Publications

RESEARCH PAPERS 

  1. Ohannes K. Melemedjian, Dipti V. Tillu, Jamie K. Moy, Marina N. Asiedu, Edward K. Mandell, Sourav Ghosh, Gregory Dussor and Theodore J. Price. 2014. Local translation and retrograde axonal transport of CREB regulates IL-6-induced nociceptive plasticity. Molecular Pain, 10:45.
  2. Sarah M. Wilson, Aubin Moutal, Ohannes K. Melemedjian, Yuying Wang, Weina Ju, Liberty Francois-Moutal, May Khanna and Rajesh Khanna. 2014. The functionalized amino acid (S)-Lacosamide subverts CRMP2-mediated tubulin polymerization to prevent constitutive and activity-dependent increase in neurite outgrowth. Frontiers in Cellular Neuroscience, 8:196.
  3. Xiaomei Wei, Ohannes K. Melemedjian, David D. Ahn, Nicole Weinstein and Gregory Dussor. 2014. Dural fibroblasts play a potential role in headache pathophysiology. Pain, 7, 1238-1244.
  4. Ohannes K. Melemedjian*, Galo L. Mejia, Talya S. Lepow, Olivia K. Zoph and Theodore J. Price. 2013. Bidirectional regulation of P body formation mediated by eIF4F complex formation in sensory neurons. Neuroscience Letters, 532, 169-174. *Co-corresponding authors
  5. Ohannes K. Melemedjian, Hussein N. Yassine, Adia Shy and Theodore J. Price. 2013. Proteomic and functional annotation analysis of injured peripheral nerves reveals ApoE as a protein upregulated by injury that is modulated by metformin treatment. Molecular Pain, 9:14.
  6. Ohannes K. Melemedjian, Dipti V. Tillu, Marina N. Asiedu, Edward K. Mandell, Caleb J. Taylor, Sourav Ghosh and Theodore J. Price. 2013. BDNF regulates PKMzeta at spinal synapses to initiate and maintain a centralized chronic pain state. Molecular Pain, 9:12.
  7. Ohannes K Melemedjian, Arkady Khoutorsky, Robert E Sorge, Jin Yan, Marina N Asiedu, Arely Valdez, Sourav Ghosh, Gregory Dussor, Jeffrey S Mogil, Nahum Sonenberg and Theodore J Price. 2013. mTORC1 inhibition induces allodynia and sensory neuron hyperexcitability via IRS1-dependent feedback activation of ERK. Pain, 154, 1080-1091.
  8. Tamara King, Chaoling Qu, Alec Okun, Ohannes K. Melemedjian, Edward K. Mandell, Irina Y. Maskaykina, Edita Navratilova, Gregory O. Dussor, Sourav Ghosh, Theodore J. Price and Frank Porreca. 2012. Contribution of PKMz-dependent and independent amplification to components of experimental neuropathic pain. Pain, 153, 1263-1273.
  9. Jin Yan, Ohannes K. Melemedjian, Theodore J. Price, and Gregory Dussor. 2012. Sensitization of dural afferents underlies the migraine-related behavior following meningeal application of interleukin-6 (IL-6). Molecular Pain, 8: 6.
  10. Dipti V. Tillu*, Ohannes K. Melemedjian*, Marina N. Asiedu, Ning Qu, Milena De Felice, Gregory Dussor, Theodore J. Price. 2012. Resveratrol engages AMPK to attenuate ERK and mTOR signaling in sensory neurons and inhibits incision-induced acute and chronic pain. Moecular Pain, 8(1):5.   *Co-first authors
  11. Ohannes K. Melemedjian, Marina N. Asiedu, Dipti V. Tillu, Raul Sanoja, Jin Yan, Arianna Lark, Arkaidi Khoutorsky, Jessica Johnson, Katherine A. Peebles, Talya Lepow, Nahum Sonenberg, Gregory Dussor and Theodore J. Price (2011). Targeting adenosine monophosphate-activated protein kinase (AMPK) in preclinical models reveals a potential mechanism for the treatment of neuropathic pain. Molecular Pain, 7: 70
  12. Marina N. Asiedu, Dipti V. Tillu, Ohannes K. Melemedjian, Adia Shy, Brice Bodell, Raul Sanoja, Frank Porreca, Theodore J. Price (2011). Spinal PKMz underlies the maintenance mechanism of persistent nociceptive sensitization. Journal of Neuroscience, 18:6646-6653.
  13. Ohannes K. Melemedjian, Marina N. Asiedu, Dipti V. Tillu, Katherine A. Peebles, Jin Yan, Natalie Ertz, Gregory O. Dussor, and Theodore J. Price (2010). IL-6- and NGF-induced rapid control of protein synthesis and nociceptive plasticity via convergent signaling to the eIF4F complex. Journal of Neuroscience 30, 15113-15123.
  14. Marina Vardanyan, Ohannes K. Melemedjian, Theodore J. Price, Michael H. Ossipov, Josephine Lai, Edward Roberts, Terrence L. Boos, Jeffrey R. Deschamps, Arthur E. Jacobson, Kenner C. Rice, and Frank Porreca (2010). Reversal of pancreatitis-induced pain by an orally available, small molecule interleukin-6 receptor antagonist. Pain 151, 257-265.
  15. Juan M. Jimenez-Andrade, Monica B. Herrera, Joseph R. Ghilardi, Marina Vardanyan, Ohannes K. Melemedjian, Patrick W. Mantyh. 2008. Vascularization of the dorsal root ganglia and peripheral nerve of the mouse: implications for chemical-induced peripheral sensory neuropathies. Molecular Pain. 4(10)
  16. Tamara King, Anna Vardanyan, Lisa Majuta, Ohannes K. Melemedjian, Raymond Nagle, Anne E. Cress, Todd W. Vanderah, Josephine Lai, Frank Porreca. 2007. Morphine treatment accelerates sarcoma-induced bone pain, bone loss, and spontaneous fracture in a murine model of bone cancer. Pain. 132(1-2):154-68

BOOK CHAPTERS 

  1. Ohannes K. Melemedjian and Arkady Khoutorsky. Translation Control of Chronic Pain. In: Molecular and Cell Biology of Pain, Progress in Molecular and Translational Science.
  2. Theodore J. Price and Ohannes K. Melemedjian. 2012. Fragile X mental retardation protein (FMRP) and the Sensory Spinal System. In: Modeling the Fragile X Syndrome; Results and Problems in Cell Differentiation, 54: 41-59

REVIEWS

  1. Wassim Y. Almawi , Fatima S Al-Shaikh, Ohannes K. Melemedjian, Ahmad W. Almawi. Protein Z: an anti-coagulant protein with expanding role in reproductive biology. Reproduction. 2013 May 20.
  2. Ohannes K. Melemedjian, Theodore J. Price. 2011. Dendritic spine plasticity as an underlying mechanism of neuropathic pain. Experimental Neurology, 233(2):740-744.
  3. Wassim Y. Almawi, Ohannes K. Melemedjian, Maroun M. Jaoude. 2004. On the link between Bcl-2 family proteins and glucocorticoid-induced apoptosis. Journal of Leukocyte Biology, 76(1):7-14.
  4. Wassim Y. Almawi, Ohannes K. Melemedjian. 2002. Negative regulation of nuclear factor-kappaB activation and function by glucocorticoids. Journal of Molecular Endocrinology, 28(2):69-78.
  5. Wassim Y. Almawi, Ohannes K. Melemedjian. 2002. Molecular mechanisms of glucocorticoid antiproliferative effects: antagonism of transcription factor activity by glucocorticoid receptor. Journal of Leukocyte Biology, 71(1):9-15.
  6. Wassim Y. Almawi, Ohannes K. Melemedjian. 2000. Clinical and mechanistic differences between FK506 (tacrolimus) and cyclosporin A. Nephrology, Dialysis, Transplantation, 15(12):1916-1918.
  7. Wassim Y. Almawi, Ohannes K. Melemedjian, Michael J. Rieder. 1999. An alternate mechanism of glucocorticoid anti-proliferative effect: promotion of a Th2 cytokine-secreting profile. Clinical Transplantation, 13(5):365-374.