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Ronald Dubner, PhD, DDS

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Organized Research Center on Persistent Pain | Contact Information |

Neural & Pain Sciences

Dr. Dubner
PUBLICATIONS

  • W. Guo, S-P. Zou, Y. Guan, T. Ikeda, M. Tal, R. Dubner, K. Ren (2002) Tyrosine phosphorylation of the NR2B subunit of the NMDA receptor in the spinal cord during the development and maintenance of inflammatory hyperalgesia. J Neurosci 22: 6208-6217 
  • Guan Y, Terayama R, Dubner R, Ren K (2002) Plasticity in Excitatory Amino Acid Receptor-Mediated Descending Pain Modulation after Inflammation. J Pharmacol Exp Ther 300:513-520 
  • Miki K, Zhou Q, Guo W, Y. Guan, Terayama R, Dubner R, Ren K (2002) Changes in gene expression and neuronal phenotype in brainstem pain modulatory circuitry after inflammation. J Neurophysiol 87:750-760
  • Ren K, Dubner R (2002) Descending modulation in persistent pain: an update. Pain 100:1-6 
  • Guo W, Wei F, Zou S-P, Sugiyo S, Ikeda T, Meredith T. Robbins, Tu J-C, Worley PF, Dubner R, Ren K (2004) Group I metabotropic glutamate receptor-NMDA receptor coupling and signaling cascade mediate spinal dorsal horn NR2B tyrosine phosphorylation associated with inflammatory hyperalgesia. J Neurosci 24: 9161-9173. 
  • Sugiyo S, Takemura M, Dubner R, Ren K (2005) Trigeminal transition zone/rostral ventromedial medulla connections and facilitation of orofacial hyperalgesia after masseter inflammation in rats. J. Comp. Neurol. 493:510-523. 
  • Guo W, Robbins MT, Wei F, Zou S, Dubner R, Ren K (2006) Supraspinal brain-derived neurotrophic factor signaling: a novel mechanism for descending pain facilitation. J. Neuroscience 26:126-137
  • Anseloni, V.C.Z., Weng, H-R, Terayama, R., Letizia, D., Davis, B.J., Ren, K., Dubner, R., and Ennis, M. Age-dependency of analgesia elicited by intraoral sucrose in acute and perisistent pain models. Pain 97: 93-103, 2002.
  • Ren, K. and Dubner, R., Descending modulation in persistent pain: an update. Pain 100:1-6, 2002.  
  • Gordon SM, Brahim JS, Dubner R, McCullagh LM, Sang CN, Dionne RA. Attenuation of pain in a randomized trial by suppression of peripheral nociceptive activity in the immediate postoperative period. Anesth Analg 95: 1351-7, 2002.
  • Guan, Y., Guo.W., Zou S.-P., Dubner, R. and Ren, K. Inflammation-induced upregulation of AMPA receptor subunit expression in brain stem pain modulatory circuitry. Pain104: 401-413, 2003.
  • Ikeda, T., Terayama,R., Jue, S-S., Sugiyo, S., Dubner, R. and Ren, K. Differential rostral projections of caudal brain stem neurons receiving trigeminal input after masseter inflammation. J. Comp. Neurol. 465: 220-233, 2003.
  • Dubner, R., Greenspan, J.D. and Gold, M.S. Beyond poppy juice: the new science of pain. Cerebrum 5:65-79, 2003.
  • Price, D.D., Greenspan, J.D. and Dubner, R. Neurons involved in the exteroreceptive function of pain. Pain 106:215-219, 2003.  
  • Vanessa Anseloni, Ke Ren, Ronald Dubner, Matthew Ennis (2004) Ontogeny of analgesia elicited by non-nutritive suckling in acute and persistent neonatal rat pain models. Pain 109:507-13.
  • Ke Ren, Vanessa Anseloni, Shipping Zhou, Eleanor Wade, Svetlana Novikova, Matthew Ennis, Richard Traub, Michael Gold, Ronald Dubner, Michael Lidow (2004) Characterization of basal and re-inflammation-associated long-term alteration in pain responsivity Pain 110:588-596.
  • Dubner R, Ren K (2004) Brain stem mechanisms of persistent pain following injury. J Orofacial Pain 18:299-305.
  • Dubner R and Ren K (2004) Brainstem modulation of pain after inflammation. In: Progress in Pain Research and Management, edited by L. Villanueva, A Dickenson, H Ollat, IASP Press, Seattle, p.107-120.
  • Ren K, Novikova S, He F, Dubner R, Lidow, M (2005) Neonatal local noxious insult affects gene expression in the spinal dorsal horn of adult rats. Molecular Pain 1:27.
  • Sugiyo S, Takemura M, Dubner R, Ren K (2005) Trigeminal transition zone/rostral ventromedial medulla connections and facilitation of orofacial hyperalgesia after masseter inflammation in rats. J. Comp. Neurol. 493:510-523.
  • Bond, M.R., Dubner, R., Jones, L.E. and Meldrum M.L.  (2005) The history of the IASP: progress in pain since 1975. In: Merskey, H., Loeser, J.D. and Dubner, R. (eds.) The Paths of Pain 1975-2006, IASP Press, Seattle, p.23-32.
  • Guo W, Zou S-P, Ikeda T, Dubner R, Ren K. 2005 Rapid and lasting increase in serine phosphorylation of rat spinal cord NMDAR1 and GluR1 subunits after peripheral inflammation. Thalamus & Related Systems 3:9-18.
  • Wang H, Wei F, Dubner R, Ren K. 2006 Selective distribution and function of primary afferent nociceptive inputs from deep muscle tissue to the brainstem trigeminal transition zone. J Comp Neurol 498:390-402.
  • Sugiyo S, Takemura M, Dubner R, Ren K. 2006 Demonstration of a trigeminothalamic pathway to the oval paracentral intralaminar thalamic nucleus and its involvement in the processing of noxious orofacial deep inputs. Brain Res 1097:116-122.
  • Dubner, R. (2005) Plasticity in central nociceptive pathways. In: Merskey, H., Loeser, J.D. and Dubner, R. (eds.) The Paths of Pain 1975-2006, IASP Press, Seattle, p.101-116.
  • Dubner, R. (2006) Descending modulatory ciruitry in the initiation and maintenance of neuropathic pain. In: Campbell, J. N., Basbaum, A. I., Dray, A, Dubner, R., Dworkin, R. H., Sang, Christine, C. N. (eds) Emerging Strategies for the Treatment of Neuropathic Pain, IASP Press, Seattle, p. 123-138.
  • Dubner R, Ren K. 2006 Persistent Orofacial Pain.  In:  Temporomandibular Disorders: An Evidence-Based Approach to Diagnosis and Treatment. Eds. Laskin DM, Greene CS, Hylander WL, Quintessence Publishing Co, Inc, Chicago, pp. 89-97
  • Guo W, Robbins MT, Wei F, Zou S, Dubner R, Ren K (2006) Supraspinal brain-derived neurotrophic factor signaling: a novel mechanism for descending pain facilitation. J. Neuroscience 26:126-137. 
  • Ren K, Dubner R. 2007 Pain Facilitation and Activity-Dependent Plasticity in Pain Modulatory Circuitry: Role of BDNF-TrkB Signaling and NMDA Receptors. Mol Neurobiol 35:224-35.
  • Guo W, Dubner R, Ren K. 2006 Spinal N-methyl-D-aspartate receptor mechanisms of central sensitization and persistent pain following tissue injury. In: Translational Pain Research, Mao JR, ed. Nova Science Publishers, Inc: New York. pp.45-78.
  • Ren K, Dubner R. 2008 Descending control mechanisms.  In: Basbaum AI, Kaneko A, Shepherd GM, Westheimer G, editors, The Senses:  A Comprehensive Reference, Volume 5: Pain, Eds. Bushnell MC, Basbaum AI, Academic Press, San Diego, pp. 723-762.
  • Ren K, Dubner R. 2008 Neural-glia crosstalk gets serious:  Role in pain hypersensitivity Curr Opi Anesthesiol 21: 570-579.
  • Wei F, Guo W, Zou S, Ren K, Dubner R. 2008 Supraspinal glial activation and cytokine induction contribute to descending facilitation. J. Neurosci. 28: 10482-10495. PMC2660868
  • McNeill C, Dubner R, Woda, A. 2008 What is pain and how do we classify orofacial pain? In: Sessle, B.J., , Lavigne, G.J., Lund, J.P. and Dubner, R.. (eds.) Orofacial Pain, From Basic Science to Clinical Management. Quintessence, 2nd Edition, p.3-11.
  • Sessle  BJ, Iwata K, Dubner R. 2008 Central nociceptive pathways. In: Sessle, B.J., , Lavigne, G.J., Lund, J.P. and Dubner, R.. (eds.) Orofacial Pain, From Basic Science to Clinical Management. Quintessence, 2nd Edition, p. 35-43.
  • Dubner R, Iwata K, Murray GM, Avivi-Arber L, Svensson P, Cairns BE, Lavigne GJ. 2008. From pain to movement: a tribute to professor Barry J. Sessle. J. Orofac. Pain 22: 287-96.
  • Dubner R. 2009. A bibliometric analysis of the Pain journal as a representation of progress and trends in the field. Pain 142: 9-10.
  • Ren K, Dubner R. 2009  Glutamate and GABA receptors in pain transmission. In: Beaulieu P, Lussier D, Poreca F, Dickenson AH (editors), Pharmacology of Pain, IASP Press, Seattle, in press.
  • K. Shimizu, Bryan Chai, Stacey C. LaGraize, F. Wei, R. Dubner, K. Ren . 2009 Microinjection of IL-1β into the trigeminal transition zone produces bilateral NMDA receptor-dependent orofacial hyperalgesia involving descending circuitry. The Open Pain Journal, 2:76-83.NIHMSID #158803.
  • Berman BM, Langevin HH, Witt CM, Dubner R. 2010 Acupuncture for chronic low back pain. N. Engl. J. Med. 363:454-461. PMCID: PMC-In Process.
  • LaGraize SC, Guo W, Yang K, Wei F, Ren K, Dubner. 2010 Spinal cord mechanisms mediating behavioral hyperalgesia induced by neurokinin-1 tachykinin receptor activation in the rostral ventromedial medulla. Neuroscience 171:1341-56. PMCID: PMC 3006078
  • Wang H, Guo W, Yang K, Wei F, Dubner R, Ren K. 2010 Contribution of Primary Afferent Input to Trigeminal Astroglial Hyperactivity, Cytokine Induction and NMDA Receptor Phosphorylation. Open Pain J. 3:144-152. PMCID: PMC3002905

  • Guo W, Wang H, Zou S, Gu M, Watanabe M, Wei F, Dubner R, Huang GT, Ren K.  2011 Bone marrow stromal cells produce long-term pain relief in rat models of persistent pain.  Stem Cells. 29(8):1294-303. PMCID:PMC3277433