Research and Scholarship in Operative Dentistry

The Operative faculty are engaged in a variety of basic, translational and educational  research programs.  ​

A main thrust of the research effort is in direct restorative dental materials. Recent efforts are involved in a variety of studies, including quantifying the esthetic characteristics of dental composites, evaluating the effectiveness of dental bonding agents, developing bioactive resin based for use as tooth remineralizing agents, studying techniques for incorporating the scientific method and critical thinking skills in the dental curriculum. 

 

A collection of books and publications in which Operative Dentistry faculty have published

Books

  1. Melo MAS -editor for Developing Bioactive Materials for Restorative Dentistry: A New Look at Current Challenges  published in 2021 by CRC Press Publishing. https://www.taylorfrancis.com/books/e/9780429113284 
  2. Melo MAS, Weir MD, Fakhari, F, Cheng L, Zhang K, Zhou X, Bai Y, Xu HHK. Antibacterial polymers for Dental Adhesives and Composites. Chapter for book entitled: " Adhesion science: Applications in pharmaceutical, biomedical and Dental fields”. Edited by Kasha Mittal and Frank Etzler. Pp 301-323. Wiley –Scrivener Publishing, 2017. ISBN: 978-1-119-32350-1 
  3. Melo MAS, Cheng L, Zhang K, Weir MD, Zhou X, Bai Y, Rodrigues LKA, Xu HHK. Novel nanostructured bioactive restorative materials for dental applications. Chapter for a book entitled: In: Biological and Pharmaceutical Applications of Nanomaterials. Ed. Polina Prokopovich. CRC Press, 2015. P 151-170. 
  4. Xu HHK, Cheng L, Zhang K, Melo MAS, Weir MD, Antonucci JM, Lin NJ, Lin-Gibson S, Chow LC, Zhou X. Nanostructured dental composites and adhesives with antibacterial and remineralizing capabilities for caries inhibition. In: Subramani K., Ahmed W. and Hartfield Jr, JK, Nanobiomaterials in Clinical Dentistry, First Edition, Waltham, Elsevier Publishing, 2013. 

 

Publications

  1. Garcia I., Balhaddad A., Aljuboori Noorhan, Ibrahim M., Mokeem Lamia S, Ogubunka Akudo, Collares F., Melo MA. Wear Behavior and Surface Quality of Dental Bioactive Ions-Releasing Resins Under Simulated Chewing Conditions. Frontiers in Oral Health 2021. DOI:10.3389/froh.2021.628026. 
  2. Hsu K, Balhaddad AA, Garcia IM, Collares FM, DePaola L, Melo MA. Dimensional stability of full arch impressions after disinfection using 3D cone-beam CT image assessment. Saudi Dental Journal. Dec 2020. [Epub ahead of print] 
  3. Balhaddad AA, Marghalani AA, Raderman MA, Miginsky E, Massey W, Strassler H, Anne Melo MA. Hands-on training based on quantifying radiant exposure improves how dental students cure composites: Skill retention at 2-year follow-up. Eur J Dent Educ. 2020 Nov 21. doi: 10.1111/eje.12635. Online ahead of print. 
  4. Melo MA. Bacterial Interactions with Dental and Medical Materials. Editorial:J Funct Biomater. 2020 Nov 23;11(4):83. doi: 10.3390/jfb11040083. 
  5. Rehman IU, Melo MA. Editorial: Molecular Research on Dental Materials and Biomaterials 2018. Int J Mol Sci. 2020 Dec 1;21(23):9154. doi: 10.3390/ijms21239154. 
  6. AlQranei MS, Balhaddad AA, Melo MA. The burden of root caries: Updated perspectives and advances on management strategies. Gerodontology. 2020 Nov 24. doi: 10.1111/ger.12511. Online ahead of print. 
  7. Garcia IM, Balhaddad AA, Ibrahim MS, Weir MD, Xu HHK, Collares FM, Melo MA. Antibacterial response of oral microcosm biofilm to nano-zinc oxide in adhesive resin. Dent Mater. 2021 Mar;37(3):e182-e193. doi: 10.1016/j.dental.2020.11.022. Epub 2020 Dec 17. 
  8. Balhaddad AA, Garcia I, Collares F, Felix CM, Ganesh N, Alkabashi Q, Massei W, Strassler H, Melo MA. Assessment of the radiant emittance of damaged/contaminated dental light-curing tips by spectrophotometric methods. Restor Dent Endod. 2020 Nov 3;45(4):e55. doi: 10.5395/rde.2020.45.e55. eCollection 2020 Nov. 
  9. Passos VF, Sousa RBRA, Melo MA, Gomes EAB, Santiago SL, Lima JPM. In vitro effect of children's toothpaste on brushing abrasion of eroded primary enamel. Eur Arch Paediatr Dent. 2020 May 18. doi: 10.1007/s40368-020-00536-8. Online ahead of print. 
  10. Balhaddad AA, Garcia IM, Ibrahim MS, Collares FM, Xu HH,  Melo MA. Pronounced Effect of Antibacterial Bioactive Dental Composite on Microcosm biofilms derived from Patients with Root Carious Lesions. Front. Mater. | doi: 10.3389/fmats.2020.583861 
  11. AlSahafi R, Balhaddad AA, Mitwalli H, Ibrahim MS, Melo MAS, Oates TW, Xu HHK, Weir MD. Novel Crown Cement Containing Antibacterial Monomer and Calcium Phosphate Nanoparticles. Nanomaterials (Basel). 2020 Oct 11;10(10):2001. doi: 10.3390/nano10102001. 
  12. Balhaddad AA, AlQranei MS, Ibrahim MS, Weir MD, Martinho FC, Xu HHK, Melo MAS. Light Energy Dose and Photosensitizer Concentration Are Determinants of Effective Photo-Killing against Caries-Related Biofilms. Int J Mol Sci. 2020 Oct 15;21(20):7612. doi: 10.3390/ijms21207612. 
  13. Teófilo MÍS, de Carvalho Russi TMAZ, de Barros Silva PG, Balhaddad AA, Melo MAS, Rolim JPML. The Impact of Photosensitizers Selection on Bactericidal Efficacy Of PDT against Cariogenic Biofilms: A Systematic Review and Meta-Analysis. Photodiagnosis Photodyn Ther. 2020 Oct 5:102046. doi: 10.1016/j.pdpdt.2020.102046. Online ahead of print. 
  14. Mitwalli H, Alsahafi R, Balhaddad AA, Weir MD, Xu HH,  Melo MA. Emerging Contact-Killing Antibacterial Strategies for Developing Anti-Biofilm Dental Polymeric Restorative Materials. Bioengineering (Basel) 2020 Jul 30;7(3):83. doi: 10.3390/bioengineering7030083. 
  15. Pontons-Melo JC, Garcia IM, Melo MA, F Collares FM. Aesthetic single-tooth rehabilitation combining root displacement and crown lengthening. Operative Dentistry 2020 Aug [Epub ahead of print] 
  16. Bhadila G, Baras BH, Weir MD, Wang H, Melo MAS, Hack G, Bai Y, Xu HHK. Novel antibacterial calcium phosphate nanocomposite with long-term ion recharge and re-release to inhibit caries. Dent Mater J. 2020 Aug 2;39(4):678-689. doi: 10.4012/dmj.2019-203. Epub 2020 Apr 16. 
  17. Bhadila G, Wang X, Zhou W, Menon D, Melo MAS, Monttaner S, Oates T, Weir M, Sun J, Xu HHK. Novel low-shrinkage-stress nanocomposite with remineralization and antibacterial abilities to protect marginal enamel under biofilm. J Dent 2020 Aug;99:103406. doi: 10.1016/j.jdent.2020.103406. Epub 2020 Jun 8. 
  18. Bhadila G, Filemban H, Wang X, Zhou W, Melo MAS, Atola D, Tay F, Oates T, Weir M, Sun J, Xu HHK. Bioactive low-shrinkage-stress nanocomposite suppresses S. mutans biofilm and preserves tooth dentin hardness. Acta Biomater  2020 Aug 6;S1742-7061(20)30454-2. doi: 10.1016/j.actbio.2020.07.057. Online ahead of print. 
  19. Balhaddad AA, Garcia IM, Ibrahim MS, Rolim PM, Gomes EA, Martinho FC, Collares FM, Xu HH,  Melo MA. Prospects on Nano-Based Platforms for Antimicrobial Photodynamic Therapy Against Oral Biofilms. Photobiomodulation, Photomedicine, and Laser Surgery. 2020 Aug [Epub ahead of print] DOI: 10.1089/photob.2020.4815. 
  20. Bohns FR, Leitune V, Garcia IM, Genari B, Dornelles Júnior NB, Guterres SS, Ogliari F, Melo MA, F Collares FM. Incorporation of amoxicillin-loaded microspheres in mineral trioxide aggregate cement: an in-vitro study. Restorative Dentistry and Endodontics 2020 July [Epub ahead of print] 
  21. F Collares, Garcia IM, Klein M, Parolo C, Sanchez F, Takimi A, Bergmann C, Samuel SM, Melo MA, Leitune V. Exploring needle-like zinc oxide nanostructures for improving dental resin sealers: design and evaluation of antibacterial, physical and chemical properties. Polymer 2020 July [Epub ahead of print] 
  22. Monteiro JC, Sturmer M, Garcia IM, Melo MA, Sauro S, Leitune V, FM Collares. Low viscosity dental resin empowered by 1,3,5-tri acryloyl hexahydro-1,3,5-triazine and α-tricalcium phosphate for anti-caries application Polymers. 2020 Aug  [Epub ahead of print] 
  23. Garcia IM, VCB Leitune, B Genari, NB Dornelles-Júnior, SS Guterres, FA Ogliari, Melo MA. FM Collares. Biointeractive dental resin infiltrant featuring guanidine hydrochloride-induced antibacterial ability against S. mutans. European Polymer Journal. 2020 Aug  [Epub ahead of print] 
  24. Hsu K, Balhaddad AA, Garcia IM, Collares FM, DePaola L, Melo MA. Assessment of surface roughness changes on orthodontic acrylic resin by all-in-one spray disinfectant solutions. Journal of Dental Research, Dental Clinics, Dental Prospects July 2020 [Epub ahead of print] 
  25. Balhaddad AA, Ibrahim MS, Weir MD, Xu HHK, Melo MA. Concentration dependence of quaternary ammonium monomer on the design of high-performance bioactive composite for root caries restorations Dent Mater 2020 Aug;36(8):e266-e278. doi: 10.1016/j.dental.2020.05.009. Epub 2020 Jun 8 
  26. Ibrahim MS, Balhaddad AA, Garcia IM, Collares FM, Weir MD, Xu HHK, Melo MA. Multifunctional antibacterial dental sealants suppress biofilms derived from children at high risk of caries Biomater Sci 2020 Jun 21;8(12):3472-3484. doi: 10.1039/d0bm00370k. Epub 2020 May 20. [Epub ahead of print] 
  27. Ibrahim MS, Balhaddad AA, Garcia IM, Collares FM, Weir MD, Xu HHK, Melo MA. How we are assessing the developing antibacterial resin-based dental materials? A scoping review. J Dent  2020 May 7;103369. doi: 10.1016/j.jdent.2020.103369. Online ahead of print. [Epub ahead of print] 
  28. Ibrahim MS, Balhaddad AA, Garcia IM, Collares FM, Weir MD, Xu HHK, Melo MA.Tooth Sealing Formulation with Bacteria-Killing Surface and On-Demand Ions Release/Recharge Inhibits Early Childhood Caries Key Pathogens Journal of Biomedical Materials Research Part B: Applied Biomaterials 2020 [Epub ahead of print] 
  29. Ibrahim MS, Balhaddad AA, Garcia IM, Collares FM, Weir MD, Xu HHK, Melo MA. pH-responsive Calcium and Phosphate-Ion Releasing antibacterial Sealants on Carious Enamel lesions in vitro. Journal of Dentistry 2020 [Epub ahead of print] 
  30. Garcia IM, Leitune VCB, Ibrahim MS, Melo MA, Faus Matoses V, Sauro S, Collares FM. Determining the Effects of Eugenol on the Bond Strength of Resin-Based Restorative Materials to Dentin: A Meta-Analysis of the Literature. Applied Sciences 2020, 10 (3), 1070 
  31. Khoury Z, Vila T,  Puthran T, Sultan AS, Montelongo-Jauregui, D, Melo MA, Jabra-Rizk MA.The Role of Candida albicans Secreted Polysaccharides in Augmenting Streptococcus mutans Adherence and Mixed Biofilm Formation: In vitro and in vivo Studies. Front. Microbiol., 28 February 2020 | https://doi.org/10.3389/fmicb.2020.00307 
  32. Yao S, Chuanjian Z, Sun J, Weir MD, Melo MA, Tay FR, Lynch C, Imazato S, We J , Xu HHK. Novel antibacterial and therapeutic dental polymeric composites with the capability to self-heal cracks and regain mechanical properties. European Polymer Journal Available online 10 March 2020, 10960 https://doi.org/10.1016/j.eurpolymj.2020.109604 
  33. Garcia IM, Leitune VCB, Takimi AS, Bergmann CP, Samuel SMW, Melo MA, Collares FM. Cerium Dioxide Particles to Tune Radiopacity of Dental Adhesives: Microstructural and Physico-Chemical Evaluation. J Funct Biomater. 2020 Feb 11;11(1):E7. 
  34. Mena Silva PA, Garcia IM, Nunes J, Visioli F, Castelo Branco Leitune V, Melo MA, Collares FM. Myristyltrimethylammonium Bromide (MYTAB) as a Cationic Surface Agent to Inhibit Streptococcus mutans Grown over Dental Resins: An In Vitro Study.J Funct Biomater. 2020 Feb 15;11(1):E9. 
  35. Baras BH, Melo MAS, Thumbigere-Math V, Tay FR, Fouad AF, Oates TW, Weir MD, Cheng L, Xu HHK. Novel Bioactive and Therapeutic Root Canal Sealers with Antibacterial and Remineralization Properties. Materials (Basel). 2020 Mar 1;13(5):E1096. 
  36. Garcia IM, Rodrigues SB, Rodrigues Gama ME, Branco Leitune VC, Melo MA, Collares FM. Guanidine derivative inhibits C. albicans biofilm growth on denture liner without promote loss of materials' resistance. Bioact Mater. 2020 Feb 21;5(2):228-232. 
  37. Fan R, Lee S, Jung H, Melo MA, Masri R. Piezoelectric energy harvester utilizing mandibular deformation to power implantable biosystems: A feasibility study. Journal of Mechanical Science and Technology 33 (8), 4039-4045 
  38. Maktabi H, Ibrahim M, Alkhubaizi Q, Weir M, Xu H, Strassler H, Fugolin APP, Pfeifer CS, Melo MAS. Underperforming light curing procedures trigger detrimental irradiance-dependent biofilm response on incrementally placed dental composites.J Dent. 2019 Sep;88:103110. doi: 10.1016/j.jdent.2019.04.003. Epub 2019 Apr 22. 
  39. Baras BH, Sun J, Melo MAS, Tay FR, Oates TW, Zhang K, Weir MD, Xu HHK. .Novel root canal sealer with dimethylaminohexadecyl methacrylate, nano-silver and nano-calcium phosphate to kill bacteria inside root dentin and increase dentin hardness. Dent Mater. 2019 Oct;35(10):1479-1489. doi: 10.1016/j.dental.2019.07.014. Epub 2019 Aug 3. 
  40. Ibrahim MS, Ibrahim A, Balhaddad AA, Weir MD, Lin NJ, Tay FR, Oates TW, Xu HHK, Melo MA. A Novel Dental Sealant Containing Dimethylaminohexadecyl Methacrylate Suppresses the Cariogenic Pathogenicity of Streptococcus mutans Biofilms. Int J Mol Sci. 2019 Jul 16;20(14). pii: E3491. doi: 10.3390/ijms20143491. 
  41. Souza CL, Rodrigues NS, Aquino EYP, Melo MA; Cunha DA; Saboia VPA. Saliva contamination effects at different application steps on bond strength of total etch two-step adhesive. J. Health Biol Sci. 2019; 7(2):133-138 doi:10.12662/2317-3076jhbs.v7i2.2333.p133-138.2019 
  42. Baras BH, Melo MA, Sun J, Oates TW, Weir MD, Xie X, Bai Y, Xu HHK Novel endodontic sealer with dual strategies of dimethylaminohexadecyl methacrylate and nanoparticles of silver to inhibit root canal biofilms.Dent Mater. 2019 Aug;35(8):1117-1129. doi: 10.1016/j.dental.2019.05.014. Epub 2019 May 23. 
  43. L Cao, J Wu, Q Zhang, B Baras, G Bhadila, Y Li, Melo MA, MD Weir, Bay H, Zhang N, Xu HHK.Novel Protein-Repellent and Antibacterial Resins and Cements to Inhibit Lesions and Protect Teeth. International Journal of Polymer Science 2019 Article ID 5602904 | 11 pages | https://doi-org.proxhs.researchport.umd.edu/10.1155/2019/5602904 
  44. Baras B, Wang S, Melo MA, Tay F, Fouad AA, Arola DD, Weir MD, Xu HK.Novel Bioactive Root Canal Sealer with Antibiofilm and Remineralization Properties. Journal of Dentistry [Epub ahead of print] 
  45. Wu J, Zhou C, Ruan J, Weir MD, Tay F, Sun J, Melo MA, Oates TW, Chang X, Xu HHK. Self-healing adhesive with antibacterial activity in water-aging for 12 months. Dent Mater. 2019 Aug;35(8):1104-1116 
  46. Passos VF, Melo MA, Park J, Strassler HE. Current Concepts and Best Evidence on Strategies to Prevent Dental Erosion. Compend Contin Educ Dent. 2019 Feb;40(2):80-86; quiz 87. 
  47. Balhaddad AA, Kansara AA, Hidan D, Weir MD, Xu HHK, Melo MA. Toward dental caries:Exploring nanoparticle-based platforms and calcium phosphate compounds for dental restorative materials. Bioactive Materials. doi.org/10.1016/j.bioactmat.2018.12.002 
  48. Yi J, Weir MD, Melo MA, Li T, Lynch CD, Oates TW, Dai Q, Zhao Z, Xu HHK. Novel rechargeable nano-CaF2 orthodontic cement with high levels of long-term fluoride release. J Dent. 2019 Nov;90:103214. 
  49. Yi J, Dai Q, Weir MD, Melo MA, Lynch CD, Oates TW, Zhang K, Zhao Z, Xu HHK.A nano-CaF2-containing orthodontic cement with antibacterial and remineralization capabilities to combat enamel white spot lesions.J Dent. 2019 Oct;89:103172. 
  50. Chi M, Qi M, A L, Wang P, Weir MD, Melo MA, Sun X, Dong B, Li C, Wu J, Wang L, Xu HHK. Novel Bioactive and Therapeutic Dental Polymeric Materials to Inhibit Periodontal Pathogens and Biofilms.Int J Mol Sci. 2019 Jan 11;20(2). 
  51. Balhaddad AA, Melo MA, Gregory RL. Inhibition of Nicotine-Induced Streptococcus mutans Biofilm Formation by Salts Solutions Intended for Mouthrinses. Restor Dent Endod. 2019 Jan 16;44(1):e4 
  52. Maktabi H, Balhaddad AA, Alkhubaizi Q, Strassler H, Melo MA. Factors influencing success of radiant exposure in light-curing posterior dental composite in the clinical setting. Am JDent. 2018 Dec;31(6):320-328. 
  53. Ibrahim MS, AlQarni FD, AlDulaijan YA, Weir MD, Xu HHK, Melo MA. Tuning Nano-Amorphous Calcium Phosphate Content in Novel Rechargeable Antibacterial Dental Sealant. Materials (Basel) 2018 Aug 27;11(9):1544. doi: 10.3390/ma11091544. 
  54. Zhang K, Baras B, Lynch CD, Weir MD, Melo MA, Li Y, Reynolds MA, Bai Y, Wang L, Wang S, Xu HHK. Developing a New Generation of Therapeutic Dental Polymers to Inhibit Oral Biofilms and Protect Teeth. Materials (Basel). 2018 Sep 17;11(9). pii: E1747. doi:10.3390/ma11091747. Review. 
  55. Wu J, Xie Xian, Zhou H, Tay F, Weir MD, Melo MA, Oates T, Zhang N, Zhang Q, H. K. Xu.Development of a new class of self-healing and therapeutic dental resins. Polymer Degradation and Stability. [Epub ahead of print] 
  56. Melo MA; Weir MD; Li F.; Cheng L.; Zhang K, Xu HHK. Control of Biofilm at the Tooth-Restoration Bonding Interface: A Question for Antibacterial Monomers? A Critical Review. Rev. Adhesion Adhesives 2017.v.3 (8) p. 287-305. 
  57. Melo MA, Guedes SFF, Xu HHK, Rodrigues LKA. Nanotechnology-based restorative materials for dental caries management. Trends Biotechnol. 2013 Aug; 31(8):459-67. 
  58. Zhang N, Ma Y, Weir M, Xu HHK, Bai Y, Melo MA. Current Insights into the Modulation of Oral Bacterial Degradation of Dental Polymeric Restorative Materials Materials (Basel) 2017 May; 10(5): 507 
  59. Melo MA. Photodynamic antimicrobial chemotherapy as a strategy for dental caries: building a more conservative therapy in restorative dentistry. Photomed Laser Surg. 2014 Nov;32(11):589-91. 
  60. Melo MAS; Silva TPT; Saboia VPA. “Utilização de Pinos Intra-radiculares em reconstrucoes amplas de dentes anteriores” (Use of Intra-radicular posts in the rehabilitation of anterior teeth- review). JBC. Jornal Brasileiro de Clínica Odontológica Integrada e Saúde Bucal Coletiva, v. ed esp, p. 01-10, 2006. (In Portuguese-PT-BR). 
  61. Xiao S, Wang H, Liang K, Tay F, Weir MD, Melo MA, Wang L, Wu Y, Oates TW, Ding Y, Xu HHK. multifunctional nanocomposite for root caries restorations to inhibit periodontitis- related pathogens. J Dent. 2018 Dec 12. pii: S0300-5712(18)30420-2. doi:10.1016/j.jdent.2018.12.001. [Epub ahead of print] 
  62. Xie X, Wang L, Xing D, Qi M, Li X, Sun J, Melo MA, Weir MD, Oates TW, Bai Y, Xu HHK. Novel rechargeable calcium phosphate nanoparticle-filled dental cement. Dent Mater J. 2018 Dec 1. doi: 10.4012/dmj.2017-420. [Epub ahead of print] 
  63. Al-Dulaijan YA, Weir MD, Melo MA, Sun J, Oates TW, Zhang K, Xu HHK. Protein-repellent nanocomposite with rechargeable calcium and phosphate for long-term ion release. Dent Mater. 2018 Dec;34(12):1735-1747. doi: 10.1016/j.dental.2018.09.005. Epub 2018 Sep 27. 
  64. Wang H, Wang S, Cheng L, Jiang Y, Melo MA, Weir MD, Oates TW, Zhou X, Xu HHK. Novel dental  composite  with  the  capability  to  suppress  cariogenic  species and  promote non-cariogenic species in oral biofilms. Mater Sci Eng C Mater Biol Appl. 2019 Jan 1;94:587-596. doi: 10.1016/j.msec.2018.10.004. Epub 2018 Oct 2. 
  65. Park J and Melo MA. “Restoring Multiple Anterior Crown Fractures with Combined Technique using Direct Composite Layering and Glass-Fiber-Post: A Case Report with 5 yrs - Followup”. EC Dental Science 14.6 (2017): 242-248. 
  66. Zhang N, Zhang K, Melo MA, Weir M, Xu DJ, Bai Y, Xu HH. Effects of Long-Term Water- Aging on Novel Anti-Biofilm and Protein-Repellent Dental Composite. Int J Mol Sci. 2017 Jan 18;18(1). 
  67. Kocan J, Weir MD, Melo MA. Investigation of bacterial adhesion on nanoparticle filler - reinforced dental composites after different one-step finishing timing using a Constant-Depth Film Fermenter. Nano Research & Applications 2017 .v3 n.3:11,1-6. 
  68. Chen C, Weir MD; Wang L.; Zhou X.; Xu HHK, Melo MA. Dental Composite FormulationDesign with Bioactivity on Protein Adsorption Combined with Crack-Healing Capability. J. Funct. Biomater. 2017, 8, 40. 
  69. Feng X, Zhang N, Xu HH, Weir M, Melo MA, Bai Y, Zhang K. Novel orthodontic cementcontaining dimethylaminohexadecyl methacrylate with strong antibacterial capability. Dent Mater J. 2017 [Epub ahead of print] 
  70. Cawthon IA and Melo MA. Esthetic Achievement with All-Ceramic Onlay Restorations for Rehabilitation of Compromised Fluorotic Permanent Molars. EC Dental Science 2017;11.5:177-183 
  71. Chang L, Zhang K, Zhang N, Melo MA, Weir M, Bai Y, Xu HH, Reynolds MA. Developing a New Generation of Antimicrobial and Bioactive Dental Resins. Journal of Dental Research.2017 Jul;96(8):855-863. 
  72. Melo MAS, Powers M, Passos VF, Weir MD, Xu HH. Ph-activated nano-amorphous calcium phosphate-based cement to reduce dental enamel demineralization. Artificial Cells, Nanomedicine, and Biotechnology.2017 Dec;45(8):1778-1785. 
  73. Zhang N, Melo MA, Weir M, Reynolds MA, Bai Y, Xu HH. Do Dental Resin Composites Accumulate More Oral Biofilms and Plaque than Amalgam and Glass Ionomer Materials?Materials. 2016 Nov; 9, 888. 
  74. Wang L J, Melo MA, Weir MD, Xie X, Reynolds M, Xu HH. Novel bioactive nanocompositefor Class-V restorations to inhibit periodontitis-related pathogens. Dent Mater. 2016 Dec;32(12):e351-e361 
  75. Melo MAS, Passos VF, Lima JP, Santiago, SL; Rodrigues LKA. Carbohydrate-electrolyte drinks exhibits risks for human enamel surface loss. Restor Dent Endod. 2016 Nov;41(4):246-254. 
  76. Orrego S, Melo MA, Lee SH, Xu HH, Arola DD. Fatigue of human dentin by cyclic loading and during oral biofilm challenge. J Biomed Mater Res B Appl Biomater. 2016 Jun 21. doi:10.1002/jbm.b.33729. [Epub ahead of print] 
  77. Zhang N, Melo MA, Antonucci J, Lin N, Lin-Gibson S, Bai Y, Xu HH. Novel dental cement to combat biofilms and reduce acids for orthodontic applications to avoid enamel demineralization. Materials. 2016, 9(6), 413. 
  78. Zhang N, Weir MD, Chen C, Melo MA, Bai Y, Xu HH. Orthodontic cement with protein- repellent and antibacterial properties and the release of calcium and phosphate ions. J Dent.2016 2016;50:51–59. 
  79. Melo MAS, Souza R, Passos VF, Lima JP, Santiago, SL; Rodrigues LKA. Erosion-preventiveeffect of pediatric fluoridated toothpaste on primary enamel. Int J Clin Pediatr Dent. 2016 9:(4) 1-5. 
  80. de Moraes MD, Melo MA, Bezerra DD, Costa LS, Saboía VP, Rodrigues LK. Clinical study of the caries-preventive effect of resin-modified glass ionomer restorations: aging versus the influence of fluoride dentifrice. J Investig Clin Dent. 2016 May;7(2):180-6. 
  81. Zhang N, Zhang K, Melo MA, Chen C, Fouad AF, Bai Y, Xu HH. Novel protein-repellent andbiofilm-repellent orthodontic cement containing 2-methacryloyloxyethyl phosphoryl choline. J Biomed Mater Res B Appl Biomater. 2016 Jul;104(5):949-59. 
  82. Melo MA, Orrego S, Weir MD, Xu HH, Arola DD. Designing multi-agent dental materials for enhanced resistance to biofilm damage at the bonded interface. ACS Appl Mater Interfaces.2016 11;8(18):11779-87. 
  83. Wu J, Weir MD, Melo MA, Strassler HE, Xu HH. Effects of water-aging on self-healing dental composite containing microcapsules. J Dent. 2016 Apr;47:86-93 
  84. Wu J, Zhou H, Weir MD, Zhang Q, Zhou C. Melo MA, Xu HH. Novel self-healing dental resinwith microcapsules of polymerizable triethylene glycol dimethacrylate and N, N- dihydroxyethyl-p-toluidine. Dent Mater. 2016 Feb;32(2):294-304. 
  85. Melo MA, Rolim JP, Passos VF, Lima RA, Zanin IC, Codes BM, Rocha SS, Rodrigues LK. Photodynamic Antimicrobial Chemotherapy and Ultraconservative Caries Removal Linked for Management of Deep Caries Lesions. Photodiagnosis Photodyn Ther. 2015Dec;12(4):581-6. 
  86. Wu J, Zhou H, Weir MD, Melo MA, Levine ED, Xu HH. Effect of the dimethylaminohexadecyl methacrylate mass fraction on fracture toughness and antibacterial properties of CaP nanocomposite. J Dent. 2015 Dec;43(12):1539-46. 
  87. Zhang N, Melo MA, Chen C, Liu J, Weir MD, Bai Y, Xu HH. Development of a multifunctionaladhesive system for the prevention of root caries and secondary caries. Dent Mater. 2015 Sep;31(9):1119-31. 
  88. Cheng L, Zhang K, Weir MD, Melo MAS, Zhou XD, Xu HHK. Nanotechnology Strategies for Antibacterial and Remineralizing Composites and Adhesives to Tackle Dental Caries. Nanomedicine 2015 Mar;10(4):627-41. 
  89. Zhang N, Chen C, Melo MAS, Bai YX, Zhou XD, Xu HHK. A novel protein-repellent dental composite containing 2-methacryloyloxyethyl phosphorylcholine. International J Oral Sci2015 Jun 26;7(2):103-9. 
  90. Wu J, Weir MD, Melo MA, Xu HH. Development of novel self-healing and antibacterial dental composite containing calcium phosphate nanoparticles. J Dent. 2015 Mar; 43(3):317-26. 
  91. Zhang N, Ma J, Melo MA, Weir MD, Bai Y, Xu HH. Protein-repellent and antibacterial dental composite to inhibit biofilms and caries. J Dent. 2015 Feb; 43(2):225-34. 
  92. Melo MA, Lima JP, Passos VF, Rodrigues LK. The Influence of Dentin Demineralization onMorphological Features of Cavities Using Er: YAG Laser. Photomed Laser Surg. 2015 Jan; 33(1):22-8. 
  93. Melo MAS, Passos VF, Lima JP, Parente GC; Rodrigues LKA; Santiago, SL. Evaluation ofhuman dental enamel after erosive challenge with fresh and processed orange juices. J Dent Child. 2015; 82(1):10-5. 
  94. Melo MA, Codes BM, Passos VF, Lima JPM, Rodrigues LK. In Situ Response of Nanostructured Hybrid Fluoridated Restorative Composites on Enamel Demineralization,Surface Roughness, and Ion Release. Eur J Prosthodont Restor Dent. 2014 Dec; 22 (4):185:190. 
  95. Zhang N, Melo MA, Bai Y, Xu HH. Novel protein-repellent dental adhesive containing 2- methacryloyloxyethyl phosphorylcholine. J Dent. 2014 Oct; 42(10):1284-91. 
  96. Melo MA, Wu J, Weir MD, Xu HH. Novel antibacterial orthodontic cement containing quaternary ammonium monomer dimethylaminododecyl methacrylate. J Dent. 2014 Sep;42(9):1193-201. 
  97. Vasconcelos SM, Melo MA, Wenceslau JP, Zanin IC, Beltrao HC, Fernandes CA, Almeida PC, Rodrigues LK. In situ assessment of effects of the bromide- and fluoride-incorporating adhesive systems on biofilm and secondary caries. J Contemp Dent Pract. 2014 Mar 1; 15(2):142-8. 
  98. Guedes S, Melo MAS, Lima JP, Ely C, Rola AJS, Piva E, Rodrigues LK. Acid etching concentration as a strategy to improve the adhesive performance on Er:YAG laser and bur-prepared demineralized enamel. Photomed Laser Surg. 2014 Jul;32(7):379-85. 
  99. Passos VF, Melo MA, Silva FFC, Rodrigues LK, Santiago SL. Effects of Diode Laser Therapy and Stannous Fluoride on Dentin Resistance under Different Erosive Acid Attacks. Photomed Laser Surg. 2014 2014 Mar; 32(3):146-51. 
  100. Melo MA, Morais WA, Passos VF, Lima JPM, Rodrigues LK. Fluoride releasing and enamel demineralization around orthodontic brackets by fluoride-releasing composite containingnanoparticles. Clin Oral Invest. 2013 May;18(4):1343-50. 
  101. Melo MAS, Weir MD, Rodrigues, LKA. Xu HHK. Novel calcium phosphate nanocomposite with caries-inhibition in a human in situ model”. Dent Mater 2013 Feb; 29(2):231-40. 
  102. Melo, MAS; Zanin ICJ; Lima JPM; Costa EF; Barros EB; Barros EB; Rodrigues LKA. “Characterization of antimicrobial photodynamic therapy-treated Mutans Streptococci by Atomic Force Microscopy (AFM).” Photomed Laser Surg. 2013 Mar; 31(3):105-9. 
  103. Melo MAS, Cheng L, Zhang K, Weir MD, Rodrigues, LKA. Xu HHK. “Novel antibacterialdental adhesive containing silver and amorphous calcium phosphate nanoparticles” Dent Mater 2013 Feb; 29(2):199-210. 
  104. Melo MA, Rolim JP, Zanin IC, Silva JJ, Paschoal AR, Ayala AP, Rodrigues LK. A comparative study of the photosensitizer penetration into artificial caries lesions in dentin measured by theconfocal Raman microscopy. Photochem Photobiol. 2013 Oct 15. doi: 10.1111/php.12186. [Epub ahead of print]. 
  105. Melo MAS, Cheng L, Weir MD, Hsia R, Rodrigues, LKA. Xu HHK. “Novel dental bonding agents containing antibacterial agents and calcium phosphate nanoparticles.” J Biomed Mater Res B Appl Biomater. 2013 May; 101(4):620-9. 
  106. Lima JP, Melo MA, Passos VF, Braga CL, Rodrigues LK, Santiago SL. Dentin erosion by whitening mouthwash associated with tooth brushing abrasion: a focus variation 3D scanningmicroscopy study. Microsc Res Tech. 2013 Sep; 76(9):904-8. 
  107. Melo MA, Silva FFC, Passos VF, Santiago SL, Rodrigues LK. Preventive effect of LED/laser irradiation-activated fluoride on short time dentin erosion. Photon Lasers Med 2013 May-Jun; 2 (3): 209-216. 
  108. Melo MAS, Goes, DC, Moraes, MDR, Santiago, SL. Rodrigues. Effect of Chlorhexidine on the bond strength of a self-etch adhesive system to sound and artificially demineralizeddentin. Braz Oral Res. 2013 May-Jun;27(3):218-24 
  109. Melo MAS; Passos VF; Silva, NRFA; Fernandes CAO. “A case report of 3-year clinical follow-up of Y-TZP-supported crowns fabricated with MAM/MAD technology with slow cooling rate porcelain application”. Am J Esthet Dent. 2013; 3:38–50. 
  110. Passos VF; Melo MAS; Vasconcelos AA; Bodstein HSM; Rodrigues LKA; Santiago, SL. “Comparison of measurement methods in the quantification of surface loss and softening by erosion and erosion/abrasion of enamel and dentin”. Microsc Res Tech. 2013 Feb; 76(2):178-83. 
  111. Borges FM, Melo MAS, Lima JP, Zanin IC, Rodrigues LK. “Antimicrobial effect of chlorhexidine digluconate in dentin: In vitro and in situ study”. J Conserv Dent. 2012 Jan;15(1):22-6. 
  112. Cheng L, Zhang K, Melo MAS, Weir MD, Zhou X, Xu HHK. “Anti-biofilm dentin primer with quaternary ammonium and silver nanoparticles”. J Dent Res. 2012 Jun; 91(6):598-604. 
  113. Zhang K, Melo MAS, Cheng L, Weir MD, Bai Y, Xu HHK. “Effect of quaternary ammonium and silver nanoparticle-containing adhesives on dentin bond strength and dental plaquemicrocosm biofilms”. Dent Mater. 2012 Aug; 28(8):842-52. 
  114. Rolim JP, Melo MAS, Guedes SF, Albuquerque-Filho FB, de Souza JR, Nogueira NA, Zanin IC, Rodrigues LK. “The antimicrobial activity of photodynamic therapy against Streptococcus Mutans using different photosensitizers”. J Photochem Photobiol B. 2012 Jan 5; 106:40-6. 
  115. Melo, MAS, Passos VF, Apolonio FB, Rego RO, Santiago SL, Rodrigues LKA. “Restoring esthetics in eroded anterior teeth: a conservative multidisciplinary approach”; Gen Dent 2011;59(1):48-52. 
  116. Melo MAS, Passos VF, Alves JJ, Barros EB, Santiago SL, Rodrigues LKA. “The effect ofdiode laser irradiation on dentin as a preventive measure against dental erosion: an in vitro study”. Lasers Med Sci. 2011 Sep; 26(5):615-21. 
  117. Monteiro-Oliveira MA, Rodrigues LKA, Melo MAS, Nobre-dos-Santos M. “Photodynamic Therapy Effect in Carious Bovine Dentin – An In Vitro Study”. J Oral Laser Appl 2010; 10: 29-36. 
  118. Melo, MAS; De-paula, D M; Lima JPM; Borges FMC; Steiner-oliveira C; Nobre-dos-santosM; Zanin ICJ; Barros EB; Rodrigues LKA. “In vitro photodynamic antimicrobial chemotherapy in dentine contaminated by cariogenic bacteria”. Laser Phys 2010, v. 20, p.1-10. 
  119. De-paula DM, Melo MAS, Lima JPM, Nobre-dos-santos M., Zanin ICJ, Rodrigues LKA. “In vitro assessment of thermal changes in human teeth during photodynamic antimicrobia chemotherapy performed with red light sources”. Laser Phys. v. 20, n. 6, pp. 1–6, 2010. 
  120. Borges, FMC; Melo, MAS; Lima, JPM.; Zanin, ICJ; Rodrigues ,LKA ; Nobre-dos-santos M. “Evaluation of the effect of photodynamic antimicrobial therapy in dentin caries: a pilot in vivostudy”. In: 2010 SPIE. (Org.). SPIE Proceedings, v. 7549, p. 75490, 2010. 
  121. Sousa RP, Zanin IC, Lima JP, Vasconcelos SM, Melo MAS, Beltrão HC, Rodrigues LKA. “Insitu effects of restorative materials on dental biofilm and enamel demineralization”. J Dent. 2009 Jan;37(1):44-51 
  122. Lima, JPM; Melo, MAS; Borges, FMC; Teixeira, AH; Steiner-oliveira, C; Nobre dos santos,M; Rodrigues, LKA; Zanin, IC. J. “Evaluation of the antimicrobial effect of photodynamic antimicrobial therapy in a model of dentine caries”. Eur J Oral Sci 2009, v. 117, p. 568-574. 
  123. Lima, JPM; Melo, MAS; Borges, FMC; Teixeira, AH; Steiner-oliveira, C; Nobre dos santos,M; Rodrigues, LKA; Zanin, IC IC, Rodrigues LK. “The antimicrobial activity of photodynamic therapy against Streptococcus Mutans using different photosensitizers”. J Photochem Photobiol B. 2012 Jan 5; 106:40-6. 
  124. Melo, MAS, Passos VF, Apolonio FB, Rego RO, Santiago SL, Rodrigues LKA. “Restoring esthetics in eroded anterior teeth: a conservative multidisciplinary approach”; Gen Dent 2011;59(1):48-52. 
  125. Melo MAS, Passos VF, Alves JJ, Barros EB, Santiago SL, Rodrigues LKA. “The effect ofdiode laser irradiation on dentin as a preventive measure against dental erosion: an in vitro study”. Lasers Med Sci. 2011 Sep; 26(5):615-21. 
  126. Monteiro-Oliveira MA, Rodrigues LKA, Melo MAS, Nobre-dos-Santos M. “Photodynamic Therapy Effect in Carious Bovine Dentin – An In Vitro Study”. J Oral Laser Appl 2010; 10: 29-36. 
  127. Melo, MAS; De-paula, D M; Lima JPM; Borges FMC; Steiner-oliveira C; Nobre-dos-santosM; Zanin ICJ; Barros EB; Rodrigues LKA. “In vitro photodynamic antimicrobial chemotherapy in dentine contaminated by cariogenic bacteria”. Laser Phys 2010, v. 20, p.1-10. 
  128. De-paula DM, Melo MAS, Lima JPM, Nobre-dos-santos M., Zanin ICJ, Rodrigues LKA. “In vitro assessment of thermal changes in human teeth during photodynamic antimicrobia chemotherapy performed with red light sources”. Laser Phys. v. 20, n. 6, pp. 1–6, 2010. 
  129. Borges, FMC; Melo, MAS; Lima, JPM.; Zanin, ICJ; Rodrigues ,LKA ; Nobre-dos-santos M. “Evaluation of the effect of photodynamic antimicrobial therapy in dentin caries: a pilot in vivostudy”. In: 2010 SPIE. (Org.). SPIE Proceedings, v. 7549, p. 75490, 2010. 
  130. Sousa RP, Zanin IC, Lima JP, Vasconcelos SM, Melo MAS, Beltrão HC, Rodrigues LKA. “Insitu effects of restorative materials on dental biofilm and enamel demineralization”. J Dent. 2009 Jan;37(1):44-51 
  131. Lima, JPM; Melo, MAS; Borges, FMC; Teixeira, AH; Steiner-oliveira, C; Nobre dos santos,M; Rodrigues, LKA; Zanin, IC. J. “Evaluation of the antimicrobial effect of photodynamic antimicrobial therapy in a model of dentine caries”. Eur J Oral Sci 2009, v. 117, p. 568-574. 
  132. Melo MAS; Silva TPT; Saboia VPA. “Colagem de Fragmento Autógeno em Dentes Posteriores como uma Abordagem Conservadora - Relato de Caso”. (Homogenous dental bonding of dental fragment in a permanent posterior tooth - a clinical case report). JBC. Jornal Brasileiro de Clínica Odontológica Integrada e Saúde Bucal Coletiva, v. ed esp, p. v. 01, p.01, 2006. (In Portuguese). 
  133. Freire filho FWV; Freire EF; Melo MAS; Pinheiro D P; Cauby AF. “Angina de Ludwig: relato de caso” (Ludwig angina: case report). Revista Brasileira de Cirurgia e Periodontia, v. 1, p.190-196, 2003 (In Portuguese).