Dr. Fernandes do Espírito Santo

  1. São Pedro A, Fernandes R, Villarreal CF, Fialho R, Albuquerque EC. Opioid-based micro and nanoparticulate formulations: alternative approach on pain management. J Microencapsul. 2016 Feb;33(1):18-29. doi: 10.3109/02652048.2015.1134687. Epub 2016 Jan 20. PMID: 26786722.

  2. Nascimento OA, Espírito-Santo RF, Opretzka LC, Barbosa-Filho JM, Gutierrez SJ, Villarreal CF, Soares MB. Pharmacological Properties of Riparin IV in Models of Pain and Inflammation. 2016 Dec 21;21(12):1757. doi: 10.3390/molecules21121757. PMID: 28009853.

  3. Soares AP, do Espírito Santo RF, Line SR, Pinto Md, Santos Pde M, Toralles MB, do Espírito Santo AR. Bisphosphonates: Pharmacokinetics, bioavailability, mechanisms of action, clinical applications in children, and effects on tooth development. Environ Toxicol Pharmacol. 2016 Mar;42:212-7. doi: 10.1016/j.etap.2016.01.015. Epub 2016 Jan 22. PMID: 26895384.

  4. Soares AP, do Espírito Santo RF, Line SR, Pinto Md, Santos Pde M, Toralles MB, do Espírito Santo AR. Effects of Pamidronate on Dental Enamel Formation Assessed by Light Microscopy, Energy-Dispersive X-Ray Analysis, Scanning Electron Microscopy, and Microhardness Testing. Microsc Microanal. 2016 Jun;22(3):640-8. doi: 10.1017/S1431927616000726. Epub 2016 May 23. PMID: 27212049.

  5. Moreira DRM, Santos DS, Espírito Santo RFD, Santos FED, de Oliveira Filho GB, Leite ACL, Soares MBP, Villarreal CF. Structural improvement of new thiazolidinones compounds with antinociceptive activity in experimental chemotherapy-induced painful neuropathy. Chem Biol Drug Des. 2017 Aug;90(2):297-307. doi: 10.1111/cbdd.12951. Epub 2017 Feb 22. PMID: 28112878.

  6. Meira CS, Espírito Santo RFD, Dos Santos TB, Orge ID, Silva DKC, Guimarães ET, Aragão França LS, Barbosa-Filho JM, Moreira DRM, Soares MBP. Betulinic acid derivative BA5, a dual NF-kB/calcineurin inhibitor, alleviates experimental shock and delayed hypersensitivity. Eur J Pharmacol. 2017 Nov 15;815:156-165. doi: 10.1016/j.ejphar.2017.09.008. Epub 2017 Sep 9. PMID: 28899698.

  7. Espírito-Santo RF, Meira CS, Costa RDS, Souza Filho OP, Evangelista AF, Trossini GHG, Ferreira GM, Velozo EDS, Villarreal CF, Pereira Soares MB. The anti-inflammatory and immunomodulatory potential of braylin: Pharmacological properties and mechanisms by in silico, in vitro and in vivo approaches. PLoS One. 2017 Jun 8;12(6):e0179174. doi: 10.1371/journal.pone.0179174. PMID: 28594906.

  8. Paz OS, de Jesus Pinheiro M, do Espirito Santo RF, Villarreal CF, Castilho MS. Nanomolar anti-sickling compounds identified by ligand-based pharmacophore approach. Eur J Med Chem. 2017 Aug 18;136:487-496. doi: 10.1016/j.ejmech.2017.05.035. Epub 2017 May 12. PMID: 28528302.

  9. Lauria PSS, Casais-E-Silva LL, do Espírito-Santo RF, de Souza CMV, Zingali RB, Caruso MB, Soares MBP, Villarreal CF. Pain-like behaviors and local mechanisms involved in the nociception experimentally induced by Latrodectus curacaviensis spider venom. Toxicol Lett. 2018 Dec 15;299:67-75. doi: 10.1016/j.toxlet.2018.09.008. Epub 2018 Sep 24. PMID: 30261224.

  10. Abreu LS, Alves IM, Espírito Santo RFD, Nascimento YMD, Dantas CAG, Dos Santos GGL, Le Hyaric M, Guedes MLS, da Silva MS, Villarreal CF, Velozo EDS, Tavares JF. Antinociceptive compounds and LC-DAD-ESIMSn profile from Dictyoloma vandellianum leaves. PLoS One. 2019 Oct 29;14(10):e0224575. doi: 10.1371/journal.pone.0224575. PMID: 31661523.

  11. do Espírito Santo RF, Lima MDS, Juiz PJL, Opretzka LCF, Nogueira RC, Ribeiro IM, Tomassini TCB, Soares MBP, Villarreal CF. Physalis angulata concentrated ethanolic extract suppresses nociception and inflammation by modulating cytokines and prostanoids pathways. Nat Prod Res. 2019 Nov;35(22):4675-4679. doi: 10.1080/14786419.2019.1705812. Epub 2019 Dec 24. PMID: 31872780.

  12. Bomfim, L. M.: Espírito-Santo, R. F.; Quadros, H. C.; Orge, C. T. D. M.; Carneiro, R. T. O.; Magalhães, C. P.; Lima, F. R. Ensino por investigação em imunologia: As células de defesa e seus mecanismos efetores frente a doenças específicas. Atas de Ciências da Saúde, v. 7, p. 66-81, 2019.

  13. Meira CS, Santos ES, Santo RFDE, Vasconcelos JF, Orge ID, Nonaka CKV, Barreto BC, Caria ACI, Silva DN, Barbosa-Filho JM, Macambira SG, Moreira DRM, Soares MBP. Betulinic Acid Derivative BA5, Attenuates Inflammation and Fibrosis in Experimental Chronic Chagas Disease Cardiomyopathy by Inducing IL-10 and M2 Polarization. Front Immunol. 2019 Jun 11;10:1257. doi: 10.3389/fimmu.2019.01257. PMID: 31244833.

  14. Opretzka LCF, Espírito-Santo RFD, Nascimento OA, Abreu LS, Alves IM, Döring E, Soares MBP, Velozo EDS, Laufer SA, Villarreal CF. Natural chromones as potential anti-inflammatory agents: Pharmacological properties and related mechanisms. Int Immunopharmacol. 2019 Jul;72:31-39. doi: 10.1016/j.intimp.2019.03.044. Epub 2019 Apr 5. PMID: 30959369.

  15. Allahdadi KJ, de Santana TA, Santos GC, Azevedo CM, Mota RA, Nonaka CK, Silva DN, Valim CXR, Figueira CP, Dos Santos WLC, do Espirito Santo RF, Evangelista AF, Villarreal CF, Dos Santos RR, de Souza BSF, Soares MBP. IGF-1 overexpression improves mesenchymal stem cell survival and promotes neurological recovery after spinal cord injury. Stem Cell Res Ther. 2019 May 21;10(1):146. doi: 10.1186/s13287-019-1223-z. PMID: 31113444.

  16. Dos Santos Costa R, do Espírito-Santo RF, Abreu LS, de Oliveira Aguiar L, Leite Fontes D, Fechine Tavares J, Sobral da Silva M, Botelho Pereira Soares M, da Silva Velozo E, Flora Villarreal C. Fluorescent Canthin-6-one Alkaloids from Simaba bahiensis: Isolation, Identification, and Cell-Labeling Properties. Chempluschem. 2019 Mar;84(3):260-267. doi: 10.1002/cplu.201800591. Epub 2019 Feb 11. PMID: 31950762.

  17. VILLARREAL, CRISTIANE F. ; SANTOS, DOURIVALDO S. ; LAURIA, PEDRO S. S. ; GAMA, KELLY B. ; ESPÍRITO-SANTO, RENAN F. ; JUIZ, PAULO J. L. ; ALVES, CLAYTON Q. ; DAVID, JORGE M. ; SOARES, MILENA B. P.  Bergenin Reduces Experimental Painful Diabetic Neuropathy by Restoring Redox and Immune Homeostasis in the Nervous System. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 21, p. 4850, 2020.

  18. Silva P, de Almeida M, Silva J, Albino S, Espírito-Santo R, Lima M, Villarreal C, Moura R, Santos V. (E)-2-Cyano-3-(1H-Indol-3-yl)-N-Phenylacrylamide, a Hybrid Compound Derived from Indomethacin and Paracetamol: Design, Synthesis and Evaluation of the Anti-Inflammatory Potential. Int J Mol Sci. 2020 Apr 8;21(7):2591. doi: 10.3390/ijms21072591. PMID: 32276463.

  19. Vaz, N.O. ; Espírito-Santo, R. F.; Lima, L. M. M. ; Peixoto, L. P. ; Pinheiro, E. S. ; Teixeira, A. C. B. Benefícios do uso terapêutico de cannabidiol (cbd) em pacientes oncológicos: uma revisão sistemática da literatura. INTERNATIONAL JOURNAL OF DEVELOPMENT RESEARCH, v. 11, p. 21594, 2021.

  20. Dos Santos GGL, Oliveira ALL, Santos DS, do Espírito Santo RF, Silva DN, Juiz PJL, Soares MBP, Villarreal CF. Mesenchymal stem cells reduce the oxaliplatin-induced sensory neuropathy through the reestablishment of redox homeostasis in the spinal cord. Life Sci. 2021 Jan 15;265:118755. doi: 10.1016/j.lfs.2020.118755. Epub 2020 Nov 12. PMID: 33189826.

  21. Oliveira ALL, Santos GGL, Espirito-Santo RF, Silva GSA, Evangelista AF, Silva DN, Soares MBP, Villarreal CF. Reestablishment of Redox Homeostasis in the Nociceptive Primary Afferent as a Mechanism of Antinociception Promoted by Mesenchymal Stem/Stromal Cells in Oxaliplatin-Induced Chronic Peripheral Neuropathy. Stem Cells Int. 2021 Jan 6;2021:8815206. doi: 10.1155/2021/8815206. PMID: 33505472.

  22. Opretzka LCF, Freitas HF, Espírito-Santo RF, Abreu LS, Alves IM, Tavares JF, Velozo EDS, Castilho MS, Villarreal CF. 5-O-methylcneorumchromone K Exerts Antinociceptive Effects in Mice via Interaction with GABAA Receptors. Int J Mol Sci. 2021 Mar 26;22(7):3413. doi: 10.3390/ijms22073413. PMID: 33810317;

  23. Dos Santos GGL, Oliveira ALL, Santos DS, do Espírito Santo RF, Silva DN, Juiz PJL, Soares MBP, Villarreal CF. Mesenchymal stem cells reduce the oxaliplatin-induced sensory neuropathy through the reestablishment of redox homeostasis in the spinal cord. Life Sci. 2021 Jan 15;265:118755. doi: 10.1016/j.lfs.2020.118755. Epub 2020 Nov 12. PMID: 33189826.

  24. de Lima FO, Lauria PSS, do Espírito-Santo RF, Evangelista AF, Nogueira TMO, Araldi D, Soares MBP, Villarreal CF. Unveiling Targets for Treating Postoperative Pain: The Role of the TNF-α/p38 MAPK/NF-κB/Nav1.8 and Nav1.9 Pathways in the Mouse Model of Incisional Pain. Int J Mol Sci. 2022 Oct 1;23(19):11630. doi: 10.3390/ijms231911630. PMID: 36232927.

  25. E Silva JPR, Pereira LCO, Abreu LS, Lins FSV, de Souza TA, do Espírito-Santo RF, Barros RPC, Villarreal CF, de Melo JIM, Scotti MT, Costa VCO, Martorano LH, Dos Santos FM Jr, Filho RB, da Silva MS, Tavares JF. Targeted Isolation of Anti-inflammatory Lignans from Justicia aequilabris by Molecular Networking Approach. J Nat Prod. 2022 Sep 23;85(9):2184-2191. doi: 10.1021/acs.jnatprod.2c00478. Epub 2022 Aug 23. PMID: 35998343.

  26. da Silva PR, do Espírito Santo RF, Melo CO, Pachú Cavalcante FE, Costa TB, Barbosa YV, E Silva YMSM, de Sousa NF, Villarreal CF, de Moura RO, Dos Santos VL. The Compound (E)-2-Cyano-N,3-diphenylacrylamide (JMPR-01): A Potential Drug for Treatment of Inflammatory Diseases. 2022 Jan 13;14(1):188. doi: 10.3390/pharmaceutics14010188. PMID: 35057082.

  27. Lopes Araújo-Filho CE, Santos Galvão V, Fernandes do Espírito Santo R, de Souza Santos Monteiro A, Vargas Lordelo C, de Abreu Santos JC, Alves da Silva Junior V, Machado Cordeiro S, David Couto R. Nitrite-negative results in urinary tract infection by Enterobacterales: does the nitrite dipstick test have low sensitivity? J Med Microbiol. 2023 Feb;72(2). doi: 10.1099/jmm.0.001663. PMID: 36762527.

  28. Espírito-Santo, Renan Fernandes Do; Meira, Cássio Santana; Opretzka, Luiza Carolina França; Da Silva, Karoline Cristina Jatobá; De Araújo, Fênix Alexandra; Costa, Rafael Dos Santos; Velozo, Eudes Silva; Formiga, Fabio Rocha; Silva, Darizy Flávia; Soares, Milena Botelho Pereira; Villarreal, Cristiane Flora. Inhaled braylin regulates Th2 response and induces relaxant effects in the airway muscles in a model of ovalbumin-induced asthma. Phytomedicine Plus, v. 3, p. 100435, 2023.

  29. DO ESPÍRITO-SANTO, RENAN FERNANDES; SANTOS, DOURIVALDO SILVA ; SALES LAURIA, PEDRO SANTANA ; DE LIMA, ALYNE ALMEIDA ; ABREU, LUCAS SILVA ; TAVARES, JOSEAN FECHINE ; CASTILHO, MARCELO SANTOS ; PEREIRA SOARES, MILENA BOTELHO ; VILLARREAL, CRISTIANE FLORA. Tonantzitlolone B Modulates the Endogenous Opioid System to Promote Antinociception in Mice. JOURNAL OF NATURAL PRODUCTS, v. 86, p. 2514-2521, 2023.