Volumetric changes in the rat brain with pain
|Neural and Pain Sciences|
In this study, we showed that a relative volumetric decrease in PFC was observed at the same time as the onset of anxiety-like behavior (bottom graph) in a rat model (spared nerve injury, SNI) of chronic neurophathic pain.
Seminowicz D.A., Laferriere A.L., Millecamps M., Yu J.S.C., Coderre T.J. and Bushnell M.C. (2009). MRI structural brain changes associated with sensory and emotional function in a rat model of long-term neuropathic pain. Neuroimage, 47: 1007-1014