Endodontics, Prosthodontics and Operative Dentistry

Grants

 National Institute of Dental and Craniofacial Research
 (R01-DE015320-01A1):
P.I.: Primary and Therapy-Resistant Endodontic Infections, Fouad, A.   

R01 DE17974.  PI:  Huakun Xu.
Development of High Performance, Caries-Inhibiting Dental Nano-Materials.
Maryland Nano-Biotech Award, , 09/04/2007 – 06/30/2008., Xu, HHK

(2007 -2011) Aging and Fatigue Crack Growth in Dentin, Arola, D

Maryland Stem Cell Research Commission. 

PI:  Huakun Xu
07/01/2008 – 06/31/2010
"Stem Cell Delivery via Injectable, Nano-Apatite Scaffolds for BoneEngineering."

American Association of Endodontists Foundation

Effect of inflammation on pulp stem cell potency (2007-2009). Submitted by graduate student Dominick Alongi ,Mentor: George T.-J. Huang

Identification of Antibiotic Resistance Genes in Primary and Persistent Endodontic Infections.  P.I. on Grant submitted by postgraduate student Dr. G. Dalrymple, Mentor: A. Fouad

The relationship between chronic endodontic infection and the progression of systemic disease in a mouse model. P.I. on Grant submitted by postgraduate student Dr. Jessica Russo, Mentor: A. Fouad            

The Effect of Endodontic Instrumentation Techniques on Post-Operative Local and Systemic Responses P.I. on Grant submitted by postgraduate student Dr. Yelena Kholodenko,Mentor: A. Fouad

Comparison of Bupivacaine vs. Lidocaine on Pain and Inflammatory Regulation Following Endodontic Surgery: a Double-Blind, Randomized, Controlled Clinical Trial  P.I. on Grant submitted by postgraduate student Dr. Anastasia Mischenko (mentor: Dr. Sharon Gordon)

The effects of bisphosphonate treatment on the prevalence and pathogenesis of endodontic pathosis. P.I. on Grant submitted by postgraduate student Dr. Felicity Shelton, Mentor: A. Fouad

Penetration of systemic antibiotics into necrotic pulp space. P.I. on Grant submitted by postgraduate student Dr. MaheebJaouni, Mentor: A. Fouad                                                                                                     

American College of Prosthodontics Education Fund

2007-2008     Co- investigator, “The Effect of Denture Cleansing Solutions on the Retention of Metal Clips”. Driscoll, C.

2007-2008     Caroline Nguyen, “The Effect of Denture Cleansing Solutions on the Retention of Pink Locator Abutments”

Greater New York Academy of Prosthodontics

2007-2008      Co- investigator, “Effect of Lubricants on the Retention of Cast Post and Cores”.  Driscoll, C

Imaging Science International
2007 Clinical validation of cone beam CT for Periodontal Diagnosis., Co-Investigator, Armellini, D.

American Academy of Esthetic Dentistry

2007 Effect of Surface Glazing Sealants on Color Stability of Composite Resins, Sensi, LG

Published Manuscripts

Warren CA, Mok L, Gordon S, Fouad AF, Gold MS. Quantification of Neural Protein in Extirpated Tooth Pulp. J Endod 2008 Jan; 34(1):7-10.

Nandakumar R, Whiting J, Fouad AF. Identification of selected respiratory pathogens in endodontic infections. Oral Surg Oral Med Oral Pathol Oral Radiol Endod (in press)

Sarlani E, Garrett PH, Grace EG, Greenspan JD. Temporal summation of pain characterizes women but not men with temporomandibular disorders. Journal of Orofacial Pain. 2007(4)309-17.

Flores MT, Andersson L, Andreasen JO, Bakland LK, Malmgren B,  Barnett F, Bourguignon C, DiAngelis A, Hicks ML, et al. Guidelines for the management of traumatic dental injuries. I. Fractures and luxations of permanent teeth. Dent Traumatol 2007;23:66-71.

Flores MT, Andersson L, Andreasen JO, Bakland LK, Barnett F, Bourguignon C, DiAngelis A,   Hicks ML, et al. Guidelines for the management of traumatic dental injuries. II. Avulsion of permanent teeth. Dent Traumatol 2007;23:130-6.

Flores MT, Malmgren B, Andersson L, Andreasen JO, Bakland LK, Barnett F, Bourguignon C,DiAngelis A, Hicks ML, et al. Guidelines for the management of traumatic dental injuries. III. Primary teeth. Dent Traumatol 2007;23:196-202.

Sonoyama W, Liu Y, Yamaza T, Tuan RS, Wang S, Shi S, Huang GT. Characterization of the apical papilla and its residing stem cells from human immature permanent teeth: a pilot study. J Endod. 2008 Feb;34(2):166-71.(Cover page)

Huang GT, Lee HW, Lee HS, Lee GH, Huh SY, Choi GW, Park SH. Localization of substance P-induced upregulated interleukin-8 expression in human dental pulp explants.Int Endod J. 2008 Feb;41(2):100-7. Epub 2007 Nov 12

Limkangwalmongkol P, Chiche GJ, Blatz MB. Precision of fit of two margin designs for metal-ceramic crowns. J Prosthodontics 2007. Jul-Aug;16(4):233-7.

Limkangwalmongkol P, Kee E, Chiche GJ, Blatz MB. Comparison of Marginal Fit between All-Porcelain Margin VS Alumina Supported Margin on Procera Alumina Crowns. In Press, Accepted for publication in the Journal of Prosthodontics on February 4, 2008.

Koichiro Matsuo, Hiromichi Metani, Keith A. Mays, Jeffrey B. Palmer. Tempospatial Linkage of soft palate and jaw movements in feeding. Journal of Japanese Dysphagia Rehabilitation (in press) 

Jham BC, Duraes GV, Strassler HE, Sensi LG. Joining the podcast revolution. J Dent Educ. 2008 Mar;72(3): 278-81.

Marson FC, Sensi LG, Vieira LC, Araújo E. Clinical evaluation of in-office dental bleaching treatments with and without the use of light-activation sources. Oper Dent. 2008 Jan-Feb;33(1): 15-22.

Strassler HE, Sensi LG. Contemporary dental adhesives for direct placement composite resins. www.ineedce.com. 2008; 1-13.

Strassler HE, Sensi LG. Etch-and-rinse adhesive bonding. Functional Esthetics & Restorative Dentistry. 2008;2(1): 44-49.

Marson FC, Sensi LG, Arruda T. Effect of bleaching on the enamel shear bond strength (in Portuguese). RGO. 2008 56(1): 33-37.

Sensi LG, Webley W. A simplified approach for layering composite resin restorations. Gen Dentistry. 2007 Nov;55(7): 638-45.

Strassler HE, Sensi LG. Contemporary dental cements to meet the challenges of today’s restorative dentistry. Functional Esthetics & Restorative Dentistry. 2007;1(3): 44-49.

Marson FC, Sensi LG. Aesthetic excellence in anterior restorations with composite resins (in Portuguese). Scient A. 2007 1(2): 45-54.

Marson FC, Sensi LG, Vieira LCC, Baratieri LN. Effect of a sodium ascorbate gel on the bond strength between bleached enamel and composite resin (in Portuguese). R Odont Unesp. 2007 36(1).

Marson FC, Sensi LG. In-office vital tooth bleaching and the need to use auxiliary lights (in Portuguese). R Dental Press Estét. 2007 4(3): 41-53.

Sensi LG. Reproduction of natural optical effects with composite resins. Mdental. 2007 Fall;1-12.

Strassler HE. Minimally invasive porcelain veneers: indications for a conservative esthetic dentistry treatment modality.  Gen Dent. 2007; 55(7): 686-96

Strassler HE, Serio CL.  Esthetic considerations when splinting with fiber-reinforced composites.  Dent Clin North Am. 2007; 51(2):507-24.

Karbhari VM, Strassler H.  Effect of fiber architecture on flexural characteristics and fracture of fiber reinforced dental composites.  Dent Mater. 2007; 23(8):960-8.

Burguera EF, Xu HHK, Sun L.  Injectable calcium phosphate cement: Effects of powder-to-liquid ratio and needle size.  J Biomed Mater Res Part B 2008;84B:493-502.

Weir MD, Xu HHK.  High-strength, in situ-setting calcium phosphate composite with protein release.  J Biomed Mater Res 2008;85A:388-396.

Xu HHK, Weir MD, Simon CG.  Injectable and strong nano-apatite scaffolds for cell/growth factor delivery and bone regeneration.  Dent Mater (2008, in press).

Moreau JL, Weir MD, Xu HHK.  Self-setting collagen-calcium phosphate bone cement:  Mechanical and cellular properties.  J Biomed Mater Res A (2008, in press).

Xu HHK, Weir MD, Sun L, Ngai S, Takagi S, Chow LC.  Effects of filler level and particle size on caries-inhibiting dental nanocomposite with Ca²⁺ and PO₄ release.  Biomaterials (2008, in review). 

Xu HHK, Sun L, Weir MD, Takagi S, Chow LC, Hockey B.  Effects of nano-sized monocalcium phosphate monohydrate fillers on Ca-and-PO₄-releasing dental composites.  J Biomed Mater Res: Appl Biomater 2007;81B:116-125.

Xu HHK, Weir MD, Sun L, Takagi S, Chow LC.  Effect of calcium phosphate nanoparticles on Ca-PO₄ composites.  J Dent Res 2007;86:378-383.

Xu HHK, Carey LE, Simon CG Jr, Takagi S, Chow LC.  Premixed calcium phosphate cements: synthesis, physical properties, and cell cytotoxicity.  Dental Materials 2007;23:433-441.

Sun L, Xu HHK, Takagi S, Chow LC.  Fast setting CPC-chitosan composite:  Mechanical properties and dissolution rates.  J Biomater Appl  2007;21:299-315.

Xu HHK, Weir MD, Sun L.  Dental nanocomposites with Ca-PO₄ release:  Effects of reinforcement, dicalcium phosphate particle size and silanization.  Dental Materials 2007;23:1482-1491.

Xu HHK, Carey LE, Simon CG.  Macroporous scaffold of premixed calcium phosphate bone cement: Mechanical properties and cell response.  J Mater Sci: Mater in Medicine 2007;18:1345-1353.

Xu HHK, Weir MD, Simon CG.  In situ setting nano-apatite scaffolds: Load-bearing properties and delivery of cells and growth factors.  Acad Dent Mater Trans 2007;21:14-29.

Xu HHK, Carey LE, Burguera EF.  Strong, macroporous, and in situ-setting calcium phosphate cement layered structures.  Biomaterials 2007;28:3786-3796. 

Textbooks and Textbook Chapters

Fouad AF, Huang GT. Inflammation and Host Responses, Chapter 9 in: Ingle’s Endodontics, Bakland L and Baumgartner JC, Editors, 7th Edition, (Becker 2008)

Fouad AF. Molecular Mediators of Pulpal Inflammation, Chapter 11 in: The Dental Pulp, Hargreaves K and Goodis H, Editors, 2^nd Edition, Quintessence Int., (in press).

Taboas JM, Kuo CK, Huang GT, Tuan RS. Chapter 5, Growth Factors in Adult Stem Cell Based Tissue Engineering. In Translational Approaches in Tissue Engineering and Regenerative Medicine; Artech House, Co-Editors: Jeremy Mao, Gordana Vunjak-Novakovic, Antonios Mikos, Anthony Atala. 2007

Li WJ, Gollapudi K, Patterson DP, Huang, GT, Tuan RS.  Chapter: Cell-based therapies for musculoskeletal repair. In Principles of Regenerative Medicine, eds, A. Atala, R. Lanza, J.A. Thomson, R.M. Nerem. 2008.

Fouad AF, Huang GT Chapter 9: Inflammation and Immunological Response. Ingle’s Endodontics – 6th Ed. 2008.

Huang GT, Fouad AF,  Chapter on The Management of Endodontic Infections in Incompletely Developed Teeth, Endodontic Microbiology, In process with the  editor

Sensi, LG, Co-Aurthor, Kina S, Bruguera A. Invisible - Esthetic Ceramic Restorations (in Portuguese). Dental Press, 2007.

Duraes GV, Jham BC, Marson FC, Duarte Jr S, Strassler HE, Sensi LG. Esthetic restoration of dental deformities (in Portuguese). Pró-Odonto Estética, Sescad 2008.

Patents

Three-dimensional periodontal diagnosis software.
Dr Bart Vandenberghe, UMB,  Dr Debora Armellini, Dr Raj Shekhar, UMB, medical school, Diagnostic Radiology UMB Docket N DA-2008-042

Domestic Patent Awarded - US Patent Number 0264291- Compositions and Methods for Preventing or Reducing Plaque and/or Gingivitis Using a Bioactive Glass Containing Dentifrice. Litkowski, LJ, Hack, GD.

Foreign Patent Awarded – Canadian Letters   Patent Number 2,244,722. Bioactive Glass   Compositions and Methods of Treatment Using Bioactive Glass. Litkowski, LJ, Hack GD.

Foreign Patent Awarded – Hong Kong Certificate of Grant of patent Number HK1028959. Methods and Compositions for Whitening Teeth. Litkowski LJ, Hack GD.

Abstracts

Noohi B; Masri, RM; Driscoll, CF; Romberg, E:  Effect of Lubricants on the Retention of Cast Post and Cores. J Den Res 2008; 87:

L. Zhu, M. Tolba, D. Arola, M. Salloum, J. Alvarez, F. Meza, and A. Fouad. Theoretical evaluation of tissue damage using Er,Cr:YSGG Laser for root canal preparation.  Proceedings of ASME 2008 Summer Bioengineering Conference (BIO2008) June 25-29, Marriott Resort, Marco Island, Florida, USA

Fouad AF, Nandakumar R, Paster BJ. Diversity of endodontic microflora in patients with different clinical variables J Dent Res 2008; March Special issue. Abstract #565

P. Chand, R. Nandakumar , Fouad AF. Single vs. Multiple visits: A  molecular analysis of persistent bacteria following single vs. multiple visit preparation. J Endod 2008: 34 (3): 349.

Dalrymple, G.B., Nandakumar, R., Fouad, AF. Identification of antibiotic resistance genes in primary and persistent endodontic infections. J Endod 2008: 34 (3): 350.

Kholodenko, Y., Nandakumar, R., Hnidza, B., Fouad, AF. The effect of endodontic instrumentation techniques on the amount of periapically extruded bacteria. J Endod 2008: 34 (3): 363.

Russo JA, Mirchandani R., Nandakumar R, Fouad AF. Molecular identification of E. faecalis and other bacteria in periapical lesions J Endod 2008: 34 (3): 353.

Nandakumar R, Tofigh M, Paster  BJ, Barbuto S., Fouad AF. Diversity and Sources of Enterococcus Spp in Endodontic Infections. J Dent Res 2008. Special issue. Abstract #751

Fouad AF, Paster BJ, Nandakumar R, Barbuto S. Microbial diversity in primary and therapy-resistant endodontic infections. J Dent Res 2008. Special issue. Abstract #1525

Hack, GD, Chand, PS, Shah, CP, Fouad AF. Early Introduction of Advanced Digital Radiography Utilizing Newly Designed Mobile X-Ray Cabinets. American Dental Education Association Annual Meeting.

Huang GT, SHI S, Djouad F, Tuan RS. Lentiviral Vector-Mediated Transduction of Human Mesenchymal Stem Cells. J. Dent. Res., 2008.

Huang GT, Shi S, Tuan RS.. Characterization of Dental Stem Cells from Pulp and Apical Papilla in vitro. J. Endodont., AAE, 2008.

Huang GT Pulp Stem Cells for Pulp Regeneration. J. Endodont., 07-E-38-AAE, 2007.

Huang GT, Ego-Osuala D, PARK SH, Shea LD, Tuan RS. Pulp Stem Cells Grown in Scaffolds and on Dentin. J. Dent. Res.,  #1447, 2007.(session chair)

Keith A. Mays, Maureen L. Stone. Compensatory Mandibular Movement during Speech in Response to Intra-Oral Perturbation: A Preliminary Evaluation of Vowels and Consonants. AADR 2008 (Abstract 191)

L.G. SENSI, H. STRASSLER. Comparison of cutting efficiency of dentated burs. J Dent Res, March Special Issue, Abstract no. 1021

R. RUSH, J. WHITING, H. STRASSLER, and L.G. SENSI. Color stability of self-etch/self-adhesive resin cements. J Dent Res, Abstract no. 3139

F.C. MARSON, L.G. SENSI, H. STRASSLER, H. RIEHL, R. REIS. In-Office Bleaching Gel Application Times: Clinical Evaluation. J Dent Res, Abstract no. 1027

F.C. MARSON, L.G. SENSI, H. STRASSLER, L. MIRAZIZ, and H. RIEHL. In-Office Bleaching Gel-Application Time Evaluation (3x15min X 1x45min): Pilot studies. J Dent Res, Abstract no. 1027

Strassler HE. Can stimulation be used to teach caries diagnosis, detection and treatment? ADEA meeting, Dallas, Texas, 2008

Moreau JL, Weir MD, Xu HHK.  Mechanical and cellular properties of in situ setting collagen-calcium phosphate bone cement.  Abstract submitted to IADR 2008 meeting in Toronto.

Weir MD, Xu HHK. Characterization of Cell Differentiation on CPC for Bone Tissue Engineering.  Abstract submitted to IADR 2008 meeting in Toronto.