Selected Peer-Reviewed Publications

Selected Peer-Reviewed Publications
  • Angiopoietin-like 4 induces head and neck squamous cell carcinoma cell migration through the NRP1/ABL1/PXN pathway. Hefni, E, Menon D, Ma T, Asiedu EB, Meiller T, Schneider A, Sultan A, Sodhi A, and Montaner S. Carcinogenesis, 2022, in press. 
  • PAI-1 is a vascular cell-specific HIF-2 dependent angiogenic factor that promotes retinal neovascularization in diabetic patients. Qin Y, Zhang J, Babapoor-Farrokhran S, Applewhite B, Deshpande M, Megarity H, Flores-Bellver M, Aparicio-Domingo S, Ma T, Rui Y, Tzeng SY, Green JJ, Canto-Soler MV, Montaner S, Sodhi A. Sci Adv. 2022 Mar 4;8(9): eabm1896. 
  • Cao X, Sanchez JC, Dinabandhu A, Guo C, Patel TP, Yang Z, Hu MW, Chen L, Wang Y, Malik D, Jee K, Daoud YJ, Handa JT, Zhang H, Qian J, Montaner S, Sodhi A. Aqueous proteins help predict the response of patients with neovascular age-related macular degeneration to anti-VEGF therapy. J Clin Invest. 2022. Jan 18;132(2):e144469. 
  • Zhang J, Qin Y, Martinez M, Flores-Bellver M, Rodrigues M, Dinabandhu A, Cao X, Deshpande M, Qin Y, Aparicio-Domingo S, Rui Y, Tzeng SY, Salman S, Yuan J, Scott AW, Green JJ, Canto-Soler MV, Semenza GL, Montaner S, Sodhi A. HIF-1α and HIF-2α redundantly promote retinal neovascularization in patients with ischemic retinal disease. J Clin Invest. 2021 Jun 15;131(12):e139202. 
  • Sodhi A, Ma T, Menon D, Deshpande M, Jee K, Dinabandhu A, Vancel J, Lu D, Montaner S. Angiopoietin-like 4 binds neuropilins and cooperates with VEGF to induce diabetic macular edema. J. Clin. Invest. 2019. Nov 1;129(11):4593-4608. 
  • Lack of evidence for vasoactive and inflammatory mediators in the promotion of macular edema associated with epiretinal membranes. Applewhite BP, Babapoor-Farrokhran S, Poon D, Hassan SJ, Wellmann E, Ying HS, Semenza GL, Montaner S, Sodhi A. Sci Rep. 2017 6;7(1):10608.  
  • Hypoxia-inducible factor-dependent expression of angiopoietin-Like 4 by conjunctival epithelial cells promotes the angiogenic phenotype of pterygia. Meng Q, Qin Y, Deshpande M, Kashiwabuchi F, Rodrigues M, Lu Q, Ren H, Elisseeff JH, Semenza GL, Montaner S, Sodhi A. Invest Ophthalmol Vis Sci. 2017 58(11):4514-4523.  
  • Expression of the angiogenic mediator, angiopoietin-like 4, in the eyes of patients with proliferative sickle retinopathy. Jee K, Rodrigues M, Kashiwabuchi F, Applewhite BP, Han I, Lutty G, Goldberg MF, Semenza GL, Montaner S, Sodhi A. PLoS One. 2017 12(8):e0183320.  
  • Angiopoietin-like 4 is a potent angiogenic factor and a novel therapeutic target for patients with proliferative diabetic retinopathy. Babapoor-Farrokhran S, Jee K, Puchner B, Hassan SJ, Xin X, Rodrigues M, Kashiwabuchi F, Ma T, Hu K, Deshpande M, Daoud Y, Solomon S, Wenick A, Lutty GA, Semenza GL, Montaner S, Sodhi A. Proc Natl Acad Sci USA. 2015 112(23):E3030-9.   
  • KSHV induces aerobic glycolysis and angiogenesis through HIF-1-dependent upregulation of pyruvate kinase 2 in Kaposi's sarcoma. Ma T, Patel H, Babapoor-Farrokhran S, Franklin R, Semenza GL, Sodhi A, Montaner S. Angiogenesis. 2015 18(4):477-88.   
  • Amplification of the Angiogenic Signal through the Activation of the TSC/mTOR/HIF Axis by the KSHV vGPCR in Kaposi’s Sarcoma. Jham BC, Ma T, Hu J, Chaisuparat R, Friedman ER, Pandolfi PP, Schneider A, Sodhi A and Montaner S. PLoS ONE. 2011 6(4): e19103. 
  • Angiopoietin-like 4: A Novel Molecular Hallmark in Oral Kaposi’s Sarcoma. Hu J, Jham BC, Ma T, Friedman ER, Ferreira L, Wright JM, Accurso B, Allen CM, Basile JR and Montaner S. Oral Oncology. 2011 47(5):371-5.  
  • Viral G protein-coupled receptor up-regulates Angiopoietin-like 4 promoting angiogenesis and vascular permeability in Kaposi’s sarcoma. Ma T, Jham BC, Hu J, Friedman ER, Basile JR, Molinolo A, Sodhi A and Montaner S. Proc Natl Acad Sci USA. 2010 107(32):14363-8.  
  • Dual inhibition of PI3Kα and mTOR as an alternative treatment for Kaposi’s sarcoma. Chaisuparat R, Hu J,Jham BC, Knight ZA, Shokat KM and Montaner S. Cancer Research, 2008 68:8361-8. 
  • A NF-κB gene expression signature contributes to Kaposi’s Sarcoma Virus vGPCR-induced direct and paracrine neoplasia. Martin D, Galisteo R, Ji Y, Montaner S and Gutkind, JS. Oncogene, 2008 27:1844-52. 
  • The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor as a therapeutic target for the treatment of Kaposi's sarcoma. Montaner S, Sodhi A, Ramsdell AK, Martin D, Hu J, Sawai ET, Gutkind JS. Cancer Research, 2006 66, 168-74.  
  • The small GTPase Rac1 Links the Kaposi’s Sarcoma Associated Herpesvirus vGPCR to Cytokine Secretion and Paracrine Neoplasia. Montaner, S., Sodhi, A., Servitja, J.M., Ramsdell, A.K., Barac, A., Sawai, E.T. and Gutkind, J.S. Blood, 2004 104, 2903-2911. 
  • Akt Plays a Central Role in the sarcomagenesis induced by the Kaposi’s sarcoma herpesvirus-encoded G protein-coupled receptor. Sodhi, A., Montaner, S., Patel, V., Gomez-Román, J., Li, Y, Sausville, E.A., Sawai, E.T. and Gutkind, J.S. Proc Natl Acad Sci USA, 2004 101, 4821-4826. 
  • Endothelial infection with KSHV genes in vivo reveals that vGPCR initiates Kaposi's sarcomagenesis and can promote the tumorigenic potential of viral latent genes. Montaner, S., Sodhi, A., Molinolo, A., Bugge, T.H., Sawai, E.T., He, Y., Li, Y., Ray, P.E. and Gutkind, J.S.   Cancer Cell, 2003 3, 23-36.  
  • The Kaposi’s Sarcoma-associated Herpesvirus G Protein-coupled Receptor Promotes Endothelial Cell Survival through the Activation of Akt/Protein kinase B. Montaner, S., Sodhi, A., Pece, S., Mesri, E.A. and Gutkind, J.S. Cancer Research, 2001 61, 2641-2648. 
  • The Kaposi’s Sarcoma Associated Herpesvirus G Protein-Coupled Receptor upregulates VEGF Expression and Secretion through MAPK and p38 Pathways acting on HIF-1α. Sodhi, A., Montaner, S., Patel, V., Zohar, M., Bais, C., Mesri, E.A. and Gutkind, J.S. Cancer Research, 2000 60, 4873-4880.  
  • Activation of the Serum Response Factor by RhoA is mediated by the nuclear factor kB and C/EBP transcription factors. Montaner, S., Perona, R., Saniger, L. and Lacal, J.C. Journal of Biological Chemistry, 1999 274, 8506-8515.  
  • Multiple Signalling Pathways Lead to the Activation of the Nuclear Factor kB by the Rho Family of GTPases. Montaner, S., Perona, R., Saniger, L. and Lacal, J.C. Journal of Biological Chemistry, 1998  273, 12779-12785. 
  • The Small GTP-Binding Protein Rho Links G Protein-Coupled Receptors and Gα12 to the Serum Response Element and to Cellular Transformation. Fromm, C., Coso, O.A., Montaner, S., Xu, N. and Gutkind, J.S. Proc Natl Acad Sci USA, 1997 94, 10098-10103. 
  • Signaling from G Protein-Coupled Receptors to the c-Jun Promoter Involves the MEF2 Transcription Factor: Evidence for a Novel JNK- Independent Pathway. Coso, O.A., Montaner, S., Fromm, C., Lacal, J.C., Prymes, R., Teramoto, H. and Gutkind, J.S. Journal of Biological Chemistry, 1997 272, 20691-20697. 
  • Activation of the Nuclear Factor kB by Rho, Cdc42 and Rac 1 Proteins”. Perona, R.,* Montaner, S.,* Saniger, L., Sanchez-Perez, I., Bravo, R. and Lacal, J.C. Genes & Development, 1997 11,  463-475. * Equal contribution. 
Selected Invited Reviews 
  • Angiopoietin-like 4 as a potential therapeutic target for head and neck squamous cell carcinoma. Montaner, S. Journal of Dentistry and Oral Biology. Special Issue 1-2017. 
  • Molecular mechanisms deployed by virally encoded G protein-coupled receptors in human diseases. Montaner S*, Kufareva I, Abagyan R, Gutkind JS. Annual Review of Pharmacology and Toxicology, 2013 53:331-54.  *Corresponding author. 
  • The Kaposi’s Sarcoma-Associated Herpesvirus G Protein Coupled Receptor: Lessons on Dysregulated Angiogenesis from a Viral Oncogene. Jham, BC and Montaner, S. Journal of Cellular Biochemistry, 2010 110(1):1-9. 
  • Akt/TSC/mTOR activation by the KSHV G protein-coupled receptor: Emerging insights into the molecular oncogenesis and treatment of Kaposi's sarcoma. Montaner, S. Cell Cycle. 2007 6, 438-43. 
  • Viral Hijacking of G-Protein-Coupled-Receptor Signalling Networks. Sodhi, A., Montaner, S.* and Gutkind, J.S.* Nature Reviews, Molecular and Cellular Biology. 2004 5, 998-1012.  *Corresponding author. 
  • Does dysregulated expression of a deregulated viral GPCR trigger Kaposi's sarcomagenesis?. Sodhi, A., Montaner, S. and Gutkind, J.S. FASEB Journal, 2004 18, 422-427.