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Neural  & Pain Sciences

Topic I

Aliquam felis leo, varius in consectetur nec, tincidunt vel magna. Mauris euismod congue nisi, id ullamcorper nisi pretium nec. Cras in tortor sed mi tristique imperdiet. Cras sapien magna, fermentum sed tincidunt et, rutrum eget mauris. Vestibulum vehicula interdum arcu sit amet laoreet. Aliquam nec mi vitae sapien mattis auctor nec quis orci. Phasellus vel est enim, at vulputate nulla. Lorem ipsum dolor sit amet, consectetur adipiscing elit. Sed mattis lobortis nisl, in gravida libero euismod eget. Ut pellentesque massa vel enim tincidunt dapibus. Mauris suscipit orci at neque luctus dignissim.

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Topic II

Aliquam felis leo, varius in consectetur nec, tincidunt vel magna. Mauris euismod congue nisi, id ullamcorper nisi pretium nec. Cras in tortor sed mi tristique imperdiet. Cras sapien magna, fermentum sed tincidunt et, rutrum eget mauris. Vestibulum vehicula interdum arcu sit amet laoreet. Aliquam nec mi vitae sapien mattis auctor nec quis orci. Phasellus vel est enim, at vulputate nulla. Lorem ipsum dolor sit amet, consectetur adipiscing elit. Sed mattis lobortis nisl, in gravida libero euismod eget. Ut pellentesque massa vel enim tincidunt dapibus. Mauris suscipit orci at neque luctus dignissim.

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Topic III

This project will generate modified lipid A structures with altered proimflammatory responses via expression of heterologous lipid A biosynthetic enzymes. Individual lipid A structures will be tested for adjuvant potential in a variety of in vitro and in vivo models.

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Topic IV

Mass spectrometry and gas chromatography-based approaches will be used to establish comprehensive lipidomic databases for Francisella tularensis and Acinetobacter baumannii grown under standard laboratory conditions and those which mimic the bacteria’s natural environment(s) with the potential use to discern between a naturally-occurring microbe and one previously cultured and maliciously dispersed.

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