Glossectomy Study

"Predictors of Speech Quality After Tongue Cancer Surgery"

Funded by NIH grant: R01 - CA133015

Aim 1. Assess the degree to which internal tongue motion explains the relationship between speech quality and surgical procedure.

Develop an atlas of normal motion in 2D and 3D using Tagged MRI Data. Use Principal Components Analysis to compare these patterns to speakers who have had tongue cancer surgery.

Aim 2: Assess the degree to which muscle mechanics explains the relationship between speech quality and surgical procedure.

Track motion of muscles using Diffusion Tensor Imaging to identify muscles and Tagged MRI Data to track them. Compare muscle mechanics of speakers after tongue cancer surgery to control speakers.

Aim 3: Develop a tool to estimate speech improvement from surgical alternatives.

Develop 3D FEM models of the airway for control and patient speakers to determine the effect of airway modifications on speech.

Subjects

Control subjects. patients who have had surgery to remove T1N0M0 or T2N0M0 tumors, with no chemotherapy or radiation therapy.

References:

Principal Components Analysis:

Stone, M, Liu, X, Chen,H, and Prince, JL ( 2010) A preliminary application of principal components and cluster analysis to internal tongue deformation patterns. Computer Methods in Biomechanics and Biomedical Engineering. 13(4), 493-503. Click here to download the paper.

Diffusion Tensor Imaging:

Murano, E., Shinagawa, H, Zhuo, J, Gullapalli, R, Ord, R, Prince J, and Stone, M, (2010) Application of diffusion tensor imaging after glossectomy, Otolaryngology–Head and Neck Surgery, 143, 304-306 Click here to download the paper.

Shinagawa H, Murano EZ, Zhuo J, Landman B, Gullapalli RP, Prince JL, Stone M, (2009) Effect of oral appliances on genioglossus muscle tonicity seen with diffusion tensor imaging: A pilot study. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology. 107: 57-63. Click here to download the paper.

Shinagawa H, Murano EZ, Zhuo J, Landman B, Gullapalli RP, Prince JL, Stone M, (2008) Human tongue muscle fiber tracking during rest and tongue protrusion with oral appliance: A preliminary study with diffusion tensor imaging. Acoust. Sci. & Tech. 29: 291-294.

Stone, M, Liu, X, Shinagawa, S, Murano, EZ, Gullapalli R, Zhuo J, Prince, JL. (2008) Speech patterns in a muscular hydrostat: normal and glossectomy tongue movement. Proceedings of the Fourth B-J-K Symposium on Biomechanics, Healthcare and Information Science., March 13-14, 2008, Kanazawa, Japan.