speaker using cine MRI. Journal of Applied Oral Science, 24(5):472-80. http://dx.doi.org/10.1590/1678-775720150421

Xing, F., Woo, J., Lee, J., Murano, E. Z., Stone, M., & Prince, J. L. (2016). Analysis of 3-D Tongue Motion From Tagged and Cine Magnetic Resonance Images. Journal of Speech, Language, and Hearing Research, 59(3), 468-479.

Posnick JC, Choi E, Liu S: Occurrence of a “Bad” Split & Success of Initial Mandibular Healing: A Review of 524 Consecutive Sagittal Ramus Osteotomies.  Int J Oral Maxillofac Surg; 45:10, 1187-1194, 2016.

Posnick JC, Choi E, Singh N: Lingual Nerve Injury in Association with Sagittal Ramus Osteotomy and Bicortical Screw Fixation: A Review of 523 Procedures in 262 Subjects.  Int J Oral Maxillofac Surg 45: 1445-1451, 2016.

Posnick JC, Choi E, Chang RP: Osseous Genioplasty in Conjunction with Bimaxillary Orthognathic Surgery: A Review of 262 Consecutive Cases. Int J Oral Maxillofac Surg 45: 904-913, 2016.

Posnick JC, Adachie A, Choi E: Segmental Maxillary Osteotomies in Conjunction with Bimaxillary Orthognathic Surgery: Indications – Safety – Outcome. J Oral Maxillofac Surg, 74:1422-1440, 2016.

Posnick JC, Choi E, Chavda A: Operative Time, Airway Management, Need for Blood Transfusions, and In-Hospital Stay for Bimaxillary, Intranasal, and Osseous Genioplasty Surgery: Current Clinical Practices. J Oral Maxillofac Surg, J Oral Maxillfac Surg, 74:3. p. 590-600, March 2016.

Posnick JC, Choi E, Adachie A, Troost T: Correction of Symptomatic Chronic Nasal Airway Obstruction in Conjunction with Bimaxillary Orthognathic Surgery: Does it Complicate Recovery and is it Effective?  J Oral Maxillofac Surg, 74: 3.e1-620.e11, March 2016

Zhao X, Deng P, Feng J, Wang Z, Xiang Z, Han X, Bai D, Pae E* (2016) Cysteine Dioxygenase Type 1 Inhibits Osteogenesis by Regulating Wnt Signaling in Primary Mouse Bone Marrow Stromal Cells. Sci Rep 6:19296. doi: 10.1038/srep19296.

2015

Stappert D, Warburton G. Recognition of Idiopathic Condylar Resorption as a Diagnostic Possibility in an Academic Orthodontic Clinic. J of Ortho and Endo. Vol.1 2:14, 2015

Bosio JA (2015) Will I ever be a good teacher? The Angle Orthodontist: November 2015, Vol. 85, No. 6, pp. 1080-1081.

Ye, C, Murano, E, Stone, M and Prince, JL. (2015) A Bayesian approach to distinguishing interdigitated tongue muscles from limited diffusion magnetic resonance imaging.  Computerized Medical Imaging and Graphics 45:63–74.

Posnick JC, Gray JA: Is It Safe to Re-Harvest the Anterior Iliac Crest to Manage Le Fort I Interpositional Defects in Young Adults with a Repaired Cleft? J Oral Maxillofac Surg 73:S32-S39, 2015.

Posnick JC, Sami A: Individuals With a Long Face Growth Pattern and Excess Inferior Scleral Exposure: Is There Improvement After Maxillary (Le Fort I) Advancement and Vertical Shortening? J Oral Maxillofac Surg 73:1809-1815, 2015.

Posnick JC, Sami A: Use of Allogenic (Iliac) Corticocancellous Graft for LeFort I Interpositional Defects: Technique and Results. J Oral Maxillofac Surg 73:168.e1, 2015.

  1. Stone, M, Liu, X, Zhuo, J, Gullapalli, R, Salama, A and Prince, JL (2009) Principal Component Analysis of Internal Tongue Motion in Normal and Glossectomy patients with primary Closure and Free Flap. Proceedings of the Fifth B-J-K International Symposium on Biomechanics Healthcare and Information Science, Feb. 20-22, 2009, Kanazawa, Japan. PDF
  2. Shinagawa, H, Murano, EZ, Zhuo, J, Landman, B, Gullapalli, RP, Prince, JL, Stone, M (2008) Human tongue muscle fiber tracking during rest and tongue protrusion with oral appliance: A preliminary study with diffusion tensor imaging., Acoust. Sci & Tech 29(4), 291-294. PDF
  3. Stone M, Liu X, Shinagawa, H, Murano EZ, Gullapalli R, Zhuo J, Prince J. (2008) Speech patterns in a muscular hydrostat: muscle movement in a glossectomy flap patient. Proceedings of the Fourth B-J-K Symposium on Biomechanics, Healthcare and Information Science, March 13-14, 2008, Kanazawa, Japan. PDF
  4. Stone, M., Stock, G., Bunin, K., Kumar, K., Epstein, M., Parthasarathy,V., Prince, J, Li, M., Kambhamettu, C. (2007) Comparison of speech production in upright and supine position . J. Acoust. Soc. Am., 122(1), 532-541 PDF
  5. Stone, M., and Murano, E.Z. (2007) Speech patterns in a muscular hydrostat: normal and glossectomy tongue movement. Proceedings of the Third B-J-K Symposium on Biomechanics, Healthcare and Information Science. p. 137-154 , March 16-17, 2007, Kanazawa, Japan. PDF
  6. Li, M., Kambhamettu, C., and Stone, M. (2007) Nonrigid motion recovery for 3D surfaces. Image and Video Computing., 25, 250-261
  7. Liu, X., Murano, E., Stone, M., and Prince, J.L., (2007), “HARP tracking refinement using seeded region growing,” Proc. Int’l Symp Biomed Imaging (ISBI). PDF