Endodontics, Prosthodontics and Operative Dentistry

Grants

1.      National Institute of Dental and Craniofacial Research

(2009–2014)(NIH R01 DE14190). “Injectable and Strong Nano-Apatite/Stem Cell Scaffolds for
Bone Regeneration.. PI:  Huakun Xu.

(2008 -2012)(NIH R01 DE17974). “Development of High Performance, Caries-Inhibiting
Dental Nano-Materials.. PI:  Huakun Xu.

(2005-2010)(R01-DE015320-01A1) Primary and Therapy-Resistant
Endodontic Infections. P.I. A. Fouad.  

(2003 -2009)(NIH R01 DE14190). “Development of Strong and Macroporous
Biomaterials.  PI: Huakun Xu.

2.     Maryland Stem Cell Research Commission

(2008 –2010). "Stem Cell Delivery via Injectable, Nano-Apatite Scaffolds for Bone Engineering. PI: Huakun Xu.  

3.     American Association of Endodontists Foundation

(2008-2010): The effects of bisphosphonate treatment on the prevalence and pathogenesis of endodontic
pathosis.  P.I. A. Fouad on Grant submitted by postgraduate student Felicity Shelton.

(2008-2009): The Effect of Endodontic Instrumentation Techniques on Post-Operative Local and  
Systemic Responses. P.I. A. Fouad on Grant submitted by postgraduate student Yelena Kholodenko.

(2008-2009): Comparison of Bupivacaine vs. Lidocaine on Pain and Inflammatory Regulation Following
Endodontic Surgery: a Double-Blind, Randomized, Controlled Clinical Trial. P.I. A. Fouad on Grant
submitted by postgraduate student Anastasia Mischenko and faculty member Sharon Gordon.

(2008-2010): Penetration of systemic antibiotics into necrotic pulp space. P.I. A. Fouad on
Grant submitted by postgraduate student Maheeb Jaouni.

(2007-2009): The relationship between chronic endodontic infection and the progression of
systemic disease in a mouse model. P.I. A. Fouad on Grant submitted by postgraduate
student Jessica Russo.

Published Manuscripts

Kakoli P., Nandakumar R., Romberg E., Arola D., Fouad A.F. The effect of age on bacterial
penetration of radicular dentin. J Endod 2009:35(1):78-81.

Nandakumar R, Madayiputhia N, Fouad AF. Proteomic Analysis of Endodontic Infections by
Liquid Chromatography -Tandem Mass Spectrometry. Oral Microbiol Immunol 2009 (in press).

Limkangwalmongkol P, Kee E, Chiche GJ, Blatz MB. Comparison of Marginal Fit between All-Porcelain Margin vs Alumina-Supported Margin on Procera Alumina Crowns. J Prosthodont. 2009.Feb;18(2):162-6.

Masri R, Quiton RL, Lucas JM, Murray PD, Thompson SM, Keller A. Zona Incerta: A
Certain Role in Central Pain. J Neurophys. 2009 In press.

Evtimosvska B, Masri R, Driscoll CF, Romberg E. The Change in Retentive Values of Locator
Attachments and Hader Clips Over Time. J Prostho. 2009 (In press).

Moreau JL, Xu HHK. Mesenchymal stem cell proliferation and differentiation on an injectable
calcium phosphate-chitosan composite scaffold. Biomaterials 2009;30:2675-2682.

Tan KM, Singer MT, Masri R, Driscoll CF. Modified fluid wax impression for a severely
resorbed edentulous mandibular ridge. J Prosthet Dent. 2009; 101:279-82

Moreau JL, Weir MD, Xu HHK. Self-setting collagen-calcium phosphate bone cement:
Mechanical and cellular properties. J Biomed Mater Res A (2009, in press

Weir MD, Xu HHK.  Osteoblastic induction on calcium phosphate cement-chitosan constructs
for bone tissue.  J Biomed Mater Res A (2009, in press).

Xu HHK, Weir MD, Sun S, Moreau JL, Takagi S, Chow LC, Antonucci JM. Strong Nanocomposites
with Ca, PO₄ and F Release for Caries Inhibition. J Dent Res (Invited review paper. 2009, (in press)

Weir MD, Xu HHK. High-strength, in situ-setting calcium phosphate composite with protein
release. J Biomed Mater Res 2008;85A:388-396.

Xu HHK, Weir MD, Simon CG. Injectable and strong nano-apatite scaffolds for cell/growth
factor delivery and bone regeneration. Dental Materials 2008;24:1212-1222.

Xu HHK, Weir MD, Sun L.  Calcium and phosphate ion releasing composite: Effect of pH on
release and mechanical properties.  Dent Mater 2009;25:535-542.

Burguera EF, Xu HHK, Sun L. Injectable calcium phosphate cement: Effects of powder-to-liquid
ratio and needle size. J Biomed Mater Res 2008;84B:493-502.

Textbooks and Textbook Chapters

Fouad AF (Editor). Endodontic Microbiology, Wiley-Blackwell Publishing, April, 2009.

Fouad AF. Endodontic Infections and Systemic Disease Chapter 16, in Endodontic Microbiology,
Fouad AF Editor, Wiley-Blackwell Publishing, 2009.

Fouad AF. Molecular Mediators of Pulpal Inflammation, Chapter 11 in: The Dental Pulp, Hargreaves
K and Goodis H, Editors, 2nd Edition, Quintessence Int., (in press).

Fouad AF. Levin L. Pulpal Reactions to Caries and Dental Procedures, Chapter 13 in: Pathways of the
Pulp, Tenth Edition; Cohen S and Hargreaves K, Editors, Mosby, (in press).

Patents

Keller, A., Masri, R., Quiton R., Methods for treating central pain syndrome and other pain related
pathologies. Provisional patent. Febuary 11,2009. Docket number: AK-2009-044.

Abstracts

Nazari A, Bajaj D, Ivancik J, Zhang D, Romberg E and Arola D. On the reduction in toughness of
human dentin with patient age. J Dent Res 87 (Spec Iss A):#2103, also presented at the 87th
General Session and Exhibition of the IADR, Miami FL, April 1-4, 2009.

Ryou H, Amin N, Romberg E, Wang D, Eidelman N, and Arola D. Flaw sensitivity of dentin: Importance
of depth and microstructure. J Dent Res 87 (Spec Iss A):0090, alsopresented at the 87th General
Session and Exhibition of the IADR, Miami FL April 1-4, 2009.

Arvidson Bufano UB, Gilliam J, Park SH, Romberg E. Multimedia Learning Tool to Teach Standardized
Gathering and Recording of Clinical Data in the Predoctoral Clinic. J Dent Educ 2009: 249, ADEA
Abstract #52

Orgel A, Chand P, Hicks ML, Nandakumar R, Barbuto S, Paster BJ, Fouad AF. Effects of residual
microbial presence and diversity on endodontic outcomes. J Dent Res 2008. IADR Special issue.
Abstract #953.

Fouad AF. Characterization of Microbial Content of the Diseased Dental Pulp Perioperatively. Pulp
Biology and Regeneration Symposium. J Dent Res 2009. Special issue. IADR Abstract #129.

Li L, Hsiao WWL, Nandakumar R, Barbuto S, Mongodin EF, Paster BJ, Fraser-Liggett CM, Fouad AF.
Operational Taxonomic Unit analysis of bacterial communities in endodontic infections. J Dent Res
2009. IADR Special issue. Abstract #196.

Li L, Hsiao WWL, Nandakumar R, Barbuto S, Mongodin EF, Paster BJ, Fraser-Liggett CM, Fouad AF.
New Bacterial diversity in primary endodontic infection revealed by high-throughput deep coverage
pyrosequencing technology. J Endod 2009: 35 (3): 436.

Bennett IG, Nandakumar R, Paster BJ, Barbuto S, Fouad AF. Microbial Changes in Endodontic
Infections Following Treatment Procedures. J Endod 2009: 35 (3): 444.

Alongi DJ, Fouad AF, Huang GT. Effect of inflammation on pulp stem cell potency. J Endod
2009: 35 (3): 428.

Mischenko AV, Letwin N, Wills K, Fouad AF, Gordon SM. Bupivacaine Increases PGE2 Expression
In-Vitro. J Endod 2009: 35 (3): 451.

Levine ED, Xu HHK, Moreau JL, Strassler HE.  Dental nanocomposites: mechanical properties
in long-term water-aging.  IADR Annual Meeting, Miami, April 2009.

Mays KA, Palmer JB, Kuhlemeier KV. Craniofacial Morphology and Hyoid Movement: A Correlational
Study. Dysphagia, 2009, 24:71-76.

Moreau JL, Weir MD, Xu HHK. Self-setting collagen-calcium phosphate bone cement: Mechanical and
cellular properties. J Biomed Mater Res A (2009, accepted for publication).

Moreau JL, Xu HHK.  Mesenchymal Stem Cell Proliferation and Differentiation on Self-Setting Nano-Apatitic
Scaffolds.  IADR Annual Meeting, Miami, FL, April 2009.

Moreau JL, Weir MD, Xu HHK.  Self-setting Collagen-Calcium Phosphate Bone Cement: Mechanical and Cellular
Properties.  IADR Annual Meeting, Toronto, Canada, July 2008.

Weir MD, Xu HHK. Osteoblastic induction on calcium phosphate cement-chitosan constructs for bone tissue. 
J Biomed Mater Res A (2009, in ).

Weir MD, Betz MW, Fisher JP, Xu HHK.  Mesenchymal stem cell interactions with nanoapatite scaffolds
for bone repair.  IADR Annual Meeting, Miami, FL, April 2009.

Xu HHK, Weir MD, Sun L.  Calcium-Phosphate Resin Composite: pH Effects on Ion-Release and
Mechanical Properties.  IADR Annual Meeting, Miami, FL, April 2009.

Xu HHK, Weir MD, Sun S, Ngai S, Takagi S, Chow LC.  Effect of filler level and particle size on
dental caries-inhibiting Ca-PO4 composite.  J Mater Science: Mater in Medicine (2009, accepted
for publication).

Xu HHK, Moreau JL, Yen JH, Guthrie WF. Photo-cured dental composite with calcium and
phosphate ion release for caries inhibition. J Biomed Mater Res B (2009, in review).

Arola D, Bajaj D and Zhang D. Evaluations on the crack growth resistance of enamel and the
dentin enamel junction. Presented at the 1st Annual Conference on Experimental Mechanics in
Biomedical Research, Shanghai University, Shanghai China, Dec. 20-21, 2008.

Bajaj D, Nazari A, Eidelman N, and Arola D. A comparison of fatigue crack growth in human
enamel and hydroxyapatite. Biomaterials 2008; 29(36):4847-4854.

Zhang D, Lu C, Zhang X, Han Y and Arola D. Contact fracture of full ceramic crowns subjected
to occlusal loads. Journal of Biomechanics 2008; 41(14):2995-3001.

Chiaraput S, Mai S, Huffman BP, Kapur R, Agee KA, Yiu CKY, Chan DCN, Harnirattisa C,
Arola D, Rueggeberg FA, Pashley DH, and Tay FR. Changes in resin-infiltrated dentin
stiffness after water storage. Journal of Dental Research 2008; 87(7):655-660.

Park S, Quinn JB, Romberg E and Arola D. On the brittleness of enamel and selected dental
materials. Dental Materials 2008; 24(11): 1477-1485.

Yeager C, Nazari A and Arola D. Machining of cortical bone: Surface texture, surface integrity
and cutting forces. Machining Science and Technology 2008; 12(1):100-118.

Park S, Wang DH, Zhang D, Romberg E and Arola D. Mechanical properties of human enamel
as a function of age and position in the tooth. Journal of Materials Science: Materials in Medicine
2008; 19(6):2317-2324.

Wood JD, Sobolewski P, Brougher JA, Thakur V, Arola D, Tay FR, Pashley DH. Measurement
of micro-strain across resin-dentin interfaces using microscopic moire interferometry. Dental
Materials 2008; 24(7):859-866.

Nandakumar R, Tofigh M, Paster  BJ, Barbuto S., Fouad AF. Diversity and Sources of Enterococcus
Spp in Endodontic Infections. J Dent Res 2008. Special issue. AADR Abstract #751.

Fouad AF, Paster BJ, Nandakumar R, Barbuto S. Microbial diversity in primary and therapy-resistant
endodontic infections. J Dent Res 2008. Special issue. IADR Abstract #1525.

Nandakumar R, Madayiputhiya N, Fouad AF. Proteomic analysis of endodontic infections by liquid
|chromatography-tandem mass spectroscopy. ICAAC/IDSA Joint Meeting of ASM and IDSA, 2008.
Abstract #B-3810, 304(B), 80.

Weir MD, Hom JM, Xu HHK. Characterization of Cell Differentiation on CPC for Bone Tissue
Engineering.  IADR Annual Meeting, Toronto, Canada, July 2008.

Weir MD, Xu HHK. Mesenchymal Stem Cell Delivery via Nanoapatite Scaffolds for Bone
Repair.  Maryland Stem Cell Symposium, December 2008.

Xu HHK. Development of novel dental nanocomposites.  Dentsply, Milford, DE, October, 2008,
Invited Talk.

Xu HHK, Weir MD, Sun S, Moreau JL, Takagi S, Chow LC, Antonucci JM.  Strong Nanocomposites
with Ca, PO4 and F Release for Caries Inhibition.  J Dent Res (Invited review paper.
Accepted for publication).

Xu HHK. Symposium Organizer.  Glass-ionomer Cements – Current and Future Performance. 
IADR Annual Meeting, Toronto, Canada, July 2008.

Xu HHK. Symposium Organizer.  Zirconia-based restorations: Successes, failures and clinical
recommendations.  IADR Annual Meeting, Toronto, Canada, July 2008.