Luo Z, Health SL, Li M, Yang H, Wu Y, Collins M, Deeks SG, Martin JN, Scott AJ*, Jiang W*. "Variation in blood microbial lipopolysaccharide (LPS) contributes to immune reconstitution in response to suppressive antiretroviral therapy in HIV." EBioMedicine 80: 104037. *co-corresponding authors.

Luo Z, Fitting S, Robinson C, Benitez A, Li M, Wu Y, Fu X, Amato S, Ning W, Funderburg N, Wang X, Zhou Z, Yu X, Wagner A, Cong X, Xu W, Maas K, Wolf B, Huang L, Yu J, Scott AJ, Mcrae-Clark A, Hamlett E, Jiang W. “Chronic cannabis smoking-enriched oral pathobiont drives behavioral changes, macrophage infiltration, and increases β-amyloid protein production in the brain.” 2021 EBioMedicine 74(103701). doi: 10.1016/j.ebiom.2021.103701

Chattagul S^#, Khan MM^#, Scott AJ^#, Nita-Lazar A, Ernst RK, Goodlett DR, Sermswan R. “Transcriptomics analysis uncovers transient ceftazidime tolerance in Burkholderia biofilms.” 2021 Journal of the American Chemical Society 7(8): 2324-2336. doi: 10.1021/acsinfecdis.1c00003
^#co-first author

Cross AS, Opal SM, Palardy JE, Shridhar S, Baliban S, Scott AJ, Chahin AB, Ernst RK. “A Pilot Study of Anti-endotoxin Immunoglobulin-enriched Bovine Colostrum to Prevent Experimental Sepsis.” 2021 Innate Immunity 27(3), 266-274. doi: 10.1177/17534259211007538

Cetuk H, Anishkin A, Scott AJ, Rempe S, Ernst RK, Sukharev S. “Partitioning of seven different classes of antibiotics into LPS monolayers supports three different permeation mechanisms through the outer bacterial membrane.” 2021 Langmuir 37(4), 1372-1385. doi: 10.1021/acs.langmuir.0c02652

Wolter DJ, Scott AJ, Armbruster CR, Whittington D, Edgar JS, Qin X, Buccat AM, McNamara S, Waalkes A, Salipante SJ, Ernst RK, Hoffman LR. “Repeated isolation of an antibiotic-dependent and temperature-sensitive mutant of Pseudomonas aeruginosa from a patient with Cystic Fibrosis.” 2021 J Antimicro. Chemother. 76(3): 616-625. doi: 10.1093/jac/dkaa482

Yang H, Goodlett DR, Ernst RK, Scott AJ. “Mass Spectrometry Imaging of Microbes.” 2020 Mass Spectrometry Letters 11(3), 41-51.

Yang H, Jackson SN, Woods AS, Goodlett DR, Ernst RK*, Scott AJ*. “Streamlined analysis of cardiolipins in prokaryotic and eukaryotic samples using norharmane matrix by MALDI-MSI.” 2020 JASMS 31(12): 2495-2502. doi: 10.1021/jasms.0c00201 *co-senior author

Yang H, Chandler CE, Jackson SN, Woods AS, Goodlett DR, Ernst RK*, Scott AJ*. “On-tissue derivatization of lipopolysaccharides for detection of lipid A using MALDI-MSI.” 2020, Analytical Chemistry. doi: 10.1021/acs.analchem.0c02566 *co-senior author

Spector A, Postolache TT, Akram F, Scott AJ, Wadhawan A, Reynolds MA. “Psychological Stress: Predisposing and triggering factors in periodontal disease.” 2020 Curr Oral Health Rep. In Press. doi: 10.1007/s40496-020-00282-2

Cetuk H, Maramba J, Britt M, Scott AJ, Ernst RK, Mihailescu M, Cotten M, Sukharev S. “Differential interactions of Piscidins with phospholipids and lipopolysaccharides at membrane interfaces.” 2020 Langmuir 36(18): 5065-5077. doi: 10.1021/acs.langmuir.0c00017

Wadhawan A, Reynolds MA, Makkar H, Scott AJ, Potocki E, Hoisington AJ, Brenner LA, Dagdag A, Lowry CA, Dwivedi Y, Postolache TT. “Periodontal pathogens and neuropsychiatric health.” 2020 Curr Topics Medicinal Chemistry 20(15):1353-1397 doi: 10.2174/1568026620666200110161105

Postolache TT, Wadhawan A, Can A, Lowry CA, Woodbury M, Makkar H, Hoisington AJ, Scott AJ, Potocki E, Benros ME, Stiller JW. “Inflammation in traumatic brain injury.” 2020 J Alzheimer’s Disease 74(1): 1-28. doi: 10.3233/JAD-191150

Scott AJ, Chandler CE, Ellis SR, Heeren RMA, Ernst RK. “Maintenance of deep lung architecture and automated airway segmentation for 3D mass spectrometry imaging.” 2019 Scientific Reports 9(20160): 1-12. doi: 10.1038/s41598-019-56364-4

Martin SE, Melander RJ, Brackett CM, Scott AJ, Chandler CE, Nguyen CM, Minrovic BM, Harrill SE, Ernst RK, Manoil C, Melander C. “Small molecule potentiation of Gram-positive selective antibiotics against Acinetobacter baumannii.” 2019 ACS Infectious Disease; 5(7):1223-1230. doi: 10.1021/acsinfecdis.9b00067

Chandler CE, Harberts EM, Laemmermann T, Zeng Q, Opene B, Germain R, Jewell C, *Scott AJ, *Ernst RK. “In vivo intradermal delivery of bacteria using microneedle arrays.” 2018 Infection & Immunity; 86(9):e00406-18. doi: 10.1128/IAI.00406-18 *co-senior author

Scott AJ, Post JM, Lerner R, Ellis SR, Lieberman J, Shirey KA, Heeren RMA, Bindila L, Ernst RK. “Host-based lipid inflammation drives pathogenesis in Francisella infection.” 2017 PNAS 114(47):12596-12601. doi: 10.1073/pnas.1712887114

Scott AJ, Oyler BL, Goodlett DR and Ernst RK. “Lipid A structural modifications in extreme conditions and identification of unique modifying enzymes to define the Toll-like receptor 4 structure-activity relationship.” 2017 BBA Molec Cell Biol Lipids 1862(11): 1439-1450. doi: 10.1016/j.bbalip.2017.01.004

Shaw DK, Wang X, Brown LJ, Chavez AS, Reif KE, Smith AA, Scott AJ, McClure EE, Boradia VM, Hammond HL, Sundberg EJ, Snyder G, Liu L, DePonte K, Villar M, Ueti MW, de la Fuente J, Ernst RK, Pal U, Fikrig E, Pedra JHF. “Infection-derived lipids elicit a novel immune deficiency circuitry in arthropods.” 2017 Nature Comm 14(8):1-13. doi: 10.1038/ncomms14401

Scott AJ, Flinders B, Cappell J, Liang T, Pelc RS, Tran B, Kilgour DPA, Heeren RMA, Goodlett DR, Ernst RK. “Norharmane enhances simultaneous mass spectrometry imaging of pathogen, host, and vector lipids.” 2016 Pathog Dis 74(8): 1-9. doi: 10.1093/femspd/ftw097

Maldarelli GA, Piepenbrink KH, Scott AJ, Freiberg JA, Song Y, Achermann Y, Ernst RK, Shirtliff ME, Sundberg EJ, Donnenberg MS, von Rosenvinge EC. “Type IV pili promote early biofilm formation by Clostridium difficile.” 2016 Pathog Dis 74(8): 1-10. doi: 10.1093/femspd/ftw061

Freiberg JA, LeBreton Y, Tran BQ, Scott AJ, Harro JM, Ernst RK, Goo YA, Goodlett DR, McIver KS, Shirtliff. “Global analysis and comparison of the transcriptome and proteome of Group A Streptococcus biofilms.” 2016 mSystems 1(6): e00149. doi: 10-1128/msystems.00149-16

Scott AJ, Jones JW, MacVittie TJ, Kane MA, Ernst RK. “Biomarker discovery utilizing imaging mass spectrometry to characterize radiation-induced tissue damage.” 2014 HPJ 106(1): 120-128. doi: 10-1097/hp.0b013e3182a4ec2f

Jones JW, Scott AJ, Tudor G, Xu PT, Jackson IL ,Vujaskovic Z, Booth C, MacVittie TJ, Ernst RK, Kane MA. “Identification and quantitation of biomarkers for radiation-induced injury via mass spectrometry platforms.” 2014 HPJ 106(1): 106-119. doi: 10.1097/hp.0b013e3182a4ed3b

Shirey KA, Lai W, Scott AJ, Lipsky M, Mistry P, Pletneva LM, Karp CL, McAlees J, Gioannini TL, Weiss J, Chen WH, Ernst RK, Rossignol DP, Gusovsky F, Blanco JC, Vogel SN. “The TLR4 antagonist, Eritoran, protects mice from lethal influenza infection.” 2013 Nature 497(7450): 498-502. doi: 10-1037/nature12118           

Nchoutmboube JA, Viktorova EG, Scott AJ, Ford LA, Pei Z, Watkins PA, Ernst RK, Belov GA. “Increased long chain acyl-CoA synthetase activity and fatty acid import trigger membrane synthesis for development of picornavirus replication organelles.” 2013 PLOS Pathogens 9(6): e1003401. doi: 10.1371/journal.ppat.1003401

Li Y, Powell DA, Shaffer SA, Rasko DA, Pelletier MR, Leszyk JD, Scott AJ, Masoudi A, Goodlett DR, Wang X, Raetz CR, Ernst RK.  “LPS remodeling is an evolved pathogenic strategy for bacteria.” 2012 PNAS 109(22): 8716-8721. doi: 10.1073/pnas.1202908109

Hoft DF, Blazevic A, Stanley J, Landry B, Sizemore D, Kpamegan E, Gearhart J, Scott AJ, Kik S, Pau MG, Goudsmit J, McClain JB, and Sadoff J. “A recombinant adenovirus expressing immunodominant TB antigens can significantly enhance BCG-induced human immunity.” 2012 Vaccine 30(12): 2098-2108. doi: 10.1016/j.vaccine.2012.01.048

Sharma YV, Cojocaru RI, Ritter LM, Khattree N, Brooks M, Scott AJ, Swaroop A, Goldberg AFX “Protective gene expression changes elicited by an inherited defect in photoreceptor structure.” 2012 PLoS ONE 7(2): e31371. doi: 10.1371/journal.pone.0031371         

Makidon PE, Bielinska AU, Nigavekar SS, Janczak KW, Knowlton J, Scott AJ, Mank N, Cao Z, Rathinavelu S, Beer MR, Wilkinson JE, Blanco LP, Landers JJ, Baker Jr. JR. “Pre-clinical evaluation of a novel nanoemulsion-based Hepatitis B mucosal vaccine.” 2008 PLoS ONE 3(8): e2954. doi: 10.1371/journal.pone.0002954

Chang B, Khanna H, Hawes N, Jimeno D, He S, Lillo C, Parapuram SK, Cheng H, Scott AJ, Hurd RE, Sayer JA, Otto EA, Attanasio M, O’Toole JF, Jin G, Shou C, Hildebrandt F, Williams DS, Heckenlively JR, Swaroop A. “In-frame deletion of a novel centrosomal/ciliary protein Cep290/NPHP6 perturbs its interaction with RPGR and results in early-onset retinal degeneration in the rd16 mouse.” 2006 Human Molecular Genetics 15(11): 1847-1857. doi: 10.1093/hmg/ddl107

 

Chandler CE, Scott AJ, Anderton C, Angel P, Drake R. “IMSS Meeting Report.” 2021 JASMS.

Scott AJ “Establishing a lipid model of host-pathogen interaction using multimodal mass spectrometry imaging in a Francisella infection.” 2015 Dissertation. University of Maryland, Baltimore.

Kilgour DPA, and Scott AJ “Meeting Announcement: MS imaging analysis system for medical applications – MIASMA.” 2015 Rapid Commun. Mass Spectrom. 29: 1185-1186.

 

Valikangas T, Suomi T, Chandler CR, Scott AJ, Tran BQ, Ernst RK, Goodlett DR, Elo LL. “Enhanced longitudinal differential expression detection in proteomics with robust reproducibility optimization regression.” [Submitted, Nature Communications] bioRxiv preprint 2021.04.19.440388

Bocharova O, Fisher A, Pandit NP, Molesworth K, Mychko, Scott AJ, Makarava N, Ritzel R, Baskakov IV. “HSV-1 does not induce Ab pathology in a mouse model of late onset Alzheimer’s disease.” [Submitted, Brain Pathology]

Hyojik Y, Smith R, Chandler CE, Johnson J, Jackson S, Woods A, Scott AJ, Goodlett DR, Ernst RK. “Lipid A structural determination from a single colony.” [In Revision, Analytical Chemistry]

Luo Z, Health SL, Li M, Yang H, Wu Y, Collins M, Deeks SG, Martin JN, Scott AJ*, Jiang W*. “Variation in blood microbial lipopolysaccharide (LPS) contributes to immune reconstitution in response to suppressive antiretroviral therapy in HIV.” [In Revision, EBioMedicine] (*co-corresponding)

Scott AJ, Sherman ME, Chandler CE, Ernst RK. “Harnessing the LPS-TLR4 structure-activity relationship at the interface of gut/brain pathologies.” [Drafting Review, Trends in Micro.]

Virmani A, Pathirage K, Traub RJ, Ernst RK, Scott AJ, Ghodessi R, Abshire P, Babadi B. “Interpretable feature extraction and classification of mass spectrometry imaging data via non-negative matrix factorization.” [Drafting, Journal of the American Society for Mass Spectrometry]

 

2014    “Mass Spectrometry Imaging of Lung Lipids.” January Issue of Health Physics Journal