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Huakun (Hockin) Xu, PhD, MS
Professor, Director of Dental Biomaterials Courses
Biomaterials and Tissue Engineering

Publications:

2013

  • Song G, Habibovic P, Bao C, Hu J, van Blitterswijk CA, Yuan H, Chen W, Xu HHK. Bone marrow mesenchymal stem cells home to non-osseous site for ectopic bone formation induced by osteoinductive calcium phosphate in canine model. Biomaterials 2013;34:2167-2176. NIHMSID #: 432977.
  • Liu J, Xu HHK, Zhou H, Weir MD, Chen Q, Trotman CA. Human umbilical cord stem cell encapsulation in novel macroporous and injectable fibrin for muscle tissue engineering. Acta Biomaterialia 2013;9:4688-4697. NIHMSID #: 424492. PubMed #: 22902812. PMC #: 3535490.
  • Cheng L, Weir MD, Zhang K, Arola DD, Zhou X, Xu HHK. Dental primer and adhesive containing a new antibacterial quaternary ammonium monomer dimethylaminododecyl methacrylate. J Dent (2013, accepted for publication). NIHMSID #: 437056.
  • Zhang K, Li F, Imazato S, Cheng L, Liu H, Arola DD, Bai Y, Xu HHK. Dual antibacterial agents of nano-silver and 12-methacryloyloxydodecylpyridinium bromide in dental adhesive to inhibit caries. J Biomed Mater Res B (2013, accepted for publication). NIHMSID #: 437062.
  • Melo MAS, Cheng L, Weir MD, Hsia RC, Rodrigues LKA, Xu HHK. Novel dental adhesive containing antibacterial agents and calcium phosphate nanoparticles. J Biomed Mater Res B (2013, accepted for publication). PubMed #: 23281264. NIHMSID #: 432560.
  • Chen W, Zhou H, Weir MD, Tang M, Bao C, Xu HHK. Human embryonic stem cell seeding on calcium phosphate cement-RGD scaffold for bone repair. Tissue Engineering A (2013, accepted for publication) doi:10.1089/ten.TEA.2012.0172. PubMed #: 23092172. NIHMSID #: 424490.
  • Melo MAS, Cheng L, Zhang K, Weir MD, Rodrigues LKA, Xu HHK. Novel dental adhesives containing nanoparticles of silver and amorphous calcium phosphate. Dent Mater (2013, accepted for publication) doi:10.1016/j.dental.2012.10.005. PubMed #: 23138046. NIHMSID #: 419967.
  • Melo MAS, Weir MD, Rodrigues LKA, Xu HHK. Novel calcium phosphate nanocomposite with caries-inhibition in a human in situ model. Dent Mater (2013, accepted for publication) doi:10.1016/j.dental.2012.10.010. NIHMSID #: 421489.
  • Thein-Han WW, Weir MD, Simon CG, Xu HHK. Non-rigid and tough calcium phosphate cement scaffold seeded with umbilical cord stem cells for bone repair. Journal of Tissue Engineering and Regenerative Medicine (2013, accepted for publication) doi:10.1002/term.1466. NIHMSID #: 424493.

2012

  • Liu J, Zhou H, Weir MD, Xu HHK, Chen Q, Trotman CA. Fast-degradable microbeads encapsulating human umbilical cord stem cells in alginate for muscle tissue engineering. Tissue Eng A 2012;18:2303-14. NIHMSID #: 424486. PubMed #: 22697426. PMC #: 3482877.
  • Zhou H, Chen WC, Weir MD, Xu HHK. Biofunctionalized calcium phosphate cement to enhance the attachment and osteodifferentiation of stem cells released from fast-degradable alginate-fibrin microbeads. Tissue Eng Part A 2012;18:1583-95. NIHMSID #: 424489. PubMed #: 22435653. PMC #: 3419861.
  • Weir MD, Chow LC, Xu HHK. Remineralization of demineralized enamel via calcium phosphate nanocomposite. J Dent Res 2012;91:979-984. NIHMSID #: 432558. PubMed #: 22933607. PMC #: 3446834.
  • Thein-Han W, Xu HHK. Calcium phosphate cement with biofunctional agents and stem cell seeding for dental and craniofacial bone repair. Dent Mater 2012;28:1059-1070. NIHMSID #: 395200. PubMed #: 22809583. PMC #: 3535491.
  • Cheng L, Weir MD, Xu HHK, Antonucci JM, Lin NJ, Lin-Gibson S, Xu SM, Zhou XD. Effect of amorphous calcium phosphate and silver nanocomposites on dental plaque microcosm biofilms. J Biomed Mater Res B 2012;100:1378-1386. NIHMSID #: 380809. PubMed #: 22566464. PMC #: 3373271.
  • Moreau JL, Weir MD, Giuseppetti AA, Chow LC, Antonucci JM, Xu HHK. Long-term mechanical durability of dental nanocomposites containing amorphous calcium phosphate nanoparticles. J Biomed Mater Res B 2012:100;1264-1273. NIHMSID #: 380808. PubMed #: 22514160. PMC #: 3373274.
  • Chen W, Zhou H, Tang M, Weir MD, Bao C, Xu HHK. Gas-foaming calcium phosphate cement scaffold encapsulating human umbilical cord stem cells. Tissue Engineering A 2012;18:816-827. PubMed #: 22011243. NIHMSID #: 338727.
  • Cheng L, Weir MD, Zhang K, Wu E, Xu SM, Zhou XD, Xu HHK. Dental plaque microcosm biofilm behavior on calcium phosphate nanocomposite with quaternary ammonium. Dent Mater 2012;28:853-862. NIHMSID #: 372497. PubMed #: 22578992. PMC #: 3393817.
  • Zhang K, Melo MAS, Cheng L, Weir MD, Bai YX, Xu HHK. Effect of quaternary ammonium and silver nanoparticle-containing adhesives on dentin bond strength and dental plaque microcosm biofilms. Dent Mater 2012;28:842-852. NIHMSID #: 372498. PubMed #: 22592165. PMC #: 3393841.
  • Tang M, Chen W, Weir MD, Thein-Han W, Xu HHK. Human embryonic stem cell-encapsulation in alginate microbeads in macroporous calcium phosphate cement for bone tissue engineering. Acta Biomaterialia 2012;8:3436-3445. NIHMSID #: 379290. PubMed #: 22633970. PMC #: 3408764.
  • Cheng L, Zhang K, Melo MAS, Weir MD, Zhou XD, Xu HHK. Anti-biofilm dentin primer with quaternary ammonium and silver nanoparticles. J Dent Res 2012;91:598-604. NIHMSID #: 380811. PubMed #: 22492276.
  • Cheng L, Weir MD, Zhang K, Xu SM, Q Chen, Zhou XD, Xu HHK. Antibacterial nanocomposite with calcium phosphate and quaternary ammonium. J Dent Res 2012;91:460-466. NIHMSID #: 380810. PubMed #: 22403412. PMC #: 3327730.
  • Chen W, Zhou H, Weir MD, Bao C, Xu HHK. Umbilical cord stem cells released from alginate-fibrin microbeads inside macroporous and biofunctionalized calcium phosphate cement for bone regeneration. Acta Biomaterialia 2012;8:2297-2306. NIHMSID #: 365653. PubMed #: 22391411. PMC #: 3360975.
  • Weir MD, Moreau JL, Levine ED, Strassler HD, Chow LC, Xu HHK. Nanocomposite containing CaF2 nanoparticles: Thermal cycling, wear and long-term water-aging. Dental Materials 2012;28:642–652. NIHMSID #: 360845. PubMed #: 22429937. PMC #: 3360976.
  • Cheng L, Weir MD, Limkangwalmongkol P, Hack GD, Xu HHK, Chen QM, Zhou XD. Tetracalcium phosphate composite containing quaternary ammonium dimethacrylate with antibacterial properties. J Biomed Mater Res B 2012;100:726-734. NIHMSID #: 380807. PubMed #: 22190356. PMC #: 3373275.
  • Cheng L, Weir MD, Xu HHK, Antonucci JM, Kraigsley AM, Lin NJ, Lin-Gibson S, Zhou XD. Antibacterial amorphous calcium phosphate nanocomposite with quaternary ammonium salt and silver nanoparticles. Dent Mater 2012;28:561-572. NIHMSID #: 350779. PubMed #: 22305716. PMC #: 3322309.
  • Cheng L, Weir MD, Xu HHK, Kraigsley AM, Lin NJ, Lin-Gibson S, Zhou X. Antibacterial and physical properties of calcium-phosphate and calcium-fluoride nanocomposites with chlorhexidine. Dent Mater 2012;28:573-583. NIHMSID #: 350780. PubMed #: 22317794. PMC #: 3322264.
  • Tang M, Weir MD, Xu HHK. Mannitol-containing macroporous calcium phosphate cement encapsulating human umbilical cord stem cells. Journal of Tissue Engineering and Regenerative Medicine 2012;6:214-224. NIHMSID #: 287815. PubMed #: 21442765. PMC #: 3144283.
  • Xu HHK, Weir MD, Zhao L, Moreau JL, Arola DD, Simon CG. Nano-apatitic composite scaffolds for stem cell delivery and bone tissue engineering. Chapter 12 in Emerging Nanotechnologies in Dentistry-Materials, Processes, and Applications. Edited by Subramani K and Ahmed W. William Andrew (an Imprint of Elsevier), New York, pp. 189-207, 2012.

2011

  • Thein-Han WW, Xu HHK. Collagen-calcium phosphate cement scaffolds seeded with umbilical cord stem cells for bone tissue engineering. Tissue Eng A 2011;17:2943-2954. NIHMSID #: 331813. PubMed #: 21851269. PMC #: 3226062.
  • Zhou H, Weir MD, Xu HHK. Effect of cell seeding density on proliferation and osteodifferentiation of umbilical cord stem cells on calcium phosphate cement-fiber scaffold. Tissue Eng Part A 2011;17: 2603-2613. NIHMSID #: 331816. PubMed #: 21745111. PMC #: 3204200.
  • Bao C, Chen W, Weir MD, Thein-Han W, Xu HHK. Effects of electrospun submicron fibers in calcium phosphate cement scaffold on mechanical properties and osteogenic differentiation of umbilical cord stem cells. Acta Biomaterialia 2011;7:4037-4044. NIHMSID #: 314017. PubMed #: 21763791. PMC #: 3185192.
  • Moreau JL, Sun L, Chow LC, Xu HHK. Mechanical and acid neutralizing properties and inhibition of bacterial growth of amorphous calcium phosphate dental nanocomposite. J Biomed Mater Res Part B 2011;98:80-88. NIHMSID #: 380806. PubMed #: 21504057. PMC #: 3375606.
  • Zhou H, Xu HHK. The fast release of stem cells from alginate-fibrin microbeads in injectable scaffolds for bone tissue engineering. Biomaterials 2011;32:7503-7513. NIHMSID #: 308519. PubMed #: 21757229. PMC #: 3159408.
  • Zhao L, Tang M, Weir MD, Detamore MS, Xu HHK. Osteogenic media and rhBMP-2 induced differentiation of umbilical cord mesenchymal stem cells encapsulated in alginate microbeads and integrated in an injectable calcium phosphate-chitosan fibrous scaffold. Tissue Engineering Part A 2011;17:969-979. NIHMSID #: 331812. PubMed #: 21091340. PMC #: 3063701.
  • Xu HHK, Moreau JL, Sun L, Chow LC. Nanocomposite containing amorphous calcium phosphate nanoparticles for caries inhibition. Dent Mater 2011;27:762-769. NIHMSID #: 291163. PubMed #: 21514655. PMC #: 3125490.

2010

  • Xu HHK, Zhao L, Weir MD. Stem cell-calcium phosphate constructs for bone engineering. J Dent Res 2010;89:1482-1488.
  • Moreau JL, Xu HHK. Fluoride releasing restorative materials: Effects of pH on mechanical properties and ion release. Dent Mater 2010;26:e227-e235.
  • Xu HHK, Zhao L, Detamore MS, Takagi S, Chow LC. Umbilical cord stem cell seeding on fast-resorbable calcium phosphate bone cement. Tissue Engineering Part A 2010;16:2743-2753.
  • Weir MD, Xu HHK. Human bone marrow stem cell-encapsulating calcium phosphate scaffolds for bone repair. Acta Biomaterialia 2010;6:4118-4126.
  • Zhao L, Weir MD, Xu HHK. An injectable calcium phosphate - alginate hydrogel - umbilical cord mesenchymal stem cell paste for bone tissue engineering. Biomaterials 2010;31:6502-6510.
  • Xu HHK, Moreau JL, Sun L, Chow LC. Novel CaF2 nanocomposite with high strength and F ion release. J Dent Res 2010;89:739-745.
  • Weir MD, Xu HHK. Osteoblastic induction on calcium phosphate cement-chitosan constructs for bone tissue. J Biomed Mater Res A 2010;94A:223–233.
  • Xu HHK, Moreau JL. Dental glass-reinforced composite with calcium and phosphate ion release for caries inhibition. J Biomed Mater Res 2010;92B:332–340.
  • Zhao L, Weir MD, Xu HHK. Human umbilical cord stem cell encapsulation in calcium phosphate scaffolds for bone engineering. Biomaterials 2010;31:3848–3857.
  • Xu HHK, Weir MD, Sun S, Moreau JL, Takagi S, Chow LC, Antonucci JM. Strong nanocomposites with Ca, PO4 and F release for caries inhibition. J Dent Res 2010;89:19-28.
  • Weir MD, Xu HHK. Culture human mesenchymal stem cells with calcium phosphate cement scaffolds for bone repair. J Biomed Mater Res 2010;93B: 93–105.
  • Zhao L, Burguera EF, Xu HHK, Amin N, Ryou H, Arola DD. Fatigue and human umbilical cord stem cell seeding characteristics of calcium phosphate–chitosan–biodegradable fiber scaffolds. Biomaterials 2010;31:840–847.

2009

  • Moreau JL, Xu HHK. Mesenchymal stem cell proliferation and differentiation on an injectable calcium phosphate-chitosan composite scaffold. Biomaterials 2009;30:2675-2682.
  • Xu HHK, Weir MD, Sun L. Calcium and phosphate ion releasing composite: Effect of pH on release and mechanical properties. Dent Mater 2009;25:535-542.
  • Moreau JL, Weir MD, Xu HHK. Self-setting collagen-calcium phosphate bone cement: Mechanical and cellular properties. J Biomed Mater Res A 2009;91:605-613.
  • Xu HHK, Weir MD, Sun L, Ngai S, Takagi S, Chow LC. Effect of filler level and particle size on dental caries-inhibiting Ca-PO4 composite. J Mater Science: Mater in Medicine 2009;20:1771-1779.

2008

  • Xu HHK, Moreau JL, Sun L, Chow LC. Strength and fluoride release characteristics of a calcium fluoride based dental nanocomposite. Biomaterials 2008;29:4261-4267.
  • Xu HHK, Weir MD, Simon CG. Injectable and strong nano-apatite scaffolds for cell/growth factor delivery and bone regeneration. Dental Materials 2008;24:1212-1222.
  • Weir MD, Xu HHK. High-strength, in situ-setting calcium phosphate composite with protein release. J Biomed Mater Res 2008;85A:388-396.
  • Burguera EF, Xu HHK, Sun L. Injectable calcium phosphate cement: Effects of powder-to-liquid ratio and needle size. J Biomed Mater Res 2008;84B:493-502.

2007

  • Xu HHK, Carey LE, Burguera EF. Strong, macroporous, and in situ-setting calcium phosphate cement layered structures. Biomaterials 2007;28:3786-3796.
  • Xu HHK, Weir MD, Sun L, Takagi S, Chow LC. Effect of calcium phosphate nanoparticles on Ca-PO4 composites. J Dent Res 2007;86:378-383.
  • Xu HHK, Carey LE, Simon CG. Macroporous scaffold of premixed calcium phosphate bone cement: Mechanical properties and cell response. J Mater Science: Mater in Medicine 2007;18:1345-1353.
  • Xu HHK, Sun L, Weir MD, Takagi S, Chow LC, Hockey B. Effects of nano-sized monocalcium phosphate monohydrate on Ca-and-PO4-releasing dental composites. J Biomed Mater Res 2007;81B:116-125.
  • Xu HHK, Carey LE, Simon CG Jr, Takagi S, Chow LC. Premixed calcium phosphate cements: synthesis, physical properties, and cell cytotoxicity. Dental Materials 2007;23:433-441.
  • Sun L, Xu HHK, Takagi S, Chow LC. Fast setting CPC-chitosan composite: Mechanical properties and dissolution rates. J Biomater Appl 2007;21:299-315.
  • Xu HHK, Weir MD, Sun L. Dental nanocomposites with Ca-PO4 release: Effects of reinforcement, dicalcium phosphate particle size and silanization. Dental Materials 2007:23:1482-1491.

2006

  • Xu HHK, Weir MD, Burguera EF, Fraser AM. Injectable and macroporous calcium phosphate cement scaffold. Biomaterials 2006;27:4279-4287.
  • Xu HHK, Sun L, Weir MD, Antonucci J, Takagi S, Chow LC. Nano DCPA-whisker composites with high strength and Ca-PO4 release. J Dent Res 2006;85:722-27.
  • Xu HHK, Takagi S, Sun L, Hussain L, Chow LC, Guthrie WF, Yen JH. Calcium phosphate cement with non-rigidity and strength durability for periodontal bone repair. J American Dent Assoc 2006;137:1131-1138.
  • Burguera EF, Xu HHK, Weir MD. Injectable and rapid-setting calcium phosphate bone cement with dicalcium phosphate dihydrate. J Biomed Mater Res 2006;77B:126-134.
  • Weir MD, Xu HHK, Simon CG. Strong calcium phosphate cement-chitosan-mesh construct containing cell-encapsulating hydrogel beads for bone tissue engineering. J Biomed Mater Res 2006;77A:487-496.
  • Zhang Y, Xu HHK, Takagi S, Chow LC. In-situ hardening hydroxyapatite-based scaffold for bone repair. J Mater Science: Mater in Medicine 2006;17:437-445.

2005

  • Xu HHK, Simon CG Jr. Fast setting calcium phosphate-chitosan scaffold: mechanical properties and biocompatibility. Biomaterials 2005;26:1337-1348.
  • Carey LE, Xu HHK, Simon CG, Takagi S, Chow LC. Premixed rapid-setting calcium phosphate composites for bone repair. Biomaterials 2005;26:5002-5014.
  • Xu HHK, Simon CG Jr, Takagi S, Chow LC, Eichmiller FC. Strong, macroporous and in-situ hardening hydroxyapatite for bone tissue engineering. Biomaterials Forum 2005;27:14-19.
  • Burguera EF, Xu HHK, Takagi S, Chow LC. High early-strength calcium phosphate bone cement: Effects of dicalcium phosphate dehydrate and absorbable fibers. J Biomed Mater Res 2005;75A:966-975.
  • Antonucci JM, Dickens SH, Fowler BO, Xu HHK, McNonough WG. Chemistry of silanes: Interfaces in dental polymers and composites. J Res NIST 2005;110:541-558.
  • Zhang Y, Xu HHK. Effects of synergistic reinforcement and absorbable fiber strength on hydroxyapatite bone cement. J Biomed Mater Res 2005;75A:832-840.

2004

  • Xu HHK, Quinn JB, Takagi S, Chow LC. Synergistic reinforcement of in situ hardening calcium phosphate composite scaffold for bone tissue engineering. Biomaterials 2004;25:1029-1037.
  • Xu HHK, Smith DT, Simon CG. Strong and bioactive composites containing nano-silica-fused whiskers for bone repair. Biomaterials 2004;25:4615-4626.
  • Xu HHK, Quinn JB, Giuseppetti AA. Wear and mechanical properties of nano-silica-fused whisker composites. Journal of Dental Research 2004;83:930-935.
  • Xu HHK, Quinn JB, Giuseppetti AA, Eichmiller FC, Parry EE, Schumacher GE. Three-body wear of dental resin composites reinforced with silica-fused whiskers. Dental Materials 2004;20:220-227.
  • Xu HHK, Simon CG. Self-hardening calcium phosphate cement-mesh composite: Reinforcement, macropores, and cell response. J Biomed Mater Res 2004;69A:267-278.
  • Xu HHK, Takagi S, Quinn JB, Chow LC. Fast-setting and anti-washout calcium phosphate scaffolds with high strength and controlled macropore formation rates. J Biomed Mater Res 2004;68A:725-734.
  • Xu HHK, Simon CG. Self-hardening calcium phosphate composite scaffold for bone tissue engineering. Journal of Orthopaedic Research 2004;22:535-543.

2003

  • Xu HHK. Long-term water aging of whisker-reinforced polymer-matrix composites. Journal of Dental Research 2003;82:48-52.
  • Xu HHK, Quinn JB, Smith DT, Giuseppetti AA, Eichmiller FC. Effects of different whiskers on the reinforcement of dental composites. Dent Mater 2003;19:359-367.
  • Xu HHK, Schumacher GE, Eichmiller FC, Peterson RC, Antonucci JM, Mueller HJ. Continuous-fiber preform reinforcement of dental resin composite restorations. Dental Materials 2003;19:523-530.

2002

  • Xu HHK, Quinn JB, Takagi S, Chow LC . Processing and properties of strong and non-rigid calcium phosphate cement. Journal of Dental Research 2002;81:219-224.
  • Xu HHK, Quinn JB. Calcium phosphate cement containing resorbable fibers for short-term reinforcement and macroporosity. Biomaterials 2002;23:193-202.
  • Xu HHK, Eichmiller FC, Smith DT, Schumacher GE, Giuseppetti AA, Antonucci JM. Effect of thermal cycling on whisker-reinforced dental resin composites. J Mater Sci: Mater in Medicine 2002;13:875-883.
  • Xu HHK, Quinn JB, Smith DT, Antonucci JM, Schumacher GE, Eichmiller FC. Dental resin composites containing silica-fused whiskers – Effects of whisker-to-silica ratio on fracture toughness and indentation properties. Biomaterials 2002;23:735-742.

2001

  • Xu HHK, Quinn JB. Effect of silicon carbide whisker-silica heat treatment on the reinforcement of dental resin composites. J Biomed Mater Res 2001;58B:81-87.
  • Xu HHK, Eichmiller FC, Barndt PR. Effects of fiber length and volume fraction on the reinforcement of calcium phosphate cement. J Mater Science: Mater Med 2001;12:57-65.
  • Xu HHK, Quinn JB. Whisker-reinforced bioactive composites containing calcium phosphate cement fillers: Effects of filler ratio and surface treatments on mechanical properties. J Biomed Mater Res 2001;57A:165-174.
  • Xu HHK, Quinn JB, Takagi S, Chow LC, Eichmiller FC. Strong and macroporous calcium phosphate cement: Effects of porosity and fiber reinforcement. J Biomed Mater Res 2001;57A:457-466.

2000

  • Xu HHK. Whisker-reinforced heat-cured dental resin composites: Effects of filler level and heat-cure temperature and time. J Dent Res 2000;79:1392-1397.
  • Xu HHK, Eichmiller FC, Antonucci JM, Schumacher GE, Ives LK. Dental resin composites containing ceramic whiskers and precured glass ionomer particles. Dent Mater 2000;16:356-363.
  • Xu HHK, Schumacher GE, Eichmiller FC, and Antonucci JM. Strengthening composite resin restorations with ceramic whisker reinforcement. Pract Periodont Aesthet Dent 2000;12:111-116.
  • Xu HHK, Eichmiller FC, Antonucci JM, Flaim GM. Single-crystalline ceramic whisker-reinforced carboxylic acid-resin composites with fluoride release. Operative Dentistry 2000;25:90-97.
  • Xu HHK, Smith DT, Schumacher GE, Eichmiller FC, Antonucci JM. Indentation modulus and hardness of whisker-reinforced heat-cured dental resin composites. Dent Mater 2000;16:248-254.
  • Xu HHK, Eichmiller FC, Giuseppetti AA. Reinforcement of a self-setting calcium phosphate cement with different fibers. J Biomed Mater Res 2000;52:107-114.
  • Xu HHK, Smith DT, Schumacher GE, Eichmiller FC. Whisker-reinforced dental core buildup composites: Effect of filler level on mechanical properties. J Biomed Mater Res 2000;52:812-818.
  • Xu HHK, Quinn JB, Giuseppetti AA, Eichmiller FC. Effects of whisker-to-silica ratio on the reinforcement of dental resin composites with silica-fused whiskers. J Dent Res 2000;79:1844-1849.

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