Ronald Dubner, DDS, PhD
|Neural & Pain Sciences|
Our research program has major funding and collaborations with Drs. Ke Ren and Feng Wei in the school of dentistry and Dr. Asaf Keller in the school of medicine. I am also a principal investigator of the multi-center prospective study funded by the National Institute of Dental and Craniofacial Research on risk determinants of temporomandibular joint and muscle dysfunction (TMD). We have opportunities for postdoctoral fellows and graduate students interested in the study of pain at the basic science and clinical science level. Please contact any of us for further information.
Feng Wei, PhD, MD
Understanding pain mechanism and relieving chronic pain remains a major challenge in biomedicine. Pain is a multidimensional experience attributed to the multiplicity of involved brain sites via distinct anatomical pathways. Our study on experimentally induced pain in animals has shown excitatory synaptic plasticity in the CNS, including spinal dorsal horn, ventral medulla and anterior cingulated cortex. My long goal is directed at understanding the cellular and molecular mechanisms of synaptic plasticity underlying development of persistent pain.
Ke Ren, PhD, MD
We are studying mechanisms that underlie the development and maintenance of persistent pain and hyperalgesia. We employ a wide range of techniques including behavioral pharmacology, focal brain microinjection and stimulation, electrophysiology, immunocytochemistry, in situ hybridization histochemistry, RNA and protein analysis using Western and Northern blots, and RT-PCR. This multidisciplinary approach allows us to address the mechanisms of persistent pain at both systemic and molecular levels.